Inhibition of AMP deaminase activity does not improve glucose control in rodent models of insulin resistance or diabetes

Chemistry and Biology

Volumn 21, Issue 11, 2014, Pages 1486-1496

  Admyre, Therese ^a   Amrot Fors, Lena ^a   Andersson, Maria ^a   Bauer, Martin ^a   Bjursell, Mikael ^a   Drmota, Tomas ^a   Hallén, Stefan ^a   Hartleib Geschwindner, Judith ^a   Lindmark, Bo ^a   Liu, Jianming ^a   Löfgren, Lars ^a   Rohman, Mattias ^a   Selmi, Nidhal ^a   Wallenius, Kristina ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE MONOPHOSPHATE DEAMINASE; ADENOSINE MONOPHOSPHATE DEAMINASE INHIBITOR; GLUCOSE; HYDROLASE INHIBITOR; INSULIN; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; AMPD1 PROTEIN, MOUSE; ENZYME INHIBITOR; GLUCOSE BLOOD LEVEL; MOLECULAR LIBRARY; PROTEIN BINDING; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETIC OBESITY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG TREATMENT FAILURE; ENZYME INHIBITION; EX VIVO STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HIGH THROUGHPUT SCREENING; IC50; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID DIET; LIVER CELL; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; ORAL GLUCOSE TOLERANCE TEST; PHENOTYPE; PHYSICAL CHEMISTRY; RAT; REACTION OPTIMIZATION; RODENT MODEL; STRUCTURE ACTIVITY RELATION; TISSUE HOMOGENATE; ANALYSIS; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BLOOD; C57BL MOUSE; CELL CULTURE; CHEMISTRY; CYTOLOGY; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; GENETICS; KNOCKOUT MOUSE; METABOLISM; MOLECULAR LIBRARY; MOUSE MUTANT; OBESITY; PATHOLOGY; PHARMACOLOGY; SPRAGUE DAWLEY RAT; THERAPEUTIC USE;

RODENTIA;

AMP DEAMINASE; ANIMALS; BLOOD GLUCOSE; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FEMALE; HEPATOCYTES; INSULIN; INSULIN RESISTANCE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, OBESE; OBESITY; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SMALL MOLECULE LIBRARIES;

EID: 84911490585     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2014.09.011     Document Type: Article

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