The TIR/BB-loop mimetic AS-1 prevents cardiac hypertrophy by inhibiting IL-1R-mediated MyD88-dependent signaling

Basic Research in Cardiology

Volumn 106, Issue 5, 2011, Pages 787-799

  Zhu, Yun ^a   Li, Ting ^a   Song, Juan ^a   Liu, Chunyang ^a   Hu, Yulong ^a   Que, Lingli ^a   Ha, Tuanzhu ^b   Kelley, Jim ^b   Chen, Qi ^a   Li, Chuanfu ^b   Li, Yuehua ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b East Tennessee State University   (United States)

Author keywords

IL 1R; Left ventricular hypertrophy; MyD88; NF B; TIR BB Loop mimetic

Indexed keywords

HYDROCINNAMOYLVALYLPYRROLIDINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOID DIFFERENTIATION FACTOR 88; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; HEART DISEASE; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE OVERLOAD; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NEWBORN; NONHUMAN; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; BIOMIMETICS; CARDIOMEGALY; CELLS, CULTURED; DISEASE MODELS, ANIMAL; INTERLEUKIN-1BETA; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MYELOID DIFFERENTIATION FACTOR 88; MYOCYTES, CARDIAC; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, INTERLEUKIN-1; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS; VALINE;

EID: 80054709618     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-011-0182-z     Document Type: Article

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