A clerodane diterpene inhibit adipogenesis by cell cycle arrest and ameliorate obesity in C57BL/6 mice

Molecular and Cellular Endocrinology

Volumn 399, Issue , 2015, Pages 373-385

  Beg, Muheeb ^a   Shankar, Kripa ^a   Varshney, Salil ^a   Rajan, Sujith ^a,b   Singh, Suriya Pratap ^a   Jagdale, Pankaj ^c   Puri, Anju ^a   Chaudhari, Bhushan P ^c   Sashidhara, Koneni V ^a   Gaikwad, Anil Nilkanth ^a,b  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH ACSIR   (India)

^c CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

Author keywords

3T3 L1 adipocyte; Clerodane diterpene; Obesity; Orlistat; Statins

Indexed keywords

16ALPHA HYDROXYCLERODA 3, 13 DIEN 15, 16 OLIDE; ADIPONECTIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; CELL CYCLE PROTEIN; CHOLESTEROL; CLERODANE DERIVATIVE; GLUCOSE TRANSPORTER 4; LEPTIN; MAMMALIAN TARGET OF RAPAMYCIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE B; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; CCAAT ENHANCER BINDING PROTEIN; CEBPA PROTEIN, MOUSE; SLC2A4 PROTEIN, MOUSE;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ARTICLE; CELL CYCLE ARREST; CELL DIFFERENTIATION; CELL EXPANSION; CONTROLLED STUDY; CYTOTOXICITY; EPIDIDYMIS FAT; GLUCOSE TOLERANCE; HUMAN; HUMAN CELL; IMPAIRED GLUCOSE TOLERANCE; IN VITRO STUDY; IN VIVO STUDY; LIPID DIET; LIPID STORAGE; LIVER CELL; MALE; MESENCHYMAL STEM CELL; MESENCHYME CELL; MOUSE; NONHUMAN; OBESITY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN; ANIMAL; CELL CYCLE CHECKPOINT; CELL LINE; CHEMISTRY; DRUG EFFECTS; ISOLATION AND PURIFICATION; MESENCHYMAL STROMA CELL; METABOLISM; PATHOLOGY;

ADIPOGENESIS; ANIMALS; CCAAT-ENHANCER-BINDING PROTEINS; CELL CYCLE CHECKPOINTS; CELL LINE; DITERPENES, CLERODANE; GLUCOSE TRANSPORTER TYPE 4; HUMANS; MESENCHYMAL STROMAL CELLS; MICE; OBESITY; PPAR GAMMA;

EID: 84912035810     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2014.09.024     Document Type: Article

References (59)

1. Ahn J., Lee H., Kim S., Ha T. Curcumin-induced suppression of adipogenic differentiation is accompanied by activation of Wnt/beta-catenin signaling. Am. J. Physiol. Cell Physiol 2010, 298:C1510-C1516.
2. Beg M., Chauhan P., Varshney S., Shankar K., Rajan S., Saini D., et al. A withanolide coagulin-L inhibits adipogenesis modulating Wnt/beta-catenin pathway and cell cycle in mitotic clonal expansion. Phytomedicine 2013, 10.1016/j.phymed.2013.10.009.
3. Bhatta R.S., Kumar D., Chhonker Y.S., Singh S.P., Sashidhara K.V., Jain G.K. Simultaneous estimation of 16alpha-hydroxycleroda-3,13(14) Z-dien-15,16-olide from Polyalthia longifolia and its metabolite in hamster plasma: application to pharmacokinetic study. Biomed. Chromatogr 2012, 26:559-565.
4. Calle E.E., Rodriguez C., Walker-Thurmond K., Thun M.J. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N. Engl. J. Med 2003, 348:1625-1638.
5. Cole K.A., Harmon A.W., Harp J.B., Patel Y.M. Rb regulates C/EBPbeta-DNA-binding activity during 3T3-L1 adipogenesis. Am. J. Physiol. Cell Physiol 2004, 286:C349-C354.
6. Dave S., Kaur N.J., Nanduri R., Dkhar H.K., Kumar A., Gupta P. Inhibition of adipogenesis and induction of apoptosis and lipolysis by stem bromelain in 3T3-L1 adipocytes. PLoS ONE 2012, 7. e30831.
7. Ejaz A., Wu D., Kwan P., Meydani M. Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice. J. Nutr 2009, 139:919-925.
8. Fabbrini E., Sullivan S., Klein S. Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology 2010, 51:679-689.
9. Finucane F.M., Luan J., Wareham N.J., Sharp S.J., O'Rahilly S., Balkau B., et al. Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals. Diabetologia 2009, 52:2345-2349.
10. Gagnon A., Lau S., Sorisky A. Rapamycin-sensitive phase of 3T3-L1 preadipocyte differentiation after clonal expansion. J. Cell. Physiol 2001, 189:14-22.
11. Goel A., Parihar A., Mishra P., Varshney S., Nag P., Beg M., et al. Design and synthesis of novel pyranone-based insulin sensitizers exhibiting in vivo hepatoprotective activity. MedChemComm 2013, 4:1532-1536.
12. Hishida T., Nishizuka M., Osada S., Imagawa M. The role of C/EBPdelta in the early stages of adipogenesis. Biochimie 2009, 91:654-657.
13. Hsu C.L., Lin Y.J., Ho C.T., Yen G.C. Inhibitory effects of garcinol and pterostilbene on cell proliferation and adipogenesis in 3T3-L1 cells. Food Funct 2012, 3:49-57.
14. Hu Y., Davies G.E. Berberine increases expression of GATA-2 and GATA-3 during inhibition of adipocyte differentiation. Phytomedicine 2009, 16:864-873.
15. Hu Y., Davies G.E. Berberine inhibits adipogenesis in high-fat diet-induced obesity mice. Fitoterapia 2010, 81:358-366.
16. Jothy S.L., Aziz A., Chen Y., Sasidharan S. Antioxidant activity and hepatoprotective potential of polyalthia longifolia and cassia spectabilis leaves against paracetamol-induced liver injury. Evid. Based Complement. Alternat. Med 2012, 2012. 561284.
17. Jung C.H., Kim H., Ahn J., Jeon T.I., Lee D.H., Ha T.Y. Fisetin regulates obesity by targeting mTORC1 signaling. J. Nutr. Biochem 2013, 24:1547-1554.
18. Kanda Y., Hinata T., Kang S.W., Watanabe Y. Reactive oxygen species mediate adipocyte differentiation in mesenchymal stem cells. Life Sci 2011, 89:250-258.
19. Kawai M., Mushiake S., Bessho K., Murakami M., Namba N., Kokubu C., et al. Wnt/Lrp/beta-catenin signaling suppresses adipogenesis by inhibiting mutual activation of PPARgamma and C/EBPalpha. Biochem. Biophys. Res. Commun 2007, 363:276-282.
20. Kim C.Y., Le T.T., Chen C., Cheng J.X., Kim K.H. Curcumin inhibits adipocyte differentiation through modulation of mitotic clonal expansion. J. Nutr. Biochem 2011, 22:910-920.
21. Kopelman P.G. Obesity as a medical problem. Nature 2000, 404:635-643.
22. Kwon J.Y., Seo S.G., Yue S., Cheng J.X., Lee K.W., Kim K.H. An inhibitory effect of resveratrol in the mitotic clonal expansion and insulin signaling pathway in the early phase of adipogenesis. Nutr. Res 2012, 32:607-616.
23. Kwon J.Y., Seo S.G., Heo Y.S., Yue S., Cheng J.X., Lee K.W., et al. Piceatannol, natural polyphenolic stilbene, inhibits adipogenesis via modulation of mitotic clonal expansion and insulin receptor-dependent insulin signaling in early phase of differentiation. J. Biol. Chem 2012, 287:11566-11578.
24. Lee H., Lee Y.J., Choi H., Ko E.H., Kim J.W. Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion. J. Biol. Chem 2009, 284:10601-10609.
25. Lee H., Bae S., Yoon Y. The anti-adipogenic effects of (-)epigallocatechin gallate are dependent on the WNT/beta-catenin pathway. J. Nutr. Biochem 2013, 24:1232-1240.
26. Lefterova M.I., Zhang Y., Steger D.J., Schupp M., Schug J., Cristancho A., et al. PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale. Genes Dev 2008, 22:2941-2952.
27. Maffei M., Halaas J., Ravussin E., Pratley R.E., Lee G.H., Zhang Y., et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat. Med 1995, 1:1155-1161.
28. Malairajan P., Gopalakrishnan G., Narasimhan S., Veni K.J. Evalution of anti-ulcer activity of Polyalthia longifolia (Sonn.) Thwaites in experimental animals. Indian J. Pharmacol 2008, 40:126-128.
29. Mandal S., Rajani G.P., Sharma R.K., Gupta N. In vitro antioxidant and anti-inflammatory potential of Polyalthia longifolia in rats. Indian J. Pharmacol 2012, 44:277-278.
30. Manjula S.N., Kenganora M., Parihar V.K., Kumar S., Nayak P.G., Kumar N., et al. Antitumor and antioxidant activity of Polyalthia longifolia stem bark ethanol extract. Pharm. Biol 2010, 48:690-696.
31. Meydani M., Hasan S.T. Dietary polyphenols and obesity. Nutrients 2010, 2:737-751.
32. Min S.Y., Yang H., Seo S.G., Shin S.H., Chung M.Y., Kim J., et al. Cocoa polyphenols suppress adipogenesis in vitro and obesity in vivo by targeting insulin receptor. Int. J. Obes. (Lond) 2013, 37:584-592.
33. Nakata M., Nagasaka S., Kusaka I., Matsuoka H., Ishibashi S., Yada T. Effects of statins on the adipocyte maturation and expression of glucose transporter 4 (SLC2A4): implications in glycaemic control. Diabetologia 2006, 49:1881-1892.
34. Nishimura S., Manabe I., Nagasaki M., Hosoya Y., Yamashita H., Fujita H., et al. Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels. Diabetes 2007, 56:1517-1526.
35. Oh R.C., Lanier J.B. Management of Hypertriglyceridemia. Am. Fam. Physician 2007, 75:1365-1371.
36. Padwal R.S., Majumdar S.R. Drug treatments for obesity: orlistat, sibutramine, and rimonabant. Lancet 2007, 369:71-77.
37. Perobner I., Karow M., Jochum M., Neth P. LRP6 mediates Wnt/beta-catenin signaling and regulates adipogenic differentiation in human mesenchymal stem cells. Int. J. Biochem. Cell Biol 2012, 44:1970-1982.
38. Polak P., Cybulski N., Feige J.N., Auwerx J., Ruegg M.A., Hall M.N. Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. Cell Metab 2008, 8:399-410.
39. Prestwich T.C., Macdougald O.A. Wnt/beta-catenin signaling in adipogenesis and metabolism. Curr. Opin. Cell Biol 2007, 19:612-617.
40. Ross S.E., Erickson R.L., Gerin I., DeRose P.M., Bajnok L., Longo K.A., et al. Microarray analyses during adipogenesis: understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor alpha in adipocyte metabolism. Mol. Cell. Biol 2002, 22:5989-5999.
41. Sashidhara K.V., Singh S.P., Srivastava A., Puri A., Chhonker Y.S., Bhatta R.S., et al. Discovery of a new class of HMG-CoA reductase inhibitor from Polyalthia longifolia as potential lipid lowering agent. Eur. J. Med. Chem 2011, 46:5206-5211.
42. Satoh N., Naruse M., Usui T., Tagami T., Suganami T., Yamada K., et al. Leptin-to-adiponectin ratio as a potential atherogenic index in obese type 2 diabetic patients. Diabetes Care 2004, 27:2488-2490.
43. Schieke S.M., Phillips D., McCoy J.P., Aponte A.M., Shen R.F., Balaban R.S., et al. The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. J. Biol. Chem 2006, 281:27643-27652.
44. Seo J.B., Park S.W., Choe S.S., Jeong H.W., Park J.Y., Choi E.W., et al. Foenumoside B from Lysimachia foenum-graecum inhibits adipocyte differentiation and obesity induced by high-fat diet. Biochem. Biophys. Res. Commun 2012, 417:800-806.
45. Sherr C.J., Roberts J.M. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 1995, 9:1149-1163.
46. Spiegelman B.M., Flier J.S. Adipogenesis and obesity: rounding out the big picture. Cell 1996, 87:377-389.
47. Stephens J.M. The fat controller: adipocyte development. PLoS Biol 2012, 10. e1001436.
48. Takahashi S., Tamai M., Nakajima S., Kato H., Johno H., Nakamura T., et al. Blockade of adipocyte differentiation by cordycepin. Br. J. Pharmacol 2012, 167:561-575.
49. Tang Q.Q., Lane M.D. Adipogenesis: from stem cell to adipocyte. Annu. Rev. Biochem 2012, 81:715-736.
50. Tang Q.Q., Otto T.C., Lane M.D. CCAAT/enhancer-binding protein beta is required for mitotic clonal expansion during adipogenesis. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:850-855.
51. Tang Q.Q., Otto T.C., Lane M.D. Mitotic clonal expansion: a synchronous process required for adipogenesis. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:44-49.
52. Tormos K.V., Anso E., Hamanaka R.B., Eisenbart J., Joseph J., Kalyanaraman B., et al. Mitochondrial complex III ROS regulate adipocyte differentiation. Cell Metab 2011, 14:537-544.
53. Varshney S., Shankar K., Beg M., Balaramnavar V.M., Mishra S.K., Jagdale P., et al. Rohitukine inhibits in vitro adipogenesis arresting mitotic clonal expansionand improves dyslipidemia in vivo. J. Lipid Res 2014, 55:1019-1032.
54. Wang G., Liu X., Christoffel K.K., Zhang S., Wang B., Liu R., et al. Prediabetes is not all about obesity: association between plasma leptin and prediabetes in lean rural Chinese adults. Eur. J. Endocrinol 2010, 163:243-249.
55. White U.A., Stephens J.M. Transcriptional factors that promote formation of white adipose tissue. Mol. Cell. Endocrinol 2010, 318:10-14.
56. Xiang X., Zhao J., Xu G., Li Y., Zhang W. mTOR and the differentiation of mesenchymal stem cells. Acta Biochim. Biophys. Sin. (Shanghai) 2011, 43:501-510.
57. Yeh W.C., Cao Z., Classon M., McKnight S.L. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev 1995, 9:168-181.
58. Yu W., Chen Z., Zhang J., Zhang L., Ke H., Huang L., et al. Critical role of phosphoinositide 3-kinase cascade in adipogenesis of human mesenchymal stem cells. Mol. Cell. Biochem 2008, 310:11-18.
59. Zhang H.H., Huang J., Duvel K., Boback B., Wu S., Squillace R.M., et al. Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. PLoS ONE 2009, 4. e6189.