External Cu 2+ inhibits human epithelial Na + channels by binding at a subunit interface of extracellular domains

Journal of Biological Chemistry

Volumn 286, Issue 31, 2011, Pages 27436-27446

  Chen, Jingxin ^a   Myerburg, Mike M ^a   Passero, Christopher J ^a   Winarski, Katie L ^a   Sheng, Shaohu ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUID HOMEOSTASIS; CHANNEL COMPLEX; COUNTER-CLOCKWISE; CURRENT-VOLTAGE RELATIONSHIP; EXTRACELLULAR; EXTRACELLULAR DOMAINS; INHIBITORY EFFECT; POTENT INHIBITOR; SOLUTION PH; STRUCTURAL BASIS; SUBDOMAIN; SUBUNIT INTERFACES; TIME COURSE; XENOPUS OOCYTE;

MAMMALS; SODIUM; TRANSITION METALS;

BINDING SITES;

COPPER ION; EPITHELIAL SODIUM CHANNEL; EPITHELIAL SODIUM CHANNEL ALPHA SUBUNIT; EPITHELIAL SODIUM CHANNEL BETA SUBUNIT; EPITHELIAL SODIUM CHANNEL GAMMA SUBUNIT; SODIUM ION; UNCLASSIFIED DRUG; COPPER;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING SITE; BODY FLUID; CHANNEL GATING; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; FLUID BALANCE; HUMAN; HUMAN CELL; IC 50; INHIBITION KINETICS; NONHUMAN; OOCYTE; PH; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; SODIUM CURRENT; XENOPUS; ANIMAL; CELL CULTURE; DRUG ANTAGONISM; GENETICS; METABOLISM; SITE DIRECTED MUTAGENESIS;

ANIMALS; CELLS, CULTURED; COPPER; EPITHELIAL SODIUM CHANNEL; HUMANS; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; XENOPUS;

EID: 79961008694     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.232058     Document Type: Article

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