-
1
-
-
0035978751
-
ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology
-
Perraud AL, Fleig A, Dunn CA, Bagley LA, Launay P, et al. (2001) ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature 411: 595-599.
-
(2001)
Nature
, vol.411
, pp. 595-599
-
-
Perraud, A.L.1
Fleig, A.2
Dunn, C.A.3
Bagley, L.A.4
Launay, P.5
-
2
-
-
38449104252
-
Transient receptor potential (TRP) cation channels: Rewarding unique proteins
-
Nilius B (2007) Transient receptor potential (TRP) cation channels: rewarding unique proteins. Bull Mem Acad R Med Belg 162: 244-253.
-
(2007)
Bull Mem Acad R Med Belg
, vol.162
, pp. 244-253
-
-
Nilius, B.1
-
3
-
-
77956272001
-
International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family
-
Wu LJ, Sweet TB, Clapham DE (2010) International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev 62: 381-404.
-
(2010)
Pharmacol Rev
, vol.62
, pp. 381-404
-
-
Wu, L.J.1
Sweet, T.B.2
Clapham, D.E.3
-
4
-
-
33751107228
-
Conserved cysteine residues in the pore region are obligatory for human TRPM2 channel function
-
Mei ZZ, Mao HJ, Jiang LH (2006) Conserved cysteine residues in the pore region are obligatory for human TRPM2 channel function. Am J Physiol Cell Physiol 291: C1022-1028.
-
(2006)
Am J Physiol Cell Physiol
, vol.291
, pp. C1022-C1028
-
-
Mei, Z.Z.1
Mao, H.J.2
Jiang, L.H.3
-
5
-
-
77955463362
-
TRPM2 channel properties, functions and therapeutic potentials
-
Jiang LH, Yang W, Zou J, Beech DJ (2010) TRPM2 channel properties, functions and therapeutic potentials. Expert Opin Ther Targets 14: 973-988.
-
(2010)
Expert Opin Ther Targets
, vol.14
, pp. 973-988
-
-
Jiang, L.H.1
Yang, W.2
Zou, J.3
Beech, D.J.4
-
6
-
-
0035902767
-
Immunocyte Ca2+ influx system mediated by LTRPC2
-
Sano Y, Inamura K, Miyake A, Mochizuki S, Yokoi H, et al. (2001) Immunocyte Ca2+ influx system mediated by LTRPC2. Science 293: 1327-1330.
-
(2001)
Science
, vol.293
, pp. 1327-1330
-
-
Sano, Y.1
Inamura, K.2
Miyake, A.3
Mochizuki, S.4
Yokoi, H.5
-
7
-
-
0038237529
-
Critical intracellular Ca2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation
-
McHugh D, Flemming R, Xu SZ, Perraud AL, Beech DJ (2003) Critical intracellular Ca2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation. J Biol Chem 278: 11002-11006.
-
(2003)
J Biol Chem
, vol.278
, pp. 11002-11006
-
-
McHugh, D.1
Flemming, R.2
Xu, S.Z.3
Perraud, A.L.4
Beech, D.J.5
-
8
-
-
62349105171
-
Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate
-
Csanady L, Torocsik B (2009) Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate. J Gen Physiol 133: 189-203.
-
(2009)
J Gen Physiol
, vol.133
, pp. 189-203
-
-
Csanady, L.1
Torocsik, B.2
-
9
-
-
73149103711
-
Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity
-
Du J, Xie J, Yue L (2009) Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity. J Gen Physiol 134: 471-488.
-
(2009)
J Gen Physiol
, vol.134
, pp. 471-488
-
-
Du, J.1
Xie, J.2
Yue, L.3
-
10
-
-
79953153188
-
TRPM2: A multifunctional ion channel for calcium signalling
-
Sumoza-Toledo A, Penner R (2011) TRPM2: a multifunctional ion channel for calcium signalling. J Physiol 589: 1515-1525.
-
(2011)
J Physiol
, vol.589
, pp. 1515-1525
-
-
Sumoza-Toledo, A.1
Penner, R.2
-
11
-
-
83855165656
-
The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation
-
Di A, Gao XP, Qian F, Kawamura T, Han J, et al. (2012) The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation. Nat Immunol 13: 29-34.
-
(2012)
Nat Immunol
, vol.13
, pp. 29-34
-
-
Di, A.1
Gao, X.P.2
Qian, F.3
Kawamura, T.4
Han, J.5
-
12
-
-
84858027505
-
TRPM2 contributes to inflammatory and neuropathic pain through the aggravation of pronociceptive inflammatory responses in mice
-
Haraguchi K, Kawamoto A, Isami K, Maeda S, Kusano A, et al. (2012) TRPM2 contributes to inflammatory and neuropathic pain through the aggravation of pronociceptive inflammatory responses in mice. J Neurosci 32: 3931-3941.
-
(2012)
J Neurosci
, vol.32
, pp. 3931-3941
-
-
Haraguchi, K.1
Kawamoto, A.2
Isami, K.3
Maeda, S.4
Kusano, A.5
-
13
-
-
33846402429
-
TRPM channels, calcium and redox sensors during innate immune responses
-
Massullo P, Sumoza-Toledo A, Bhagat H, Partida-Sanchez S (2006) TRPM channels, calcium and redox sensors during innate immune responses. Semin Cell Dev Biol 17: 654-666.
-
(2006)
Semin Cell Dev Biol
, vol.17
, pp. 654-666
-
-
Massullo, P.1
Sumoza-Toledo, A.2
Bhagat, H.3
Partida-Sanchez, S.4
-
14
-
-
79960086411
-
TRPM2 modulates insulin secretion in pancreatic beta-cells
-
Uchida K, Tominaga M (2011) TRPM2 modulates insulin secretion in pancreatic beta-cells. Islets 3: 209-211.
-
(2011)
Islets
, vol.3
, pp. 209-211
-
-
Uchida, K.1
Tominaga, M.2
-
15
-
-
55549140796
-
Identification of novel sense and antisense transcription at the TRPM2 locus in cancer
-
Orfanelli U, Wenke AK, Doglioni C, Russo V, Bosserhoff AK, et al. (2008) Identification of novel sense and antisense transcription at the TRPM2 locus in cancer. Cell Res 18: 1128-1140.
-
(2008)
Cell Res
, vol.18
, pp. 1128-1140
-
-
Orfanelli, U.1
Wenke, A.K.2
Doglioni, C.3
Russo, V.4
Bosserhoff, A.K.5
-
16
-
-
77957270790
-
State-dependent inhibition of TRPM2 channel by acidic pH
-
Yang W, Zou J, Xia R, Vaal ML, Seymour VA, et al. (2010) State-dependent inhibition of TRPM2 channel by acidic pH. J Biol Chem 285: 30411-30418.
-
(2010)
J Biol Chem
, vol.285
, pp. 30411-30418
-
-
Yang, W.1
Zou, J.2
Xia, R.3
Vaal, M.L.4
Seymour, V.A.5
-
17
-
-
79959873314
-
Zinc inactivates melastatin transient receptor potential 2 channels via the outer pore
-
Yang W, Manna PT, Zou J, Luo J, Beech DJ, et al. (2011) Zinc inactivates melastatin transient receptor potential 2 channels via the outer pore. J Biol Chem 286: 23789-23798.
-
(2011)
J Biol Chem
, vol.286
, pp. 23789-23798
-
-
Yang, W.1
Manna, P.T.2
Zou, J.3
Luo, J.4
Beech, D.J.5
-
18
-
-
56649103766
-
Altered functional properties of a TRPM2 variant in Guamanian ALS and PD
-
Hermosura MC, Cui AM, Go RC, Davenport B, Shetler CM, et al. (2008) Altered functional properties of a TRPM2 variant in Guamanian ALS and PD. Proc Natl Acad Sci U S A 105: 18029-18034.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 18029-18034
-
-
Hermosura, M.C.1
Cui, A.M.2
Go, R.C.3
Davenport, B.4
Shetler, C.M.5
-
19
-
-
84865190336
-
Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents
-
Toth B, Csanady L (2012) Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents. Proc Natl Acad Sci U S A 109: 13440-13445.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 13440-13445
-
-
Toth, B.1
Csanady, L.2
-
20
-
-
84919673185
-
Copper mediated neurological disorder: Visions into amyotrophic lateral sclerosis, Alzheimer and Menkes disease
-
Ahuja A, Dev K, Tanwar RS, Selwal KK, Tyagi PK (2014) Copper mediated neurological disorder: Visions into amyotrophic lateral sclerosis, Alzheimer and Menkes disease. J Trace Elem Med Biol.
-
(2014)
J Trace Elem Med Biol
-
-
Ahuja, A.1
Dev, K.2
Tanwar, R.S.3
Selwal, K.K.4
Tyagi, P.K.5
-
21
-
-
84878398353
-
Basic fibroblast growth factor attenuates bisphosphonate-induced oxidative injury but decreases zinc and copper levels in oral epithelium of rat
-
Kocer G, Naziroglu M, Celik O, Onal L, Ozcelik D, et al. (2013) Basic fibroblast growth factor attenuates bisphosphonate-induced oxidative injury but decreases zinc and copper levels in oral epithelium of rat. Biol Trace Elem Res 153: 251-256.
-
(2013)
Biol Trace Elem Res
, vol.153
, pp. 251-256
-
-
Kocer, G.1
Naziroglu, M.2
Celik, O.3
Onal, L.4
Ozcelik, D.5
-
22
-
-
0027376466
-
Cloning the Wilson disease gene
-
Chelly J, Monaco AP (1993) Cloning the Wilson disease gene. Nat Genet 5: 317-318.
-
(1993)
Nat Genet
, vol.5
, pp. 317-318
-
-
Chelly, J.1
Monaco, A.P.2
-
23
-
-
34548181105
-
An epidemiological study of reproductive function biomarkers in male welders
-
Ellingsen DG, Chashchin V, Haug E, Chashchin M, Tkachenko V, et al. (2007) An epidemiological study of reproductive function biomarkers in male welders. Biomarkers 12: 497-509.
-
(2007)
Biomarkers
, vol.12
, pp. 497-509
-
-
Ellingsen, D.G.1
Chashchin, V.2
Haug, E.3
Chashchin, M.4
Tkachenko, V.5
-
24
-
-
77953841809
-
Copper in diseases and treatments, and copper-based anticancer strategies
-
Tisato F, Marzano C, Porchia M, Pellei M, Santini C (2010) Copper in diseases and treatments, and copper-based anticancer strategies. Med Res Rev 30: 708-749.
-
(2010)
Med Res Rev
, vol.30
, pp. 708-749
-
-
Tisato, F.1
Marzano, C.2
Porchia, M.3
Pellei, M.4
Santini, C.5
-
25
-
-
79959610444
-
Molecular pathogenesis of achromatopsia associated with mutations in the cone cyclic nucleotide-gated channel CNGA3 subunit
-
Ding XQ, Fitzgerald JB, Quiambao AB, Harry CS, Malykhina AP (2010) Molecular pathogenesis of achromatopsia associated with mutations in the cone cyclic nucleotide-gated channel CNGA3 subunit. Adv Exp Med Biol 664: 245-253.
-
(2010)
Adv Exp Med Biol
, vol.664
, pp. 245-253
-
-
Ding, X.Q.1
Fitzgerald, J.B.2
Quiambao, A.B.3
Harry, C.S.4
Malykhina, A.P.5
-
26
-
-
0027939974
-
Toxic effects of heavy metals on ionic channels
-
Kiss T, Osipenko ON (1994) Toxic effects of heavy metals on ionic channels. Pharmacol Rev 46: 245-267.
-
(1994)
Pharmacol Rev
, vol.46
, pp. 245-267
-
-
Kiss, T.1
Osipenko, O.N.2
-
28
-
-
84881512396
-
Copper block of extrasynaptic GABAA receptors in the mature cerebellum and striatum
-
McGee TP, Houston CM, Brickley SG (2013) Copper block of extrasynaptic GABAA receptors in the mature cerebellum and striatum. J Neurosci 33: 13431-13435.
-
(2013)
J Neurosci
, vol.33
, pp. 13431-13435
-
-
McGee, T.P.1
Houston, C.M.2
Brickley, S.G.3
-
29
-
-
77950583465
-
Heavy metals zinc, cadmium, and copper stimulate pulmonary sensory neurons via direct activation of TRPA1
-
Gu Q, Lin RL (2010) Heavy metals zinc, cadmium, and copper stimulate pulmonary sensory neurons via direct activation of TRPA1. J Appl Physiol (1985) 108: 891-897.
-
(2010)
J Appl Physiol
, vol.108
, Issue.1985
, pp. 891-897
-
-
Gu, Q.1
Lin, R.L.2
-
31
-
-
79961008694
-
External Cu2+ inhibits human epithelial Na+ channels by binding at a subunit interface of extracellular domains
-
Chen J, Myerburg MM, Passero CJ, Winarski KL, Sheng S (2011) External Cu2+ inhibits human epithelial Na+ channels by binding at a subunit interface of extracellular domains. J Biol Chem 286: 27436-27446.
-
(2011)
J Biol Chem
, vol.286
, pp. 27436-27446
-
-
Chen, J.1
Myerburg, M.M.2
Passero, C.J.3
Winarski, K.L.4
Sheng, S.5
-
32
-
-
42949165600
-
An extracellular Cu2+ binding site in the voltage sensor of BK and Shaker potassium channels
-
Ma Z, Wong KY, Horrigan FT (2008) An extracellular Cu2+ binding site in the voltage sensor of BK and Shaker potassium channels. J Gen Physiol 131: 483-502.
-
(2008)
J Gen Physiol
, vol.131
, pp. 483-502
-
-
Ma, Z.1
Wong, K.Y.2
Horrigan, F.T.3
-
33
-
-
84864292111
-
Divalent copper is a potent extracellular blocker for TRPM2 channel
-
Zeng B, Chen GL, Xu SZ (2012) Divalent copper is a potent extracellular blocker for TRPM2 channel. Biochem Biophys Res Commun 424: 279-284.
-
(2012)
Biochem Biophys Res Commun
, vol.424
, pp. 279-284
-
-
Zeng, B.1
Chen, G.L.2
Xu, S.Z.3
-
34
-
-
84877064823
-
Site-directed mutagenesis to study the structurefunction relationships of ion channels
-
Yang W, Jiang LH (2013) Site-directed mutagenesis to study the structurefunction relationships of ion channels. Methods Mol Biol 998: 257-266.
-
(2013)
Methods Mol Biol
, vol.998
, pp. 257-266
-
-
Yang, W.1
Jiang, L.H.2
-
35
-
-
84891394018
-
Divalent cations potentiate TRPV1 channel by lowering the heat activation threshold
-
Cao X, Ma L, Yang F, Wang K, Zheng J (2014) Divalent cations potentiate TRPV1 channel by lowering the heat activation threshold. J Gen Physiol 143: 75-90.
-
(2014)
J Gen Physiol
, vol.143
, pp. 75-90
-
-
Cao, X.1
Ma, L.2
Yang, F.3
Wang, K.4
Zheng, J.5
-
36
-
-
85027947630
-
A residue in the TRPM2 channel outer pore is crucial in determining species-dependent sensitivity to extracellular acidic pH
-
Zou J, Yang W, Beech DJ, Jiang LH (2011) A residue in the TRPM2 channel outer pore is crucial in determining species-dependent sensitivity to extracellular acidic pH. Pflugers Arch 462: 293-302.
-
(2011)
Pflugers Arch
, vol.462
, pp. 293-302
-
-
Zou, J.1
Yang, W.2
Beech, D.J.3
Jiang, L.H.4
-
37
-
-
37549023848
-
Dissecting the facilitator and inhibitor allosteric metal sites of the P2X4 receptor channel: Critical roles of CYS132 for zinc potentiation and ASP138 for copper inhibition
-
Coddou C, Acuna-Castillo C, Bull P, Huidobro-Toro JP (2007) Dissecting the facilitator and inhibitor allosteric metal sites of the P2X4 receptor channel: critical roles of CYS132 for zinc potentiation and ASP138 for copper inhibition. J Biol Chem 282: 36879-36886.
-
(2007)
J Biol Chem
, vol.282
, pp. 36879-36886
-
-
Coddou, C.1
Acuna-Castillo, C.2
Bull, P.3
Huidobro-Toro, J.P.4
-
38
-
-
37349124727
-
Identification of key residues coordinating functional inhibition of P2X7 receptors by zinc and copper
-
Liu X, Surprenant A, Mao HJ, Roger S, Xia R, et al. (2008) Identification of key residues coordinating functional inhibition of P2X7 receptors by zinc and copper. Mol Pharmacol 73: 252-259.
-
(2008)
Mol Pharmacol
, vol.73
, pp. 252-259
-
-
Liu, X.1
Surprenant, A.2
Mao, H.J.3
Roger, S.4
Xia, R.5
-
39
-
-
0033815963
-
A point mutation in the pore region alters gating, Ca(2+) blockage, and permeation of olfactory cyclic nucleotide-gated channels
-
Gavazzo P, Picco C, Eismann E, Kaupp UB, Menini A (2000) A point mutation in the pore region alters gating, Ca(2+) blockage, and permeation of olfactory cyclic nucleotide-gated channels. J Gen Physiol 116: 311-326.
-
(2000)
J Gen Physiol
, vol.116
, pp. 311-326
-
-
Gavazzo, P.1
Picco, C.2
Eismann, E.3
Kaupp, U.B.4
Menini, A.5
-
40
-
-
84862508553
-
Copper dysfunction in Alzheimer's disease: From meta-analysis of biochemical studies to new insight into genetics
-
Squitti R (2012) Copper dysfunction in Alzheimer's disease: from meta-analysis of biochemical studies to new insight into genetics. J Trace Elem Med Biol 26: 93-96.
-
(2012)
J Trace Elem Med Biol
, vol.26
, pp. 93-96
-
-
Squitti, R.1
-
41
-
-
51749108879
-
Role of copper in human neurological disorders
-
Desai V, Kaler SG (2008) Role of copper in human neurological disorders. Am J Clin Nutr 88: 855S-858S.
-
(2008)
Am J Clin Nutr
, vol.88
, pp. 855S-858S
-
-
Desai, V.1
Kaler, S.G.2
|