Muscle ectopic fat deposition contributes to anabolic resistance in obese sarcopenic old rats through eIF2α activation

Aging Cell

Volumn 13, Issue 6, 2014, Pages 1001-1011

  Tardif, Nicolas ^a,b   Salles, Jérôme ^a,b   Guillet, Christelle ^a,b   Tordjman, Joan ^c   Reggio, Sophie ^c   Landrier, Jean François ^d   Giraudet, Christophe ^a,b   Patrac, Véronique ^a,b   Bertrand Michel, Justine ^e   Migne, Carole ^a,b   Collin, Marie Laure ^a,b   Chardigny, Jean Michel ^a,b   Boirie, Yves ^a,b,f   Walrand, Stéphane ^a,b  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b CRNH AUVERGNE   (France)

^c CENTRE DE RECHERCHE DES CORDELIERS   (France)

^d INSERM   (France)

^e CHU PURPAN   (France)

^f UNIVERSITY HOSPITAL OF CLERMONT FERRAND   (France)

Author keywords

Ceramide; EIF2 signaling; High fat diet; Muscle protein synthesis; Obesity; Sarcopenia

Indexed keywords

CERAMIDE; INITIATION FACTOR 2; INSULIN; MUSCLE PROTEIN; PALMITIC ACID; PERK KINASE; PROTEIN KINASE R;

ADIPOGENESIS; ADIPOSE TISSUE; ADULT; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CELL DAMAGE; CONTROLLED STUDY; FATTY ACID OXIDATION; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRACELLULAR SIGNALING; LIPID DIET; LIPID STORAGE; LOW FAT DIET; MALE; MUSCLE LEVEL; MUSCLE METABOLISM; MUSCLE MITOCHONDRION; MYOFIBROSIS; MYOTUBE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; SARCOPENIA; TISSUE EXPANSION; TRANSLATION INITIATION; ANIMAL; DISEASE MODEL; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; WISTAR RAT;

RATTUS;

ADIPOSE TISSUE; AGING; ANIMALS; CERAMIDES; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; EIF-2 KINASE; EUKARYOTIC INITIATION FACTOR-2; INSULIN RESISTANCE; MALE; MUSCLE, SKELETAL; OBESITY; RATS; RATS, WISTAR; SARCOPENIA; SIGNAL TRANSDUCTION;

EID: 84911459019     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12263     Document Type: Article

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