Evaluation of sgRNA target sites for CRISPR-mediated repression of TP53

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Lawhorn, Ingrid E B ^a   Ferreira, Joshua P ^a   Wang, Clifford L ^a  

^a Stanford University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEAD CAS9 PROTEIN; GENOMIC RNA; MESSENGER RNA; NUCLEASE; PROTEIN P53; RNA; SMALL GUIDE RNA; UNCLASSIFIED DRUG; CRISPR ASSOCIATED PROTEIN; GUIDE RNA;

ARTICLE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; DNA CLEAVAGE; DNA FLANKING REGION; GENE REPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; MUTAGENESIS; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN DOMAIN; RNA ANALYSIS; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION TERMINATION; TUMOR SUPPRESSOR GENE; GENE VECTOR; GENETICS; HEK293 CELL LINE; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION;

CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-ASSOCIATED PROTEINS; GENETIC VECTORS; HEK293 CELLS; HUMANS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, GUIDE; RNA, MESSENGER; TRANSCRIPTION INITIATION SITE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84911488260     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0113232     Document Type: Article

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