Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetase

Journal of Structural and Functional Genomics

Volumn 15, Issue 4, 2014, Pages 181-190

  Jain, Vitul ^a   Kikuchi, Haruhisa ^b   Oshima, Yoshiteru ^b   Sharma, Amit ^a   Yogavel, Manickam ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

Crystal structure; Halofuginone; Inhibition; Malaria; Protein translation

Indexed keywords

AMINO ACID TRANSFER RNA LIGASE; HALOFUGINONE; PROLYL TRNA SYNTHETASE; UNCLASSIFIED DRUG; ANTIMALARIAL AGENT; ENZYME INHIBITOR; FEBRIFUGINE; PIPERIDINE DERIVATIVE; PROLYL T RNA SYNTHETASE; PROTOZOAL PROTEIN; QUINAZOLINE DERIVATIVE;

ARTICLE; CRYSTALLOGRAPHY; CYTOPLASM; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME LOCALIZATION; ENZYME STRUCTURE; IMMUNOFLUORESCENCE; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ANALYSIS; ANTAGONISTS AND INHIBITORS; CHEMISTRY; ENZYMOLOGY; MALARIA, FALCIPARUM; X RAY CRYSTALLOGRAPHY;

AMINO ACYL-TRNA SYNTHETASES; ANTIMALARIALS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; MALARIA, FALCIPARUM; PIPERIDINES; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; QUINAZOLINES;

EID: 84911982975     PISSN: 1345711X     EISSN: 15700267     Source Type: Journal    
DOI: 10.1007/s10969-014-9186-x     Document Type: Article

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