CCR7 regulates cell migration and invasion through JAK2/STAT3 in metastatic squamous cell carcinoma of the head and neck

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Liu, Fa Yu ^a   Safdar, Jawad ^a   Li, Zhen Ning ^a   Fang, Qi Gen ^b   Zhang, Xu ^b   Xu, Zhong Fei ^a   Sun, Chang Fu ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b ZHENGZHOU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BETA ACTIN; CHEMOKINE RECEPTOR CCR7; JANUS KINASE 2; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; STAT3 PROTEIN; UVOMORULIN; VIMENTIN; CCR7 PROTEIN, HUMAN; JAK2 PROTEIN, HUMAN; STAT3 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CANCER STAGING; CELL MIGRATION; CELL MIGRATION ASSAY; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; METASTASIS; METASTASIS INHIBITION; PATHOLOGIST; SIGNAL TRANSDUCTION; TUMOR CELL LINE; TUMOR INVASION; TUMOR MICROENVIRONMENT; WESTERN BLOTTING; BIOSYNTHESIS; CELL MOTION; GENE EXPRESSION REGULATION; GENETICS; HEAD AND NECK TUMOR; METABOLISM; PATHOLOGY; SQUAMOUS CELL CARCINOMA;

CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL MOVEMENT; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAD AND NECK NEOPLASMS; HUMANS; JANUS KINASE 2; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; RECEPTORS, CCR7; STAT3 TRANSCRIPTION FACTOR;

EID: 84911401026     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/415375     Document Type: Article

References (34)

1. Greenlee R. T., Hill-Harmon M. B., Murray T., Thun M., Cancer statistics, 2001. Ca-A Cancer Journal for Clinicians 2001 51 1 15 36 10.3322/canjclin.51.1.15 2-s2.0-0035114558
2. Xia X., Liu K., Zhang H., Shang Z., Correlation between CCR7 expression and lymph node metastatic potential of human tongue carcinoma. Oral Diseases 2014 10.1111/odi.12228 2-s2.0-84895913286
3. van den Bosch T., Koopmans A. E., Vaarwater J., van den Berg M., de Klein A., Verdijk R. M., Chemokine receptor CCR7 expression predicts poor outcome in uveal melanoma and relates to liver metastasis whereas expression of CXCR4 is not of clinical relevance. Investigative Ophthalmology & Visual Science 2013 54 12 7354 7361 10.1167/iovs.13-12407 2-s2.0-84887328963
4. Guo J., Lou W., Ji Y., Zhang S., Effect of CCR7, CXCR4 and VEGF-C on the lymph node metastasis of human pancreatic ductal adenocarcinoma. Oncology Letters 2013 5 5 1572 1578 10.3892/ol.2013.1261 2-s2.0-84875725364
5. Wang W.-N., Chen Y., Zhang Y.-D., Hu T.-H., The regulatory mechanism of CCR7 gene expression and its involvement in the metastasis and progression of gastric cancer. Tumor Biology 2013 34 3 1865 1871 10.1007/s13277-013-0728-9 2-s2.0-84878693607
6. Zhen-jin Z., Peng L., Fa-yu L., Liyan S., Chang-fu S., PKC α take part in CCR7/NF- B autocrine signaling loop in CCR7-positive squamous cell carcinoma of head and neck. Molecular and Cellular Biochemistry 2011 357 1-2 181 187 10.1007/s11010-011-0888-0 2-s2.0-84857436690
7. Zhao Z.-J., Liu F.-Y., Li P., Ding X., Zong Z.-H., Sun C.-F., CCL19-induced chemokine receptor 7 activates the phosphoinositide-3 kinase-mediated invasive pathway through Cdc42 in metastatic squamous cell carcinoma of the head and neck. Oncology Reports 2011 25 3 729 737 10.3892/or.2010.1109 2-s2.0-79551609975
8. Li P., Zhao Z.-J., Liu F.-Y., Sun L.-Y., Ding X., Zhang W.-Z., Shang D.-H., Sun C.-F., The chemokine receptor 7 regulates cell adhesion and migration via β 1 integrin in metastatic squamous cell carcinoma of the head and neck. Oncology Reports 2010 24 4 989 995 10.3892/or-00000946 2-s2.0-77957358572
9. Li P., Liu F., Sun L., Zhao Z., Ding X., Shang D., Xu Z., Sun C., Chemokine receptor 7 promotes cell migration and adhesion in metastatic squamous cell carcinoma of the head and neck by activating integrin α v β 3. International Journal of Molecular Medicine 2011 27 5 679 687 10.3892/ijmm.2011.628 2-s2.0-79952940424
10. Liu F.-Y., Zhao Z.-J., Li P., Ding X., Zong Z.-H., Sun C.-F., Mammalian target of rapamycin (mTOR) is involved in the survival of cells mediated by chemokine receptor 7 through PI3K/Akt in metastatic squamous cell carcinoma of the head and neck. British Journal of Oral and Maxillofacial Surgery 2010 48 4 291 296 10.1016/j.bjoms.2009.06.007 2-s2.0-77952320737
11. Liu F. Y., Zhao Z. J., Li P., Ding X., Sun C. F., Effect of rapamycin combined with cisplatin on head and neck squamous cancer cells regulated by CCL19. Zhonghua Kou Qiang Yi Xue Za Zhi 2011 46 4 197 200
12. Liu F. Y., Zhao Z. J., Li P., Ding X., Sun C. F., The effect of CCL19 on the viability of head and neck squamous cancer cells. Shanghai Kou Qiang Yi Xue 2010 19 2 158 161
13. Liu F. Y., Zhao Z. J., Li P., Ding X., Guo N., Yang L. L., Zong Z. H., Sun C. F., NF- B participates in chemokine receptor 7-mediated cell survival in metastatic squamous cell carcinoma of the head and neck. Oncology Reports 2011 25 2 383 391 10.3892/or.2010.1090 2-s2.0-78651357788
14. Liu F. Y., Zhao Z. J., Huang S. H., Sun C. F., Role of PDTC in CCL19 regulating the activity of human head and neck squamous cancer cells. Journal of China Medical University 2008 37 6 847 849
15. Yang L., Liu F., Xu Z., Guo N., Zheng X., Sun C., Chemokine receptor 7 via proline-rich tyrosine kinase-2 upregulates the chemotaxis and migration ability of squamous cell carcinoma of the head and neck. Oncology Reports 2012 28 5 1659 1664 10.3892/or.2012.1989 2-s2.0-84866469804
16. Colomiere M., Findlay J., Ackland L., Ahmed N., Epidermal growth factor-induced ovarian carcinoma cell migration is associated with JAK2/STAT3 signals and changes in the abundance and localization of α 6 β 1 integrin. The International Journal of Biochemistry & Cell Biology 2009 41 5 1034 1045 10.1016/j.biocel.2008.09.018 2-s2.0-59649086123
17. Lakshmanan I., Ponnusamy M. P., Das S., Chakraborty S., Haridas D., Mukhopadhyay P., Lele S. M., Batra S. K., MUC16 induced rapid G2/M transition via interactions with JAK2 for increased proliferation and anti-apoptosis in breast cancer cells. Oncogene 2012 31 7 805 817 10.1038/onc.2011.297 2-s2.0-84857118144
18. Murata T., Noguchi P. D., Puri R. K., IL-13 induces phosphorylation and activation of JAK2 janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling. Journal of Immunology 1996 156 8 2972 2978 2-s2.0-0030584699
19. Wang L., Yi T., Zhang W., Pardoll D. M., Yu H., IL-17 enhances tumor development in carcinogen-induced skin cancer. Cancer Research 2010 70 24 10112 10120 10.1158/0008-5472.CAN-10-0775 2-s2.0-78650359166
20. Pfeiffer M., Hartmann T. N., Leick M., Catusse J., Schmitt-Graeff A., Burger M., Alternative implication of CXCR4 in JAK2STAT3 activation in small cell lung cancer. British Journal of Cancer 2009 100 12 1949 1956 10.1038/sj.bjc.6605068 2-s2.0-67349104436
21. Hao M., Zheng J., Hou K., Wang J., Chen X., Lu X., Bo J., Xu C., Shen K., Wang J., Role of chemokine receptor CXCR7 in bladder cancer progression. Biochemical Pharmacology 2012 84 2 204 214 10.1016/j.bcp.2012.04.007 2-s2.0-84861232588
22. Wang J., Zhang X., Thomas S. M., Grandis J. R., Wells A., Chen Z., Ferris R. L., Chemokine receptor 7 activates phosphoinositide-3 kinase-mediated invasive and prosurvival pathways in head and neck cancer cells independent of EGFR. Oncogene 2005 24 38 5897 5904 10.1038/sj.onc.1208740 2-s2.0-26944443745
23. Mburu Y. K., Wang J., Wood M. A., Walker W. H., Ferris R. L., CCR7 mediates inflammation-associated tumor progression. Immunologic Research 2006 36 1-3 61 72 10.1385/IR:36:1:61 2-s2.0-33947152097
24. Chen J., Wang J., Lin L., He L., Wu Y., Zhang L., Yi Z., Chen Y., Pang X., Liu M., Inhibition of STAT3 signaling pathway by nitidine chloride suppressed the angiogenesis and growth of human gastric cancer. Molecular Cancer Therapeutics 2012 11 2 277 287 10.1158/1535-7163.MCT-11-0648 2-s2.0-84863151419
25. Chang Q., Bournazou E., Sansone P., Berishaj M., Gao S. P., Daly L., Wels J., Theilen T., Granitto S., Zhang X., Cotari J., Alpaugh M. L., de Stanchina E., Manova K., Li M., Bonafe M., Ceccarelli C., Taffurelli M., Santini D., Altan-Bonnet G., Kaplan R., Norton L., Nishimoto N., Huszar D., Lyden D., Bromberg J., The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis. Neoplasia 2013 15 7 848 862 10.1593/neo.13706 2-s2.0-84879731392
26. Izumi K., Fang L.-Y., Mizokami A., Namiki M., Li L., Lin W.-J., Chang C., Targeting the androgen receptor with siRNA promotes prostate cancer metastasis through enhanced macrophage recruitment via CCL2/CCR2-induced STAT3 activation. EMBO Molecular Medicine 2013 5 9 1383 1401 10.1002/emmm.201202367 2-s2.0-84883366629
27. Lee J. H., Chiang S. Y., Nam D., Chung W.-S., Na Y.-S., Sethi G., Ahn K. S., Capillarisin inhibits constitutive and inducible STAT3 activation through induction of SHP-1 and SHP-2 tyrosine phosphatases. Cancer Letters 2014 345 1 140 148 10.1016/j.canlet.2013.12.008 2-s2.0-84893776889
28. Shi C.-S., Kehrl J. H., Pyk2 amplifies epidermal growth factor and c-Src-induced Stat3 activation. The Journal of Biological Chemistry 2004 279 17 17224 17231 10.1074/jbc.M311875200 2-s2.0-2342421810
29. Vogt P. K., Hart J. R., PI3K and STAT3: a new alliance. Cancer Discovery 2011 1 6 481 486 10.1158/2159-8290.CD-11-0218 2-s2.0-84866019998
30. Moon S.-H., Kim D.-K., Cha Y., Jeon I., Song J., Park K.-S., PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell line. International Journal of Oncology 2013 42 3 921 928 10.3892/ijo.2013.1765 2-s2.0-84873695296
31. Behrens J., Cadherins and catenins: role in signal transduction and tumor progression. Cancer and Metastasis Reviews 1999 18 1 15 30 10.1023/A:1006200102166 2-s2.0-0032843036
32. Xiong H., Hong J., Du W., Lin Y.-W., Ren L.-L., Wang Y.-C., Su W.-Y., Wang J.-L., Cui Y., Wang Z.-H., Fang J.-Y., Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition. The Journal of Biological Chemistry 2012 287 8 5819 5832 10.1074/jbc.M111.295964 2-s2.0-84863115473
33. Avtanski D. B., Nagalingam A., Bonner M. Y., Arbiser J. L., Saxena N. K., Sharma D., Honokiol inhibits epithelial-mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E-cadherin axis. Molecular Oncology 2014 8 3 565 580 10.1016/j.molonc.2014.01.004 2-s2.0-84899486834
34. Deng J., Liang H., Zhang R., Sun D., Pan Y., Liu Y., Zhang L., Hao X., STAT3 is associated with lymph node metastasis in gastric cancer. Tumor Biology 2013 34 5 2791 2800 10.1007/s13277-013-0837-5 2-s2.0-84885419344