Extract of Solanum muricatum (Pepino/CSG) inhibits tumor growth by inducing apoptosis

Anticancer Research

Volumn 19, Issue 1 A, 1999, Pages 403-408

  Ren, Weiping ^a,b,e   Tang, Dean G ^c,d  

^a Virotech Canada Inc   (Canada)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c WAYNE STATE UNIVERSITY   (United States)

^d KARMANOS CANCER INSTITUTE   (United States)

^e NONE   (Canada)

Author keywords

Apoptosis; Chemoprevention; Solanum muricatum

Indexed keywords

ANTINEOPLASTIC AGENT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PLANT EXTRACT; SOLANUM ALKALOID; TRYPAN BLUE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL SURVIVAL; COLON CANCER; ENDOTHELIUM CELL; GROWTH INHIBITION; LD 50; LIVER CANCER; LUNG CANCER; LUNG FIBROBLAST; MICROSCOPY; NUDE MOUSE; OVARY CANCER; PRIORITY JOURNAL; PROSTATE CANCER; STOMACH CANCER; TUMOR GROWTH; TUMOR VOLUME; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

ANIMALS; ANTICARCINOGENIC AGENTS; APOPTOSIS; HUMANS; LIVER NEOPLASMS; MALE; MICE; MICE, NUDE; PLANT EXTRACTS; PLANTS, MEDICINAL; PROSTATIC NEOPLASMS; STOMACH NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 0032897452     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Morley-Bunker MJS: A new commercial crop, the Pepino (Solanum muricatum AIT) and suggestions for further development. Annual J Royal New Zealand Inst of Hort 11: 8-19, 1983.
2. Prohans J, Ruiz JJ, Nuez F: The Pepino (Solanum muricatum, Solanaceae): A "new" crop with a history. Economics Botany 50: 355-368, 1996.
3. Unnikrishnan MC and Kuttan R: Tumor reducing and anticarcinogenic activity of selected spices. Cancer Lett 51: 85-89, 1990.
4. Goodpasture CE and Arrighi FE: Effects of food seasoning on the cell cycle and chromosome morphology of mammalian cells in vitro with special reference to turmeric. Food Cosmet Toxicol 14: 9-14, 1976.
5. Mohanan PV and Devi KS: Cytotoxic potential of the preparation from Solarium trilobatum and the effect of sobatum on tumor reduction in mice. Cancer Lett 110: 71-76, 1996.
6. Hsu SH, Tsai TR, Lin CN, Yen MH and Kuo KW: Solamargine purified from Solanum incanum Chinese Herb Triggers Gene Expression of Human TNFR I which may lead to cell apoptosis. Biochem Biophys Res Com 229: 1-5, 1996.
7. Chiang HC, Tseng TH, Wang CJ, Chen CF and Kan WS: Experimental antitumor agents from Solanum indicum L. Anticancer Res 11: 1911-1918, 1991.
8. Mohanan FV and Devi KS: Effect of Sobatum on tumor development and chemically induced carcinogenesis. Cancer Lett 112: 219-223, 1997.
9. Kerr JF, Wyllie AH and Currie AR: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26: 239-257, 1972.
10. Wyllie AH, Kerr JF and Currie AR: Cell death: the significance of apoptosis. Int Rev Cytol 68: 251-306, 1980.
11. Buja LM, Eigenbrodt ML, Eigenbrodt EH: Apoptosis and necrosis: Basic types and mechanisms of cell death. Arch Pathol Lab Med 117: 1208-1214, 1993.
12. Hickman JA: Apoptosis induced by anticancer drugs. Cancer Metastasis Rev 11: 121-139, 1992.
13. Tang DG, Porter AT: Target to apoptosis: A hopeful weapon for prostate cancer. Prostate 32: 284-293, 1997.
14. Tang DG, Li L, Chopra D, and Porter AT: Extended survivability of prostate cancer cells in the absence of trophic factors: Increased proliferation, evasion of apoptosis and the role of apoptosis proteins. Cancer Res 58: 3466-3479, 1998.
15. Tang DG, Honn KV: Apoptosis of W256 carcinosarcoma cells of the monocytoid origin induced by NDGA involves lipid peroxidation and depletion of GSH: Role of 12-lipoxygenase in regulating tumor cell survival. J Cell Physiol 172: 155-170, 1997.
16. Tang DG, Guan KL, Li L, Honn KV, Chen YQ, Rice RL, Taylor JD and Porter AT: Suppression of W256 carcinosarcoma cell apoptosis by arachidonic acid and other unsaturated fatty acids. Int J Cancer 72: 1078-1087, 1997.
17. Tang DG, Li L, Zhu Z, and Joshi B: Apoptosis in the absence of cytochrome c accumulation in the cytosol. Biochem Biophys Res Commun 242: 380-384, 1998.