Molecular basis determining inhibition/activation of nociceptive receptor TRPA1 protein: A single amino acid dictates species-specific actions of the most potent mammalian TRPA1 antagonist

Journal of Biological Chemistry

Volumn 289, Issue 46, 2014, Pages 31927-31939

  Banzawa, Nagako ^a   Saito, Shigeru ^b   Imagawa, Toshiaki ^c   Kashio, Makiko ^b   Takahashi, Kenji ^a   Tominaga, Makoto ^b   Ohta, Toshio ^a  

^a TOTTORI UNIVERSITY   (Japan)

^b OKAZAKI INSTITUTE FOR INTEGRATIVE BIOSCIENCE   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; ANIMALS; MAMMALS;

AMINO ACID RESIDUES; MOLECULAR BASIS; NON-SELECTIVE CATION CHANNELS; PHARMACOLOGICAL PROPERTIES; THERMAL STIMULI; TRANS-MEMBRANE DOMAINS; TRANSIENT RECEPTOR POTENTIALS; VERTEBRATE SPECIES;

AMINO ACIDS;

A 967079; AMINO ACID; ANALGESIC AGENT; ANKYRIN; CALCIUM; CATION CHANNEL; MEMBRANE PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1 ANTAGONIST; UNCLASSIFIED DRUG; CALCIUM CHANNEL; NERVE PROTEIN; OXIME; PROTEIN BINDING; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRPA1 PROTEIN, HUMAN; TRPA1 PROTEIN, MOUSE;

ANURA; ARTICLE; CHICKEN; DRUG IDENTIFICATION; HUMAN; INFLAMMATORY PAIN; MECHANICAL STIMULATION; NOCICEPTION; PAIN RECEPTOR; POINT MUTATION; PROTEIN DOMAIN; PROTEIN FUNCTION; SENSITIVITY ANALYSIS; SPECIES DIFFERENCE; SPINAL GANGLION; THERMAL STIMULUS TEST; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CHICK EMBRYO; HEK293 CELL LINE; METABOLISM; MOUSE; MUTATION; NERVE CELL; PATCH CLAMP TECHNIQUE; PROTEIN TERTIARY STRUCTURE;

MAMMALIA;

ANALGESICS; ANIMALS; CALCIUM; CALCIUM CHANNELS; CHICK EMBRYO; CHICKENS; GANGLIA, SPINAL; HEK293 CELLS; HUMANS; MICE; MUTATION; NERVE TISSUE PROTEINS; NEURONS; OXIMES; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SPECIES SPECIFICITY; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84911453940     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.586891     Document Type: Article

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