TWEAK/Fn14 promotes the proliferation and collagen synthesis of rat cardiac fibroblasts via the NF-kB pathway

Molecular Biology Reports

Volumn 39, Issue 8, 2012, Pages 8231-8241

  Chen, Hui Na ^a   Wang, De Jin ^a   Ren, Man Yi ^b   Wang, Qi Lei ^a   Sui, Shu Jian ^a  

^a THE SECOND HOSPITAL OF SHANDONG UNIVERSITY   (China)

^b SHANDONG PROVINCIAL CHEST HOSPITAL   (China)

Author keywords

Cardiac fibroblasts; Collagen synthesis; Fn14; Myocardial fibrosis; NF kB; TWEAK

Indexed keywords

AMMONIUM PYRROLIDINE DITHIOCARBAMATE; DITHIOCARBAMIC ACID; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR INDUCIBLE MOLECULE 14; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR LIKE WEAK INDUCER OF APOPTOSIS; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; COLLAGEN; MEMBRANE PROTEIN; MESSENGER RNA; TUMOR NECROSIS FACTOR RECEPTOR; TWEAK PROTEIN, RAT; TWEAK RECEPTOR;

ANIMAL CELL; ARTICLE; CARDIAC FIBROBLAST; CELL PROLIFERATION; CELL STIMULATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SYNTHESIS; FIBROBLAST; HEART MUSCLE FIBROSIS; NEWBORN; NONHUMAN; PROTEIN INDUCTION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; BIOSYNTHESIS; GENETICS; HEART MUSCLE; METABOLISM;

RATTUS;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; CELL PROLIFERATION; COLLAGEN; FIBROBLASTS; MATRIX METALLOPROTEINASE 9; MEMBRANE PROTEINS; MYOCARDIUM; NF-KAPPA B; RATS; RECEPTORS, TUMOR NECROSIS FACTOR; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTORS;

EID: 84868659783     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-1671-3     Document Type: Article

References (54)

1. Xu X, Pang J, Yin H, et al. (2007) Hexarelin suppresses cardiac fibroblast proliferation and collagen synthesis in rat. Am J Physiol Heart Circ Physiol 293:H2952-H2958
2. Spinale FG (2002) Matrix metalloproteinases: regulation and dysregulation in the failing heart. Circ Res 90:520-530
3. Leask A (2010) Potential therapeutic targets for cardiac fibrosis: TGF-beta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation. Circ Res 106:1675-1680
4. Burkly LC, Michaelson JS, Hahm K, et al. (2007) TWEAKing tissue remodeling by a multifunctional cytokine: role of TWEAK/Fn14 pathway in health and disease. Cytokine 40:1-16
5. Wiley SR, Cassiano L, Lofton T, et al. (2001) A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. Immunity 15:837-846
6. Petitbarat M, Rahmati M, Serazin V, et al. (2011) TWEAK appears as a modulator of endometrial IL-18 related cytotoxic activity of uterine natural killers. PLoS ONE 6:e14497
7. Ando T, Ichikawa J, Wako M, et al. (2006) TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cells. Arthritis Res Ther 8:R146
8. Dogra C, Changotra H, Wedhas N, et al. (2007) TNF-related weak inducer of apoptosis (TWEAK) is a potent skeletal muscle-wasting cytokine. FASEB J 21:1857-1869
9. Brown SA, Richards CM, Hanscom HN, et al. (2003) The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation. Biochem J 371:395-403
10. Han S, Yoon K, Lee K, et al. (2003) TNF-related weak inducer of apoptosis receptor, a TNF receptor superfamily member, activates NF-kappaB through TNF receptor-associated factors. Biochem Biophys Res Commun 305:789-796
11. Winkles JA (2008) The TWEAK-Fn14 cytokine-receptor axis: discovery, biology and therapeutic targeting. Nat Rev Drug Discov 7:411-425
12. Campbell S, Burkly LC, Gao HX, et al. (2006) Proinflammatory effects of TWEAK/Fn14 interactions in glomerular mesangial cells. J Immunol 176:1889-1898
13. Ebihara N, Nakayama M, Tokura T, et al. (2009) Expression and function of fibroblast growth factor-inducible 14 in human corneal myofibroblasts. Exp Eye Res 89:256-262
14. Mustonen E, Sakkinen H, Tokola H, et al. (2010) Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14 during cardiac remodelling in rats. Acta Physiol (Oxf) 199:11-22
15. Jain M, Jakubowski A, Cui L, et al. (2009) A novel role for tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in the development of cardiac dysfunction and failure. Circulation 119:2058-2068
16. Ocaranza MP, Diaz-Araya G, Carreno JE, et al. (2004) Polymorphism in gene coding for ACE determines different development of myocardial fibrosis in rats. Am J Physiol Heart Circ Physiol 286:H498-H506
17. Gagnon C, Legault F, Geraldes P, et al. (2004) Diverse effects of Ace inhibitors and angiotensin II receptor antagonists on prevention of cardiac hypertrophy and collagen distribution in spontaneously hypertensive rats. Int J Cardiol 97:373-381
18. Li YY, Feng YQ, Kadokami T, et al. (2000) Myocardial extracellular matrix remodeling in transgenic mice overexpressing tumor necrosis factor alpha can be modulated by anti-tumor necrosis factor alpha therapy. Proc Natl Acad Sci 97:12746-12751
19. Eberhardt W, Huwiler A, Beck KF, et al. (2000) Amplification of IL-1 beta-induced matrix metalloproteinase-9 expression by superoxide in rat glomerular mesangial cells is mediated by increased activities of NF-kappaB and activating protein-1 and involves activation of the mitogen-activated protein kinase pathways. J Immunol 165:5788-5797
20. Vellaichamy E, Khurana ML, Fink J, et al. (2005) Involvement of the NF-kappaB/matrix metalloproteinase pathway in cardiac fibrosis of mice lacking guanylyl cyclase/natriuretic peptide receptor A. J Biol Chem 280:19230-19242
21. Saitoh T, Nakayama M, Nakano H, et al. (2003) TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation. J Biol Chem 278:36005-36012
22. Daoud S, Schinzel R, Neumann A, et al. (2001) Advanced glycation end products: activators of cardiac remodeling in primary fibroblasts from adult rat hearts. Mol Med 7:543-551
23. Chuang YY, Tran NL, Rusk N, et al. (2004) Role of synaptojanin 2 in glioma cell migration and invasion. Cancer Res 64:8271-8275
24. Girgenrath M, Weng S, Kostek CA, et al. (2006) TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration. EMBO J 25:5826-5839
25. Sanz AB, Sanchez-Nino MD, Izquierdo MC, et al. (2009) Tweak induces proliferation in renal tubular epithelium: a role in uninephrectomy induced renal hyperplasia. J Cell Mol Med 13:3329-3342
26. Novoyatleva T, Diehl F, van Amerongen MJ, et al. (2010) TWEAK is a positive regulator of cardiomyocyte proliferation. Cardiovasc Res 85:681-690
27. Jakubowski A, Ambrose C, Parr M, et al. (2005) TWEAK induces liver progenitor cell proliferation. J Clin Invest 115:2330-2340
28. Vince JE, Chau D, Callus B, et al. (2008) TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNF-alpha. J Cell Biol 182:171-184
29. Tran NL, McDonough WS, Savitch BA, et al. (2005) The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NF-kappaB pathway activation and BCL-XL/BCL-W expression. J Biol Chem 280:3483-3492
30. Min KJ, Lee JT, Joe EH, et al. (2011) An IkappaBalpha phosphorylation inhibitor induces heme oxygenase-1 (HO-1) expression through the activation of reactive oxygen species (ROS)-Nrf2-ARE signaling and ROS-PI3 K/Akt signaling in an NF-kappaB-independent mechanism. Cell Signal 23:1505-1513
31. Li YY, McTiernan CF, Feldman AM (2000) Interplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodeling. Cardiovasc Res 46:214-224
32. Li YY, Kadokami T, Wang P, et al. (2002) MMP inhibition modulates TNF-alpha transgenic mouse phenotype early in the development of heart failure. Am J Physiol Heart Circ Physiol 282:H983-H989
33. Bauters C, Lamblin N, Mc Fadden EP, et al. (2003) Influence of diabetes mellitus on heart failure risk and outcome. Cardiovasc Diabetol 2:1
34. Krenning G, Zeisberg EM, Kalluri R (2010) The origin of fibroblasts and mechanism of cardiac fibrosis. J Cell Physiol 225:631-637
35. Brown RD, Ambler SK, Mitchell MD, et al. (2005) The cardiac fibroblast: therapeutic target in myocardial remodeling and failure. Annu Rev Pharmacol Toxicol 45:657-687
36. Sun Y, Kiani MF, Postlethwaite AE, et al. (2002) Infarct scar as living tissue. Basic Res Cardiol 97:343-347
37. Zlokovic BV (2006) Remodeling after stroke. Nat Med 12:390-391
38. Chaturvedi RR, Herron T, Simmons R, et al. (2010) Passive stiffness of myocardium from congenital heart disease and implications for diastole. Circulation 121:979-988
39. Bover LC, Cardo-Vila M, Kuniyasu A, et al. (2007) A previously unrecognized protein-protein interaction between TWEAK and CD163: potential biological implications. J Immunol 178:8183-8194
40. Dogra C, Hall SL, Wedhas N, et al. (2007) Fibroblast growth factor-inducible 14 (Fn14) is required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes. Evidence for TWEAK-independent functions of Fn14 during myogenesis. J Biol Chem 282:15000-15010
41. Chorianopoulos E, Heger T, Lutz M, et al. (2010) FGF-inducible 14-kDa protein (Fn14) is regulated via the RhoA/ROCK kinase pathway in cardiomyocytes and mediates nuclear factor-kappaB activation by TWEAK. Basic Res Cardiol 105:301-313
42. Dogra C, Changotra H, Mohan S, et al. (2006) Tumor necrosis factor-like weak inducer of apoptosis inhibits skeletal myogenesis through sustained activation of nuclear factor-kappaB and degradation of MyoD protein. J Biol Chem 281:10327-10336
43. Li H, Malhotra S, Kumar A (2008) Nuclear factor-kappa B signaling in skeletal muscle atrophy. J Mol Med (Berl) 86:1113-1126
44. Hayden MS, Ghosh S (2004) Signaling to NF-kappaB. Genes Dev 18:2195-2224
45. Cuenca J, Goren N, Prieto P, et al. (2007) Selective impairment of nuclear factor-kappaB-dependent gene transcription in adult cardiomyocytes: relevance for the regulation of the inflammatory response in the heart. Am J Pathol 171:820-828
46. Yang M, Wu J, Martin CM, et al. (2008) Important role of p38 MAP kinase/NF-kappaB signaling pathway in the sepsis-induced conversion of cardiac myocytes to a proinflammatory phenotype. Am J Physiol Heart Circ Physiol 294:H994-H1001
47. Yepes M (2007) TWEAK and the central nervous system. Mol Neurobiol 35:255-265
48. Potrovita I, Zhang W, Burkly L, et al. (2004) Tumor necrosis factor-like weak inducer of apoptosis-induced neurodegeneration. J Neurosci 24:8237-8244
49. Li H, Mittal A, Paul PK, et al. (2009) Tumor necrosis factor-related weak inducer of apoptosis augments matrix metalloproteinase 9 (MMP-9) production in skeletal muscle through the activation of nuclear factor-kappaB-inducing kinase and p38 mitogen-activated protein kinase: a potential role of MMP-9 in myopathy. J Biol Chem 284:4439-4450
50. Awad AE, Kandalam V, Chakrabarti S, et al. (2010) Tumor necrosis factor induces matrix metalloproteinases in cardiomyocytes and cardiofibroblasts differentially via superoxide production in a PI3Kgamma-dependent manner. Am J Physiol Cell Physiol 298:C679-C692
51. Han YP, Tuan TL, Wu H, et al. (2001) TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-kappaB mediated induction of MT1-MMP. J Cell Sci 114:131-139
52. Meiners S, Hocher B, Weller A, et al. (2004) Downregulation of matrix metalloproteinases and collagens and suppression of cardiac fibrosis by inhibition of the proteasome. Hypertension 44:471-477
53. Xia L, Shen H, Lu J, et al. (2011) TRAF2 and cIAP2 involve in TWEAK-induced MMP-9 production in fibroblast-like synoviocytes. Rheumatol Int 32:281-282
54. Polavarapu R, Gongora MC, Winkles JA, et al. (2005) Tumor necrosis factor-like weak inducer of apoptosis increases the permeability of the neurovascular unit through nuclear factor-kappa B pathway activation. J Neurosci 25:10094-10100