Anticancer effect of calycopterin via PI3K/Akt and MAPK signaling pathways, ROS-mediated pathway and mitochondrial dysfunction in hepatoblastoma cancer (HepG2) cells

Molecular and Cellular Biochemistry

Volumn 397, Issue 1-2, 2014, Pages 17-31

  Esmaeili, Mohammad Ali ^a   Farimani, Mahdi Moridi ^a   Kiaei, Mahmoud ^b  

^a SHAHID BEHESHTI UNIVERSITY   (Iran)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Apoptosis; Calycopterin; HepG2; Mitochondria dysfunction; PI3K Akt; ROS

Indexed keywords

5,4' DIHYDROXY 3,6,7,8 TETRAMETHOXYFLAVONE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CELL DIVISION CYCLE 25 HOMOLOG C PHOSPHATASE; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; CYTOCHROME C; FLAVONOID; GENOMIC DNA; GLUTATHIONE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; CALYCOPTERIN; FLAVONE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL GROWTH; CELL VIABILITY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA FRAGMENTATION; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; G2 PHASE CELL CYCLE CHECKPOINT; GROWTH INHIBITION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LIVER CELL CARCINOMA; M PHASE CELL CYCLE CHECKPOINT; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN CLEAVAGE; PROTEIN DEPLETION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; DIET THERAPY; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HEPATOBLASTOMA; LIVER MITOCHONDRION; LIVER TUMOR; METABOLISM; PATHOLOGY;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; FLAVONES; HEP G2 CELLS; HEPATOBLASTOMA; HUMANS; LIVER NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MITOCHONDRIA, LIVER; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES;

EID: 84912019027     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-014-2166-4     Document Type: Article

References (42)

1. Kasibhatla S, Tseng B (2003) Why target apoptosis in cancer treatment. Mol Cancer Ther 2:573–580
2. Kerr JF, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239–257
3. Ghobrial IM, Witzig TE, Adjei AA (2005) Targeting apoptosis pathways in cancer therapy. CA Cancer J Clin 55:178–194
4. Reed JC (2000) Mechanisms of apoptosis. Am J Pathol 157:1415–1430
5. Evan GI, Vousden KH (2001) Proliferation cell cycle and apoptosis in cancer. Nature 411:342–348
6. Circu ML, Aw TY (2001) Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med 48:749–762
7. Scorrano L, Korsmeyer SJ (2003) Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. Biochem Biophys Res Commun 9:437–444
8. Lee KH (2010) Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach. J Nat Prod 73:500–516
9. Karrer W, Venkataraman K (1935) Identity of calycopterin and thapsin. Nature 135:878
10. Ratnagiriswaran AN, Sehra KB, Venkataraman K (1934) The anthelminthic constituent of the leaves of Calycopteris floribunda. Biohem J 28:1964–1967
11. Feng X, Liang N, Zhu D, Gao Q, Peng L, Dong H, Yue Q, Liu H, Bao J, Zhang J, Hao J, Gao Y, Yu X, Sun J (2013) Resveratrol inhibits β-amyloid-induced neuronal apoptosis through regulation of SIRT1-ROCK1 signaling pathway. PLoS ONE 8:e9888
12. Zhang W, Wang X, Chen T (2012) Resveratrol induces apoptosis via a Bak-mediated intrinsic pathway in human lung adenocarcinoma cells. Cell Signal 24:1037–1046
13. Kiaei M, Kipiani K, Petri S, Chen J, Calingasan NY, Beal MF (2005) Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis. Neurodegener Dis 2:246–254
14. Paris D, Ganey NJ, Laporte V, Patel NS, Beaulieu-Abdelahad D, Bachmeier CA, March a, Ait-Ghezala G, Mullan MJ (2010) Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model o Alzheimer’s disease. J Neuroinflamm 8:7–17
15. Lofrumento DD, Nicolardi G, Cianciulli A, De Nuccio F, La Pesa V, Carofiglio V, Dragone T, Calvello R, Panaro MA (2014) Neuroprotective effects of resveratrol in an MPTP mouse model of Parkinson’s-like disease: possible role of SOCS-1 in reducing pro-inflammatory responses. Innate Immun 20:249–260
16. Sethi G, Ahn KS, Pandey MK, Aggarwal BB (2007) Celastrol a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation. Blood 109:2727–2735
17. Sha M, Ye J, Zhang LX, Luan ZY, Chen YB (2013) Celastrol induces apoptosis of gastric cancer cells by miR-146a inhibition of NF-κB activity. Cancer Cell Int 13:50–55
18. Yan FG, Wang M, Li JM, Cheng H, SuL J, Wang X, Wu H, Xia L, Li X, Chang HC, Li Q (2012) Gambogenic acid induced mitochondrial-dependent apoptosis and referred to Phospho-Erk1/2 and Phospho-p38 MAPK in human hepatoma HepG2 cells. Environ Toxicol Pharmacol 33:181–190
19. Mihara M, Moll UN (2013) Detection of mitochondrial localization of p 53. Methods Mol Biol 234:203–209
20. Farimani MM, Namazi Sarvestani N, Ansari N, Khodagholi F (2011) Calycopterin promotes survival and outgrowth of neuron-like PC12 cells by attenuation of oxidative- and ER-stress-induced apoptosis along with inflammatory response. Chem Res Toxicol 24:2280–2292
21. Sarvestani NN, Khodagholi F, Ansari N, Farimani MN (2013) Involvement of p-CREB and phase II detoxifying enzyme system in neuroprotection mediated by the flavonoid calycopterin isolated from Dracocephalumkotschyi. Phytomedicine 15:939–946
22. Lammer C, Wagerer S, Saffrich R, Mertens D, Ansorge W, Hoffmann I (1998) The cdc25B phosphatase is essential for the G2/M phase transition in human cells. J Cell Sci 111:2445–2453
23. Sgarlata C, Pérez-Martín J (2005) The cdc25 phosphatase is essential for the G2/M phase transition in the basidiomycete yeast Ustilago maydis. Mol Microbiol 58:1482–1496
24. Jiang X, Wang X (2004) Cytochrome C mediated apoptosis. Annu Rev Biochem 73:87–106
25. Goping IS, Gross A, Lavoie JN, Nguyen M, Jemmerson R, Roth K (1998) Regulated targeting of BAX to mitochondria. J Cell Biol 143:207–215
26. Shimizu S, Narita M, Tsujimoto Y (1999) Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 3:483–487
27. Kuwana T, Newmeyer DD (2003) Bcl-2-family proteins and the role of mitochondria in apoptosis. Curr Opin Cell Biol 15:691–699
28. Swamy SM, Huat BT (2003) Intracellular glutathione depletion and reactive oxygen species generation are important in alpha-hederin-induced apoptosis of P388 cells. Mol Cell Biochem 245:127–139
29. Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, Reed JC (1998) Regulation of cell death protease caspase-9 by phosphorylation. Science 282:1318–1321
30. Kowaltowski AJ, Vercesi AE, Fiskum G (2000) Bcl-2 prevents mitochondrial permeability transition and cytochrome c release via maintenance of reduced pyridine nucleotides. Cell Death Differ 7:903–910
31. Atten MJ, Godoy-Romero E, Attar BM, Milson T, Zopel M, Holian O (2005) Resveratrol regulates cellular PKC alpha and delta to inhibit growth and induce apoptosis in gastric cancer cells. Invest New Drugs 23:111–119
32. Sampath D, Rao VA, Plunkett W (2003) Mechanisms of apoptosis induction by nucleoside analogs. Oncogene 22:9063–9074
33. Naowaratwattana W, De-Eknamkul W, De Mejia EG (2013) Phenolic-containing organic extracts of mulberry (Morus alba L.) leaves inhibit HepG2 hepatoma cells through G2/M phase arrest, induction of apoptosis, and inhibition of topoisomerase II alpha activity. J Med Food 13:1045–1056
34. Porter AG, Janicke RU (1999) Emerging roles of caspase-3 in apoptosis. Cell Death Differ 6:99–104
35. Hussain AR, Al-Rasheed PS, Manogaran M, Al-Hussein KA, Platanias LC, Al Uddin S (2006) Curcumin induces apoptosis via inhibition of PI3’- kinase/AKT pathway in acute T cell leukemias. Apoptosis 11:245–254
36. Gururajan M, Dasu T, Shahidain S, Jennings CD, Robertson DA, Rangnekar VM, Bondada S (2007) Spleen tyrosine kinase (Syk), a novel target of curcumin, is required for B lymphoma growth. J Immunol 178:111–121
37. Johnson GL, Lapadat R (2002) Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298:1911–1912
38. Hirose Y, Katayama M, Stokoe D, Haas-Kogan DA, Berger MS, Pieper RO (2003) The p38 mitogen-activated protein kinase pathway links the DNA mismatch repair system to the G2 checkpoint and to resistance to chemotherapeutic DNA-methylating agents. Mol Cell Biol 23:8306–8315
39. Chang L, Karin M (2001) Mammalian MAP kinase signaling cascades. Nature 410:37–40
40. Wei F, Xie Y, Tao L, Tang D (2010) Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation. Cell Signal 22:1783–1789
41. Shaul YD, Seger R (2005) The MEK/ERK cascade: from signaling specificity to diverse functions. Biochim Biophys Acta 1773:1213–1226
42. Kumar S, Jiang MS, Adams JL, Lee JC (1999) Pyridinylimidazole compound SB 203580 inhibits the activity but not the activation of p38 mitogen-activated protein kinase. Biochem Biophys Res Commun 263:825–831