Synthesis and evaluation of 4-quinazolinone compounds as potential antimalarial agents

European Journal of Medicinal Chemistry

Volumn 45, Issue 9, 2010, Pages 3864-3869

  Zhu, Shuren ^a   Wang, Joe ^a   Chandrashekar, Gudise ^a   Smith, Erika ^a   Liu, Xianjun ^b   Zhang, Yongshen ^c  

^a Radix Pharmaceuticals Inc   (United States)

^b True PharmaChem Inc   (United States)

^c INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

Drug design; Febrifugine; Malaria chemotherapy; Plasmodium falciparum

Indexed keywords

3 [2 (3 BENZYLOXYPIPERIDIN 2 YL) 2 OXOETHYL] 3H PYRIDO[3,2 DEXTRO]PYRIMIDIN 4 ONE; 3 [2 (3 BENZYLOXYPIPERIDIN 2 YL) 2 OXOETHYL] 5 TRIFLUOROMETHYL 3H QUINAZOLIN 4 ONE; 3 [2 (3 ETHOXYPIPERIDIN 2 YL) 2 OXOETHYL] 3H QUINAZOLIN 4 ONE; 3 [2 (3 ETHOXYPIPERIDIN 2 YL) 2 OXOETHYL] 5 FLUORO 3H QUINAZOLIN 4 ONE; 3 [2 (3 ETHOXYPIPERIDIN 2 YL) 2 OXOETHYL] 8 METHOXY 3H QUINAZOLIN 4 ONE; 3 [2 (3 HYDROXYPIPERIDIN 2 YL) 2 OXOETHYL] 3H PYRIDO[2,3 DEXTRO]PYRIMIDIN 4 ONE; 3 [2 (3 HYDROXYPIPERIDIN 2 YL) 2 OXOETHYL] 3H PYRIDO[3,2 DEXTRO]PYRIMIDIN 4 ONE; 3 [2 (3 HYDROXYPIPERIDIN 2 YL) 2 OXOETHYL] 3H PYRIDO[4,3 DEXTRO]PYRIMIDIN 4 ONE; 3 [2 (3 HYDROXYPIPERIDIN 2 YL) 2 OXOETHYL] 3H QUINAZOLIN 4 ONE; 3 [2 (3 HYDROXYPIPERIDIN 2 YL) 2 OXOETHYL] 5 TRIFLUOROMETHYL 3H QUINAZOLIN 4 ONE; 3 [2 (3 HYDROXYPIPERIDIN 2 YL) 2 OXOETHYL] 7 METHOXY 3H QUINAZOLIN 4 ONE; 3 BENZYLOXY 2 [1 HYDROXY 2 (4 OXO 4H QUINAZOLIN 3 YL) ETHYL] PIPERIDINE 1 CARBOXYLIC ACID BENZYL ESTER; 3 BENZYLOXY 2 FORMYLPIPERIDINE 1 CARBOXYLIC ACID BENZYL ESTER; 3 BENZYLOXY 2 OXIRANYLPIPERIDINE 1 CARBOXYLIC ACID BENZYL ESTER; 3 BENZYLOXY 2 VINYLPIPERIDINE 1 CARBOXYLIC ACID BENZYL ESTER; 4(3H) QUINAZOLINONE DERIVATIVE; 5 FLUORO 3 [2 (3 HYDROXYPIPERIDIN 2 YL) 2 OXOETHYL] 3H QUINAZOLIN 4 ONE; ANTIMALARIAL AGENT; CHLOROQUINE; FEBRIFUGINE; QUINAZOLINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CHEMOTHERAPY; CHINESE HERB; CONTROLLED STUDY; DICHROA FEBRIFUGA; DRUG EFFICACY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MALARIA FALCIPARUM; MOUSE; NONHUMAN; PLASMODIUM BERGHEI INFECTION; PLASMODIUM FALCIPARUM; TOXICITY TESTING;

ANIMALS; ANTIMALARIALS; CELL LINE; DRUG EVALUATION, PRECLINICAL; MICE; MICE, INBRED ICR; PLASMODIUM FALCIPARUM; QUINAZOLINONES;

EID: 77955557070     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.05.040     Document Type: Article

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