A novel solid dispersion system for natural product-loaded medicine: Silymarin-loaded solid dispersion with enhanced oral bioavailability and hepatoprotective activity

Journal of Microencapsulation

Volumn 31, Issue 7, 2014, Pages 619-626

  Hwang, Du Hyeong ^a   Kim, Yong Il ^a   Cho, Kwan Hyung ^a   Poudel, Bijay Kumar ^a   Choi, Ju Yeon ^a   Kim, Dong Wuk ^b   Shin, Young Jun ^b   Bae, Ok Nam ^b   Yousaf, Abid Mehmood ^b   Yong, Chul Soon ^a   Kim, Jong Oh ^a   Choi, Han Gon ^b  

^a Yeungnam University   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

Bioavailability; Hepatoprotection; Silymarin; Solid dispersion; Solubility

Indexed keywords

ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; POLYSORBATE 80; POVIDONE; SILYMARIN; ANTIOXIDANT; PHARMACEUTICAL VEHICLES AND ADDITIVES; POLYSORBATE; SURFACTANT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG HALF LIFE; DRUG SOLUBILITY; DRUG STABILITY; HYDROPHILICITY; IN VIVO STUDY; LIVER PROTECTION; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PHYSICAL CHEMISTRY; RAT; REPEATED DRUG DOSE; SCANNING ELECTRON MICROSCOPY; SOLID DISPERSION SYSTEM; SPRAY DRYING; SURFACE PROPERTY; TIME TO MAXIMUM PLASMA CONCENTRATION; TOXIC HEPATITIS; X RAY POWDER DIFFRACTION; ANIMAL; BIOAVAILABILITY; CARBON TETRACHLORIDE POISONING; CHEMISTRY; COMPARATIVE STUDY; METABOLISM; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; BIOLOGICAL AVAILABILITY; CARBON TETRACHLORIDE POISONING; PHARMACEUTIC AIDS; POLYSORBATES; POVIDONE; RATS; SILYMARIN; SURFACE-ACTIVE AGENTS;

EID: 84911494518     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.3109/02652048.2014.911375     Document Type: Article

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