Plant natural products: From traditional compounds to new emerging drugs in cancer therapy

Cell Proliferation

Volumn 47, Issue 6, 2014, Pages 506-515

  Ouyang, L ^a   Luo, Y ^b   Tian, M ^a   Zhang, S Y ^a   Lu, R ^c   Wang, J H ^d   Kasimu, R ^d   Li, X ^a  

^a SICHUAN UNIVERSITY   (China)

^b Shenyang Yaoda Pharmaceutical Co Ltd   (China)

^c SICHUAN UNIVERSITY   (China)

^d XINJIANG MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSAICIN; CURCUMIN; NATURAL PRODUCT; PLANT EXTRACT; RESVERATROL; ANTINEOPLASTIC AGENT; BIOLOGICAL PRODUCT;

ANTINEOPLASTIC ACTIVITY; CANCER THERAPY; HUMAN; PANCREAS CANCER; PLANT PRODUCT; REVIEW; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; FEMALE; METABOLISM; NEOPLASMS; PLANT; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOLOGICAL PRODUCTS; CELL SURVIVAL; FEMALE; HUMANS; NEOPLASMS; PLANT EXTRACTS; PLANTS; SIGNAL TRANSDUCTION;

EID: 84911951862     PISSN: 09607722     EISSN: 13652184     Source Type: Journal    
DOI: 10.1111/cpr.12143     Document Type: Review

References (81)

1. Cirla A, Mann J (2003) Combretastatins, from natural products to drug discovery. Nat. Prod. Rep. 20, 558-564.
2. Canel C, Moraes RM, Dayan FE, Ferreira D (2000) Podophyllotoxin. Phytochemistry 54, 115-120.
3. Clardy J, Walsh C (2004) Lessons from natural molecules. Nature 432, 829-837.
4. Balunas MJ, Kinghorn AD (2005) Drug discovery from medicinal plants. Life Sci. 78, 431-441.
5. Liu B, Min MW, Bao JK (2009) Induction of apoptosis by Concanavalin A and its molecular mechanisms in cancer cells. Autophagy 5, 432-433.
6. Radhika NK, Sreejith P, Asha V (2010) Cytotoxic and apoptotic activity of Cheilanthes farinosa (Forsk.) Kaulf. against human hepatoma, Hep3B cells. J. Ethnopharmacol. 128, 166-171.
7. Glienke W, Maute L, Wicht J, Bergmann L (2009) Curcumin inhibits constitutive STAT3 phosphorylation in human pancreatic cancer cell lines and down regulation of survivin/BIRC5 gene expression. Cancer Invest. 28, 166-171.
8. Sahu R, Batra S, Srivastava S (2009) Activation of ATM/Chk1 by Curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells. Br. J. Cancer 100, 1425-1433.
9. Hidaka H, Ishiko T, Furuhashi T, Kamohara H, Suzuki S, Miyazaki M, et al. (2002) Curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface. Cancer 95, 1206-1214.
10. Hutzen B, Friedman L, Sobo M, Lin L, Cen L, De Angelis S, et al. (2009) Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas. Int. J. Oncol. 35, 867-872.
11. Yang CS, Wang X (2010) Green tea and cancer prevention. Nutr. Cancer 62, 931-937.
12. Pramanik KC, Srivastava SK (2012) Apoptosis signal-regulating kinase 1-thioredoxin complex dissociation by capsaicin causes pancreatic tumor growth suppression by inducing apoptosis. Antioxid. Redox Signal. 17, 1417-1432.
13. Zhang L, Pang E, Loo RRO, Rao J, Go VLW, Loo JA, et al. (2011) Concomitant inhibition of HSP90, its mitochondrial localized homologue TRAP1 and HSP27 by green tea in pancreatic cancer HPAF-II cells. Proteomics 11, 4638-4647.
14. Qanungo S, Das M, Haldar S, Basu A (2005) Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells. Carcinogenesis 26, 958-967.
15. Hariharan D, Saied A, Kocher HM (2008) Analysis of mortality rates for pancreatic cancer across the world. HPB 10, 58-62. doi:10.1080/13651820701883148.
16. Tang SN, Fu J, Nall D, Rodova M, Shankar S, Srivastava RK (2012) Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics. Int. J. Cancer 131, 30-40.
17. Shankar S, Suthakar G, Srivastava RK (2007) Epigallocatechin-3-gallate inhibits cell cycle and induces apoptosis in pancreatic cancer. Front. Biosci. 12, 5039-5051.
18. Sun W, Wang W, Kim J, Keng P, Yang S, Zhang H, et al. (2008) Anti-cancer effect of resveratrol is associated with induction of apoptosis via a mitochondrial pathway alignment. Adv. Exp. Med. Biol. 614, 179-186.
19. Mo W, Xu X, Xu L, Wang F, Ke A, Wang X, et al. (2011) Resveratrol inhibits proliferation and induces apoptosis through the hedgehog signaling pathway in pancreatic cancer cell. Pancreatology. 11, 601-609.
20. Roy SK, Chen Q, Fu J, Shankar S, Srivastava RK (2011) Resveratrol inhibits growth of orthotopic pancreatic tumors through activation of FOXO transcription factors. PLoS One 6, e25166.
21. Chen Q, Ganapathy S, Singh KP, Shankar S, Srivastava RK (2010) Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells. PLoS One 5, e15288.
22. Divya CS, Pillai MR (2006) Antitumor action of Curcumin in human papillomavirus associated cells involves downregulation of viral oncogenes, prevention of NFkB and AP-1 translocation, and modulation of apoptosis. Mol. Carcinog. 45, 320-332.
23. Prusty BK, Das BC (2005) Constitutive activation of transcription factor AP-1 in cervical cancer and suppression of human papillomavirus (HPV) transcription and AP-1 activity in HeLa cells by Curcumin. Int. J. Cancer 113, 951-960.
24. Singh M, Singh N (2011) Curcumin counteracts the proliferative effect of estradiol and induces apoptosis in cervical cancer cells. Mol. Cell. Biochem. 347, 1-11.
25. Javvadi P, Segan AT, Tuttle SW, Koumenis C (2008) The chemopreventive agent Curcumin is a potent radiosensitizer of human cervical tumor cells via increased reactive oxygen species production and overactivation of the mitogen-activated protein kinase pathway. Mol. Pharmacol. 73, 1491-1501.
26. Sreekanth C, Bava S, Sreekumar E, Anto R (2011) Molecular evidences for the chemosensitizing efficacy of liposomal curcumin in paclitaxel chemotherapy in mouse models of cervical cancer. Oncogene 30, 3139-3152.
27. Zoberi I, Bradbury CM, Curry HA, Bisht KS, Goswami PC, Roti Roti JL, et al. (2002) Radiosensitizing and anti-proliferative effects of resveratrol in two human cervical tumor cell lines. Cancer Lett. 175, 165-173.
28. Kramer MP, Wesierska-Gadek J (2009) Monitoring of long-term effects of resveratrol on cell cycle progression of human HeLa cells after administration of a single dose. Ann. N. Y. Acad. Sci. 1171, 257-263.
29. Woo J-H, Lim JH, Kim Y-H, Suh S-I, Min DS, Chang J-S, et al. (2003) Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC δ signal transduction. Oncogene 23, 1845-1853.
30. Hsu K-F, Wu C-L, Huang S-C, Wu C-M, Hsiao J-R, Yo Y-T, et al. (2009) Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells. Autophagy 5, 451-460.
31. Liu B, Cheng Y, Bian H-J, Bao J-K (2009) Molecular mechanisms of Polygonatum cyrtonema lectin induced apoptosis and autophagy in cancer cells. Autophagy 5, 253-255.
32. Chodon D, Ramamurty N, Sakthisekaran D (2007) Preliminary studies on induction of apoptosis by genistein on HepG2 cell line. Toxicol. In Vitro 21, 887-891.
33. Osborne CK, Yochmowitz MG, Knight WA, McGuire WL (1980) The value of estrogen and progesterone receptors in the treatment of breast cancer. Cancer 46, 2884-2888.
34. Pavese JM, Farmer RL, Bergan RC (2010) Inhibition of cancer cell invasion and metastasis by genistein. Cancer Metastasis Rev. 29, 465-482.
35. Li Y, Bhuiyan M, Sarkar F (1999) Induction of apoptosis and inhibition of c-erbB-2 in MDA-MB-435 cells by genistein. Int. J. Oncol. 15, 525-558.
36. DeSantis C, Siegel R, Bandi P, Jemal A (2011) Breast cancer statistics. CA Cancer J. Clin. 61, 409-418.
37. Findlay M, Von Minckwitz G, Wardley A (2008) Effective oral chemotherapy for breast cancer, pillars of strength. Ann. Oncol. 19, 212-222.
38. Cornwell T, Cohick W, Raskin I (2004) Dietary phytoestrogens and health. Phytochemistry 65, 995-1016.
39. +)-mediated apoptosis in breast cancer cells. Life Sci. 80, 245-253.
40. Abhyankar G, Suprasanna P, Pandey B, Mishra K, Rao K, Reddy V (2010) Hairy root extract of Phyllanthus amarus induces apoptotic cell death in human breast cancer cells. Innov. Food Sci. Emerg. 11, 526-532.
41. Russo M, Spagnuolo C, Tedesco I, Bilotto S, Russo GL (2012) The flavonoid quercetin in disease prevention and therapy, facts and fancies. Biochem. Pharmacol. 83, 6-15.
42. Sharma RA, McLelland HR, Hill KA, Ireson CR, Euden SA, Manson MM, et al. (2001) Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clin. Cancer Res. 7, 1894-1900.
43. Buys SS, Partridge E, Greene MH, Prorok PC, Reding D, Riley TL, et al. (2005) Ovarian cancer screening in the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial, findings from the initial screen of a randomized trial. Am. J. Obstet. Gynecol. 193, 1630-1639.
44. Yu Y, Hamza A, Zhang T, Gu M, Zou P, Newman B, et al. (2010) Withaferin A targets heat shock protein 90 in pancreatic cancer cells. Biochem. Pharmacol. 79, 542-551.
45. Zhang X, Samadi AK, Roby KF, Timmermann B, Cohen MS (2012) Inhibition of cell growth and induction of apoptosis in ovarian carcinoma cell lines CaOV3 and SKOV3 by natural withanolide Withaferin A. Gynecol. Oncol. 124, 606-612.
46. Kuribara H, Stavinoha WB, Maruyama Y (1998) Behavioural pharmacological characteristics of honokiol, an anxiolytic agent present in extracts of Magnolia bark, evaluated by an elevated plus-maze test in mice. J. Pharm. Pharmacol. 50, 819-826.
47. Li Z, Liu Y, Zhao X, Pan X, Yin R, Huang C, et al. (2008) Honokiol, a natural therapeutic candidate, induces apoptosis and inhibits angiogenesis of ovarian tumor cells. Eur. J. Obstet. Gynecol. Reprod. Biol. 140, 95-102.
48. Yang C-J, Huang Y-J, Wang C-Y, Wang C-S, Wang P-H, Hung J-Y, et al. (2010) Antiproliferative and antitumorigenic activity of Toona sinensis leaf extracts in lung adenocarcinoma. J. Med. Food 13, 54-61.
49. Lin Y-W, Yang F-J, Chen C-L, Lee W-T, Chen R-S (2010) Free radical scavenging activity and antiproliferative potential of Polygonum cuspidatum root extracts. J. Nat. Med. 64, 146-152.
50. Lee DH, Szczepanski MJ, Lee YJ (2009) Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells. J. Cell. Biochem. 106, 1113-1122.
51. Sinha S, Pal BC, Jagadeesh S, Banerjee PP, Bandyopadhaya A, Bhattacharya S (2006) Mahanine inhibits growth and induces apoptosis in prostate cancer cells through the deactivation of Akt and activation of caspases. Prostate 66, 1257-1265.
52. Estrada AC, Syrovets T, Pitterle K, Lunov O, Büchele B, Schimana-Pfeifer J, et al. (2010) Tirucallic acids are novel pleckstrin homology domain-dependent Akt inhibitors inducing apoptosis in prostate cancer cells. Mol. Pharmacol. 77, 378-387.
53. Fu L-L, Zhou C-C, Yao S, Yu J-Y, Liu B, Bao J-K (2011) Plant lectins: targeting programmed cell death pathways as anti-tumor agents. Int. J. Biochem. Cell Biol. 43, 1442-1449.
54. Prasad KN, Hao J, Yi C, Zhang D, Qiu S, Jiang Y, et al. (2009) Antioxidant and anticancer activities of wampee (Clausena lansium (Lour.) Skeels) peel. J. Biomed. Biotechnol. 2009, 612805.
55. Xue X, Sun D-F, Sun C-C, Liu H-P, Yue B, Zhao C-R, et al. (2012) Inhibitory effect of riccardin D on growth of human non-small cell lung cancer: in vitro and in vivo studies. Lung Cancer 76, 300-308.
56. Siegel R, Naishadham D, Jemal A (2012) Cancer statistics. CA Cancer J. Clin. 62, 10-29.
57. Gonçalves P, Araújo JR, Pinho MJ, Martel F (2011) In vitro studies on the inhibition of colon cancer by butyrate and polyphenolic compounds. Nutr. Cancer 63, 282-294.
58. Kim WK, Bang MH, Kim ES, Kang NE, Jung KC, et al. (2005) Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells. J. Nutr. Biochem. 16, 155-162.
59. Psahoulia FH, Moumtzi S, Roberts ML, Sasazuki T, Shirasawa S, Pintzas A (2007) Quercetin mediates preferential degradation of oncogenic Ras and causes autophagy in Ha-RAS-transformed human colon cells. Carcinogenesis 28, 1021-1031.
60. Mertens-Talcott SU, Percival SS (2005) Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells. Cancer Lett. 218, 141-151.
61. Gee JM, Hara H, Johnson IT (2002) Suppression of intestinal crypt cell proliferation and aberrant crypt foci by dietary quercetin in rats. Nutr. Cancer 43, 193-201.
62. Johnson IT (2007) Phytochemicals and cancer. Proc. Nutr. Soc. 66, 207-215.
63. Nair HK, Rao KV, Aalinkeel R, Mahajan S, Chawda R, Schwartz SA (2004) Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin. Diagn. Lab. Immunol. 11, 63-69.
64. Athar M, Back JH, Kopelovich L, Bickers DR, Kim AL (2009) Multiple molecular targets of resveratrol, anti-carcinogenic mechanisms. Arch. Biochem. Biophys. 486, 95-102.
65. Joe AK, Liu H, Suzui M, Vural ME, Xiao D, Weinstein IB (2002) Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines. Clin. Cancer Res. 8, 893-903.
66. Juan MEl, Wenzel U, Daniel H, Planas JM (2008) Resveratrol induces apoptosis through ROS-dependent mitochondria pathway in HT-29 human colorectal carcinoma cells. J. Agric. Food Chem. 56, 4813-4818.
67. Prasanna R, Chinnakonda Chandramoorthy H, Ramaiyapillai P, Sakthisekaran D (2011) In vitro evaluation of anticancer effect of Cassia auriculata leaf extract and Curcumin through induction of apoptosis in human breast and larynx cancer cell lines. Biomed. Prevent. Nutr. 1, 153-160.
68. Shih Y-H, Chang K-W, Hsia S-M, Yu C-C, Fuh L-J, Chi T-Y, et al. (2013) In vitro antimicrobial and anticancer potential of hinokitiol against oral pathogens and oral cancer cell lines. Microbiol. Res. 12, 254-262.
69. Liu S, Yamauchi H (2006) Hinokitiol, a metal chelator derived from natural plants, suppresses cell growth and disrupts androgen receptor signaling in prostate carcinoma cell lines. Biochem. Biophys. Res. Commun. 351, 26-32.
70. Yen C-Y, Chiu C-C, Haung R-W, Yeh C-C, Huang K-J, Chang K-F, et al. (2012) Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction. Mutat. Res. 747, 253-258.
71. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J. Clin. 61, 69-90.
72. Li Y, Martin RC (2011) Herbal medicine and hepatocellular carcinoma, applications and challenges. Evid. Based Complement. Alternat. Med. 2011, 541209.
73. Brückner M, Westphal S, Domschke W, Kucharzik T, Lügering A (2012) Green tea polyphenol epigallocatechin-3-gallate shows therapeutic antioxidative effects in a murine model of colitis. J. Crohns Colitis. 6, 226-235.
74. Hanahan D, Weinberg RA (2011) Hallmarks of cancer, the next generation. Cell 144, 646-674.
75. Napoleone E, Zurlo F, Latella MC, Amore C, Di Santo A, et al. (2009) Paclitaxel down-regulates tissue factor in cancer and host tumour-associated cells. Eur. J. Cancer 45, 470-477.
76. Ren W, Tang DG (1999) Extract of Solanum muricatum (Pepino/CSG) inhibits tumor growth by inducing apoptosis. Anticancer Res. 19, 403-408.
77. Bueno CA, Lombardi MG, Sales ME, Alché LE (2012) A natural antiviral and immunomodulatory compound with antiangiogenic properties. Microvasc. Res. 84, 235-241.
78. Prabhu VV1, Guruvayoorappan C (2013) Inhibition of metastatic lung cancer in C57BL/6 mice by marine mangrove Rhizophora apiculata. Asian Pac. J. Cancer Prev. 14, 1833-1840.
79. Boligon AA, Sagrillo MR, Machado LF, de Souza Filho O, Machado MM, da Cruz IB et al. (2012) Protective effects of extracts and flavonoids isolated from Scutia buxifolia Reissek against chromosome damage in human lymphocytes exposed to hydrogen peroxide. Molecules 17, 5757-5769.
80. Armstrong EP (2010) Prophylaxis of cervical cancer and related cervical disease: a review of the cost-effectiveness of vaccination against oncogenic HPV types. J. Managed Care Phar. 16, 217-230.
81. Yu J, Ma Y, Drisko J, Chen Q (2013) Antitumor activities of rauwolfia vomitoria extract and potentiation of carboplatin effects against ovarian cancer. Curr. Ther. Res. Clin. Exp. 75, 8-14. doi:10.1016/j.curtheres.2013.04.001.