A withanolide coagulin-L inhibits adipogenesis modulating Wnt/β-catenin pathway and cell cycle in mitotic clonal expansion

Phytomedicine

Volumn 21, Issue 4, 2014, Pages 406-414

  Beg, Muheeb ^a   Chauhan, Parul ^a   Varshney, Salil ^a   Shankar, Kripa ^a   Rajan, Sujith ^a,b   Saini, Deepika ^a   Srivastava, M N ^a   Yadav, Prem P ^a   Gaikwad, Anil Nilkanth ^a,b  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH ACSIR   (India)

Author keywords

3T3 L1; Adipocytes; Adipogenesis; Coagulin L; Mitotic clonal expansion; Obesity; Withania coagulans

Indexed keywords

ANTIDIABETIC AGENT; BETA CATENIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; COAGULIN L; FAS ANTIGEN; GLUCOSE TRANSPORTER 4; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLANT EXTRACT; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRANSCRIPTION FACTOR GATA 2; UNCLASSIFIED DRUG; COAGULIN-L; CYCLIN DEPENDENT KINASE INHIBITOR 1B; TARGET OF RAPAMYCIN KINASE; WITHANOLIDE; WNT PROTEIN;

ADIPOGENESIS; ANIMAL CELL; ANTIDIABETIC ACTIVITY; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CELL EXPANSION; CELL PROLIFERATION; CELL STRAIN 3T3; CONTROLLED STUDY; ENZYME INHIBITION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPID STORAGE; MEDICINAL PLANT; MESENCHYMAL STEM CELL; METABOLIC SYNDROME X; MITOTIC CLONAL EXPANSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; S PHASE CELL CYCLE CHECKPOINT; UPREGULATION; WITHANIA COAGULANS; WNT SIGNALING PATHWAY; 3T3 CELL LINE; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; METABOLISM; MITOSIS; MOUSE; OBESITY; PHYTOTHERAPY; STEM CELL; WITHANIA;

WITHANIA COAGULANS;

3T3-L1 CELLS; ADIPOGENESIS; ANIMALS; BETA CATENIN; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CYCLIN-DEPENDENT KINASE INHIBITOR P27; HUMANS; MICE; MITOSIS; OBESITY; PHYTOTHERAPY; PLANT EXTRACTS; PPAR GAMMA; STEM CELLS; TOR SERINE-THREONINE KINASES; WITHANIA; WITHANOLIDES; WNT PROTEINS;

EID: 84897421717     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2013.10.009     Document Type: Article

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