Ligand-bound structures provide atomic snapshots for the catalytic mechanism of D-amino acid deacylase

Journal of Biological Chemistry

Volumn 285, Issue 8, 2010, Pages 5917-5930

  Bhatt, Tarun Kumar ^a   Yogavel, Manickam ^a   Wydau, Sandra ^b   Berwal, Ritu ^a   Sharma, Amit ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY ICGEB   (India)

^b LABORATOIRE DE BIOCHIMIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE POCKET; BOUND STRUCTURE; CATALYTIC MECHANISMS; D-AMINO ACID; DEACYLATION; GROWTH INHIBITION; IN-DEPTH ANALYSIS; LIGAND RECOGNITION; MALARIA PARASITE; PARASITE-; PLASMODIUM FALCIPARUM; RE-ORIENTATION; STRUCTURAL BASIS; STRUCTURAL INSIGHTS; STRUCTURE-BASED; SUBSITES;

AMINO ACIDS; CATALYSIS; ENZYMES; ISOMERS; LEAD COMPOUNDS; LIGANDS; ORGANIC ACIDS; QUANTUM CHEMISTRY;

ENZYME INHIBITION;

ADENOSINE; AMINO ACID DEACYLASE; AMINO ACID DERIVATIVE; MICROORGANISM PROTEIN; TRANSFER RNA; UNCLASSIFIED DRUG; HYDROLASE; PROTOZOAL PROTEIN;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DEACYLATION; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; GROWTH INHIBITION; LIGAND BINDING; MOLECULAR DOCKING; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; CHEMISTRY; ENZYMOLOGY; METABOLISM; STRUCTURE ACTIVITY RELATION;

PLASMODIUM FALCIPARUM;

ADENOSINE; CATALYSIS; CATALYTIC DOMAIN; HYDROLASES; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77949325165     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.038562     Document Type: Article

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