Pellino1-mediated TGF-β1 synthesis contributes to mechanical stress induced cardiac fibroblast activation

Journal of Molecular and Cellular Cardiology

Volumn 79, Issue , 2015, Pages 145-156

  Song, Juan ^a   Zhu, Yun ^b   Li, Jiantao ^a   Liu, Jiahao ^a   Gao, Yun ^a   Ha, Tuanzhu ^c   Que, Linli ^a   Liu, Li ^d   Zhu, Guoqing ^a   Chen, Qi ^a   Xu, Yong ^a   Li, Chuanfu ^c   Li, Yuehua ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b JIANGSU INSTITUTE OF NUCLEAR MEDICINE   (China)

^c East Tennessee State University   (United States)

^d THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Cardiac fibroblasts; Cardiac fibrosis; Mechanical stretch; Pellino1; TGF 1

Indexed keywords

ADENOVIRUS VECTOR; ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PELLINO 1; RECEPTOR INTERACTING PROTEIN 140; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; COLLAGEN; MITOGEN ACTIVATED PROTEIN KINASE P38; NUCLEAR PROTEIN; PELLINO1 PROTEIN, RAT; POLYUBIQUITIN; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE; RIP1 PROTEIN, RAT; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; FIBROBLAST; HEART DISEASE; HEART EJECTION FRACTION; HEART HEMODYNAMICS; HEART LEFT VENTRICLE OVERLOAD; HEART MUSCLE FIBROSIS; HEART VENTRICLE ENDDIASTOLIC PRESSURE; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE OVERLOAD; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MECHANICAL STRESS; NONHUMAN; PRESSURE GRADIENT; PROMOTER REGION; PROTEIN BINDING; PROTEIN CONTENT; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; THORACOTOMY; TRANSACTIVATION; UBIQUITINATION; VIRAL GENE DELIVERY SYSTEM; VIRUS GENE; ADENOVIRIDAE; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; BIOSYNTHESIS; CELL DIFFERENTIATION; FIBROSIS; GENE SILENCING; GENETICS; HEART; HEART MUSCLE; METABOLISM; NEWBORN; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; PRESSURE; SPRAGUE DAWLEY RAT;

ADENOVIRIDAE; ANIMALS; ANIMALS, NEWBORN; CELL DIFFERENTIATION; COLLAGEN; FIBROBLASTS; FIBROSIS; GENE SILENCING; HEART; MALE; MODELS, BIOLOGICAL; MYOCARDIUM; NF-KAPPA B; NUCLEAR PROTEINS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; POLYUBIQUITIN; PRESSURE; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; RATS, SPRAGUE-DAWLEY; STRESS, MECHANICAL; TNF RECEPTOR-ASSOCIATED FACTOR 6; TRANSCRIPTION FACTOR AP-1; TRANSFORMING GROWTH FACTOR BETA1; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84911980759     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2014.11.006     Document Type: Article

References (43)

1. Morisco C., Sadoshima J., Trimarco B., Arora R., Vatner D.E., Vatner S.F. Is treating cardiac hypertrophy salutary or detrimental: the two faces of Janus. Am J Physiol Heart Circ Physiol 04-01-2003, 284(4):H1043-H1047.
2. Burchfield J.S., Xie M., Hill J.A. Pathological ventricular remodeling: mechanisms: part 1 of 2. Circulation 07-23-2013, 128(4):388-400.
3. Baudino T.A., Carver W., Giles W., Borg T.K. Cardiac fibroblasts: friend or foe?. Am J Physiol Heart Circ Physiol 09-01-2006, 291(3):H1015-H1026.
4. Porter K.E., Turner N.A. Cardiac fibroblasts: at the heart of myocardial remodeling. Pharmacol Ther 08-01-2009, 123(2):255-278.
5. Bujak M., Frangogiannis N.G. The role of TGF-beta signaling in myocardial infarction and cardiac remodeling. Cardiovasc Res 05-01-2007, 74(2):184-195.
6. Huang X.R., Chung A.C., Yang F., Yue W., Deng C., Lau C.P., et al. Smad3 mediates cardiac inflammation and fibrosis in angiotensin II-induced hypertensive cardiac remodeling. Hypertension 05-01-2010, 55(5):1165-1171.
7. Ruwhof C., van Wamel A.E., Egas J.M., van der Laarse A. Cyclic stretch induces the release of growth promoting factors from cultured neonatal cardiomyocytes and cardiac fibroblasts. Mol Cell Biochem 05-01-2000, 208(1-2):89-98.
8. Lee K.Y., Ito K., Hayashi R., Jazrawi E.P., Barnes P.J., Adcock I.M. NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription. J Immunol 01-01-2006, 176(1):603-615.
9. Schauvliege R., Janssens S., Beyaert R. Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases. FEBS Lett 08-21-2006, 580(19):4697-4702.
10. Jiang Z., Johnson H.J., Nie H., Qin J., Bird T.A., Li X. Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex. J Biol Chem 03-28-2003, 278(13):10952-10956.
11. Choi K.C., Lee Y.S., Lim S., Choi H.K., Lee C.H., Lee E.K., et al. Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1. Nat Immunol 10-01-2006, 7(10):1057-1065.
12. Xiao Y., Jin J., Chang M., Chang J.H., Hu H., Zhou X., et al. Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation. Nat Med 05-01-2013, 19(5):595-602.
13. Li Y., Ha T., Gao X., Kelley J., Williams D.L., Browder I.W., et al. NF-kappaB activation is required for the development of cardiac hypertrophy in vivo. Am J Physiol Heart Circ Physiol 10-01-2004, 287(4):H1712-H1720.
14. Lebeche D., Kaprielian R., Tomaselli G., Del M.F., Gwathmey J.K., Schwartz A., et al. In vivo cardiac gene transfer of Kv4.3 abrogates the hypertrophic response in rats after aortic stenosis. Circulation 11-30-2004, 110(22):3435-3443.
15. Weber K.T., Brilla C.G., Campbell S.E., Zhou G., Matsubara L., Guarda E. Pathologic hypertrophy with fibrosis: the structural basis for myocardial failure. Blood Press 08-01-1992, 1(2):75-85.
16. Lopez B., Gonzalez A., Hermida N., Valencia F., de Teresa E., Diez J. Role of lysyl oxidase in myocardial fibrosis: from basic science to clinical aspects. Am J Physiol Heart Circ Physiol 07-01-2010, 299(1):H1-H9.
17. Creemers E.E., Pinto Y.M. Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart. Cardiovasc Res 02-01-2011, 89(2):265-272.
18. Chang M., Jin W., Sun S.C. Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Nat Immunol 10-01-2009, 10(10):1089-1095.
19. Chen H.N., Wang D.J., Ren M.Y., Wang Q.L., Sui S.J. TWEAK/Fn14 promotes the proliferation and collagen synthesis of rat cardiac fibroblasts via the NF-small ka, CyrillicB pathway. Mol Biol Rep 08-01-2012, 39(8):8231-8241.
20. Deb A., Ubil E. Cardiac fibroblast in development and wound healing. J Mol Cell Cardiol 05-01-2014, 70:47-55.
21. Moynagh P.N. The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling. Trends Immunol 01-01-2009, 30(1):33-42.
22. Schauvliege R., Janssens S., Beyaert R. Pellino proteins: novel players in TLR and IL-1R signalling. J Cell Mol Med 05-01-2007, 11(3):453-461.
23. Zhu Y., Li T., Song J., Liu C., Hu Y., Que L., et al. The TIR/BB-loop mimetic AS-1 prevents cardiac hypertrophy by inhibiting IL-1R-mediated MyD88-dependent signaling. Basic Res Cardiol 09-01-2011, 106(5):787-799.
24. Zelarayan L., Renger A., Noack C., Zafiriou M.P., Gehrke C., van der Nagel R., et al. NF-kappaB activation is required for adaptive cardiac hypertrophy. Cardiovasc Res 12-01-2009, 84(3):416-424.
25. Heineke J., Molkentin J.D. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol 08-01-2006, 7(8):589-600.
26. Esposito G., Perrino C., Schiattarella G.G., Belardo L., di Pietro E., Franzone A., et al. Induction of mitogen-activated protein kinases is proportional to the amount of pressure overload. Hypertension 01-01-2010, 55(1):137-143.
27. Wu W., Hu Y., Li J., Zhu W., Ha T., Que L., et al. Silencing of Pellino1 improves post-infarct cardiac dysfunction and attenuates left ventricular remodelling in mice. Cardiovasc Res 04-01-2014, 102:46-55.
28. Herum K.M., Lunde I.G., Skrbic B., Florholmen G., Behmen D., Sjaastad I., et al. Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress. J Mol Cell Cardiol 01-01-2013, 54:73-81.
29. Weber K.T., Sun Y., Bhattacharya S.K., Ahokas R.A., Gerling I.C. Myofibroblast-mediated mechanisms of pathological remodelling of the heart. Nat Rev Cardiol 01-01-2013, 10(1):15-26.
30. Leemans J.C., Butter L.M., Pulskens W.P., Teske G.J., Claessen N., van der Poll T., et al. The role of Toll-like receptor 2 in inflammation and fibrosis during progressive renal injury. PLoS ONE 01-20-2009, 4(5):e5704.
31. Sugiura H., Ichikawa T., Koarai A., Yanagisawa S., Minakata Y., Matsunaga K., et al. Activation of Toll-like receptor 3 augments myofibroblast differentiation. Am J Respir Cell Mol Biol 06-01-2009, 40(6):654-662.
32. Pulskens W.P., Rampanelli E., Teske G.J., Butter L.M., Claessen N., Luirink I.K., et al. TLR4 promotes fibrosis but attenuates tubular damage in progressive renal injury. J Am Soc Nephrol 08-01-2010, 21(8):1299-1308.
33. Jin W., Chang M., Sun S.C. Peli: a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance. Cell Mol Immunol 03-01-2012, 9(2):113-122.
34. Adhikari A., Xu M., Chen Z.J. Ubiquitin-mediated activation of TAK1 and IKK. Oncogene 05-14-2007, 26(22):3214-3226.
35. Vesely P.W., Staber P.B., Hoefler G., Kenner L. Translational regulation mechanisms of AP-1 proteins. Mutat Res 07-01-2009, 682(1):7-12.
36. Huang D., Wang Y., Yang C., Liao Y., Huang K. Angiotensin II promotes poly(ADP-ribosyl)ation of c-Jun/c-Fos in cardiac fibroblasts. J Mol Cell Cardiol 01-01-2009, 46(1):25-32.
37. Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem 07-14-1995, 270(28):16483-16486.
38. McDermott E.P., O'Neill L.A. Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1. J Biol Chem 03-08-2002, 277(10):7808-7815.
39. Tanos T., Marinissen M.J., Leskow F.C., Hochbaum D., Martinetto H., Gutkind J.S., et al. Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light. J Biol Chem 05-13-2005, 280(19):18842-18852.
40. Calleros L., Lasa M., Toro M.J., Chiloeches A. Low cell cholesterol levels increase NFkappaB activity through a p38 MAPK-dependent mechanism. Cell Signal 12-01-2006, 18(12):2292-2301.
41. Li J.M., Brooks G. Differential protein expression and subcellular distribution of TGFbeta1, beta2 and beta3 in cardiomyocytes during pressure overload-induced hypertrophy. J Mol Cell Cardiol 08-01-1997, 29(8):2213-2224.
42. Pauschinger M., Knopf D., Petschauer S., Doerner A., Poller W., Schwimmbeck P.L., et al. Dilated cardiomyopathy is associated with significant changes in collagen type I/III ratio. Circulation 06-01-1999, 99(21):2750-2756.
43. Kuwahara F., Kai H., Tokuda K., Kai M., Takeshita A., Egashira K., et al. Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats. Circulation 07-02-2002, 106(1):130-135.