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Volumn 11, Issue 2, 2012, Pages 277-287

Inhibition of STAT3 signaling pathway by nitidine chloride suppressed the angiogenesis and growth of human gastric cancer

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; CYCLIN D1; HEPARIN; JANUS KINASE 2; MATRIGEL; NITIDINE; PROTEIN BCL XL; STAT3 PROTEIN; VASCULOTROPIN;

EID: 84863151419     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-11-0648     Document Type: Article
Times cited : (156)

References (50)
  • 3
    • 77951686858 scopus 로고    scopus 로고
    • Angiogenesis and lymphangiogenesis of gastric cancer
    • Kitadai Y. Angiogenesis and lymphangiogenesis of gastric cancer. J Oncol 2010;2010:468725.
    • (2010) J Oncol , vol.2010 , pp. 468725
    • Kitadai, Y.1
  • 4
    • 77954668887 scopus 로고    scopus 로고
    • Angiogenesis inhibitors: Current strategies and future prospects
    • Cook KM, Figg WD. Angiogenesis inhibitors: current strategies and future prospects. CA Cancer J Clin 2010;60:222-43.
    • (2010) CA Cancer J Clin , vol.60 , pp. 222-243
    • Cook, K.M.1    Figg, W.D.2
  • 5
    • 70349513281 scopus 로고    scopus 로고
    • AZD6244 (ARRY-142886) enhances the therapeutic efficacy of sorafenib in mouse models of gastric cancer
    • Yang S, Ngo VC, Lew GB, Chong LW, Lee SS, Ong WJ, et al. AZD6244 (ARRY-142886) enhances the therapeutic efficacy of sorafenib in mouse models of gastric cancer. Mol Cancer Ther 2009;8:2537-45.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2537-2545
    • Yang, S.1    Ngo, V.C.2    Lew, G.B.3    Chong, L.W.4    Lee, S.S.5    Ong, W.J.6
  • 8
    • 0036554816 scopus 로고    scopus 로고
    • Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention
    • Buettner R, Mora LB, Jove R. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin Cancer Res 2002;8:945-54. (Pubitemid 35177340)
    • (2002) Clinical Cancer Research , vol.8 , Issue.4 , pp. 945-954
    • Buettner, R.1    Mora, L.B.2    Jove, R.3
  • 10
    • 1442285917 scopus 로고    scopus 로고
    • Inactivation of Stat3 in tumor cells: Releasing a brake on immune responses against cancer?
    • DOI 10.1016/S1535-6108(04)00028-5, PII S1535610804000285
    • Gamero AM, Young HA, Wiltrout RH. Inactivation of Stat3 in tumor cells: releasing a brake on immune responses against cancer? Cancer Cell 2004;5:111-2. (Pubitemid 38283795)
    • (2004) Cancer Cell , vol.5 , Issue.2 , pp. 111-112
    • Gamero, A.M.1    Young, H.A.2    Wiltrout, R.H.3
  • 11
    • 77955633773 scopus 로고    scopus 로고
    • Fluacrypyrim, a novel STAT3 activation inhibitor, induces cell cycle arrest and apoptosis in cancer cells harboring constitutively-active STAT3
    • Yu ZY, Huang R, Xiao H, Sun WF, Shan YJ, Wang B, et al. Fluacrypyrim, a novel STAT3 activation inhibitor, induces cell cycle arrest and apoptosis in cancer cells harboring constitutively-active STAT3. Int J Cancer 2010;127:1259-70.
    • (2010) Int J Cancer , vol.127 , pp. 1259-1270
    • Yu, Z.Y.1    Huang, R.2    Xiao, H.3    Sun, W.F.4    Shan, Y.J.5    Wang, B.6
  • 12
    • 34548693457 scopus 로고    scopus 로고
    • Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells
    • DOI 10.1158/1541-7786.MCR-06-0348
    • Pathak AK, Bhutani M, Nair AS, Ahn KS, Chakraborty A, Kadara H, et al. Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells. Mol Cancer Res 2007;5:943-55. (Pubitemid 47416671)
    • (2007) Molecular Cancer Research , vol.5 , Issue.9 , pp. 943-955
    • Pathak, A.K.1    Bhutani, M.2    Nair, A.S.3    Kwang, S.A.4    Chakraborty, A.5    Kadara, H.6    Guha, S.7    Sethi, G.8    Aggarwal, B.B.9
  • 13
    • 69349095364 scopus 로고    scopus 로고
    • Anticancer strategies involving the vasculature
    • Heath VL, Bicknell R. Anticancer strategies involving the vasculature. Nat Rev Clin Oncol 2009;6:395-404.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 395-404
    • Heath, V.L.1    Bicknell, R.2
  • 14
    • 0042844744 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the period 1981-2002
    • DOI 10.1021/np030096l
    • Newman DJ, Cragg GM, Snader KM. Natural products as sources of new drugs over the period 1981-2002. J Nat Prod 2003;66:1022-37. (Pubitemid 36909859)
    • (2003) Journal of Natural Products , vol.66 , Issue.7 , pp. 1022-1037
    • Newman, D.J.1    Cragg, G.M.2    Snader, K.M.3
  • 15
    • 33749587618 scopus 로고    scopus 로고
    • Benzophenanthridine alkaloids from Zanthoxylum nitidum (Roxb.) DC, and their analgesic and anti-inflammatory activities
    • DOI 10.1002/cbdv.200690108
    • Hu J, Zhang WD, Liu RH, Zhang C, Shen YH, Li HL, et al. Benzophenanthridine alkaloids from Zanthoxylum nitidum (Roxb.) DC, and their analgesic and anti-inflammatory activities. Chem Biodivers 2006;3:990-5. (Pubitemid 44540931)
    • (2006) Chemistry and Biodiversity , vol.3 , Issue.9 , pp. 990-995
    • Hu, J.1    Zhang, W.-D.2    Liu, R.-H.3    Zhang, C.4    Shen, Y.-H.5    Li, H.-L.6    Liang, M.-J.7    Xu, X.-K.8
  • 16
    • 75749123095 scopus 로고    scopus 로고
    • Tumor-selective cytotoxicity of benzo[c]phenanthridine derivatives from Toddalia asiatica Lam
    • Iwasaki H, Okabe T, Takara K, Toda T, Shimatani M, Oku H. Tumor-selective cytotoxicity of benzo[c]phenanthridine derivatives from Toddalia asiatica Lam. Cancer Chemother Pharmacol 2010;65:719-26.
    • (2010) Cancer Chemother Pharmacol , vol.65 , pp. 719-726
    • Iwasaki, H.1    Okabe, T.2    Takara, K.3    Toda, T.4    Shimatani, M.5    Oku, H.6
  • 17
    • 84863166328 scopus 로고    scopus 로고
    • Nitidine chloride-induced apoptosis of human osteosarcoma cells and its mechanism
    • Xu Q, Li ZX, Ye ZM. [Nitidine chloride-induced apoptosis of human osteosarcoma cells and its mechanism]. Nan Fang Yi Ke Da Xue Xue Bao 2011;31:361-4.
    • (2011) Nan Fang Yi Ke Da Xue Xue Bao , vol.31 , pp. 361-364
    • Xu, Q.1    Li, Z.X.2    Ye, Z.M.3
  • 18
    • 0035984785 scopus 로고    scopus 로고
    • Molecular characterization of recombinant Pneumocystis carinii topoisomerase I: Differential interactions with human topoisomerase I poisons and pentamidine
    • DOI 10.1128/AAC.46.7.2145-2154.2002
    • van Dross RT, Sanders MM. Molecular characterization of recombinant Pneumocystis carinii topoisomerase I: differential interactions with human topoisomerase I poisons and pentamidine. Antimicrob Agents Chemother 2002;46:2145-54. (Pubitemid 34665909)
    • (2002) Antimicrobial Agents and Chemotherapy , vol.46 , Issue.7 , pp. 2145-2154
    • Van Drosst, R.T.1    Sanders, M.M.2
  • 19
    • 0026062445 scopus 로고
    • Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase
    • Tan GT, Pezzuto JM, Kinghorn AD, Hughes SH. Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. J Nat Prod 1991;54:143-54.
    • (1991) J Nat Prod , vol.54 , pp. 143-154
    • Tan, G.T.1    Pezzuto, J.M.2    Kinghorn, A.D.3    Hughes, S.H.4
  • 20
    • 48949087080 scopus 로고    scopus 로고
    • ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma (HCC) cells, and inhibits growth and vascularization in vivo
    • Moser C, Lang SA, Mori A, Hellerbrand C, Schlitt HJ, Geissler EK, et al. ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma (HCC) cells, and inhibits growth and vascularization in vivo. BMC Cancer 2008;8:206.
    • (2008) BMC Cancer , vol.8 , pp. 206
    • Moser, C.1    Lang, S.A.2    Mori, A.3    Hellerbrand, C.4    Schlitt, H.J.5    Geissler, E.K.6
  • 21
    • 34548059697 scopus 로고    scopus 로고
    • Caffeic acid and its synthetic derivative CADPE suppress tumor angiogenesis by blocking STAT3-mediated VEGF expression in human renal carcinoma cells
    • DOI 10.1093/carcin/bgm130
    • Jung JE, Kim HS, Lee CS, Park DH, Kim YN, Lee MJ, et al. Caffeic acid and its synthetic derivative CADPE suppress tumor angiogenesis by blocking STAT3-mediated VEGF expression in human renal carcinoma cells. Carcinogenesis 2007;28:1780-7. (Pubitemid 47289042)
    • (2007) Carcinogenesis , vol.28 , Issue.8 , pp. 1780-1787
    • Jung, J.E.1    Kim, H.S.2    Lee, C.-S.3    Park, D.-H.4    Kim, Y.-N.5    Lee, M.-J.6    Lee, J.W.7    Park, J.-W.8    Kim, M.-S.9    Ye, S.K.10    Chung, M.-H.11
  • 22
    • 58349092759 scopus 로고    scopus 로고
    • Morelloflavone, a biflavonoid, inhibits tumor angiogenesis by targeting rho GTPases and extracellular signal-regulated kinase signaling pathways
    • Pang X, Yi T, Yi Z, Cho SG, Qu W, Pinkaew D, et al. Morelloflavone, a biflavonoid, inhibits tumor angiogenesis by targeting rho GTPases and extracellular signal-regulated kinase signaling pathways. Cancer Res 2009;69:518-25.
    • (2009) Cancer Res , vol.69 , pp. 518-525
    • Pang, X.1    Yi, T.2    Yi, Z.3    Cho, S.G.4    Qu, W.5    Pinkaew, D.6
  • 23
    • 67651005688 scopus 로고    scopus 로고
    • Acetyl-11-keto-beta-boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis
    • Pang X, Yi Z, Zhang X, Sung B, Qu W, Lian X, et al. Acetyl-11-keto-beta- boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis. Cancer Res 2009;69:5893-900.
    • (2009) Cancer Res , vol.69 , pp. 5893-5900
    • Pang, X.1    Yi, Z.2    Zhang, X.3    Sung, B.4    Qu, W.5    Lian, X.6
  • 24
    • 39149100314 scopus 로고    scopus 로고
    • Capsiate, a nonpungent capsaicin-like compound, inhibits angiogenesis and vascular permeability via a direct inhibition of Src kinase activity
    • DOI 10.1158/0008-5472.CAN-07-2799
    • Pyun BJ, Choi S, Lee Y, Kim TW, Min JK, Kim Y, et al. Capsiate, a nonpungent capsaicin-like compound, inhibits angiogenesis and vascular permeability via a direct inhibition of Src kinase activity. Cancer Res 2008;68:227-35. (Pubitemid 351380124)
    • (2008) Cancer Research , vol.68 , Issue.1 , pp. 227-235
    • Pyun, B.-J.1    Choi, S.2    Lee, Y.3    Kim, T.-W.4    Min, J.-K.5    Kim, Y.6    Kim, B.-D.7    Kim, J.-H.8    Kim, T.-Y.9    Kim, Y.-M.10    Kwon, Y.-G.11
  • 26
    • 33646851955 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing nuclear factor-kappaB activation
    • DOI 10.1074/jbc.M507213200
    • Takada Y, Gillenwater A, Ichikawa H, Aggarwal BB. Suberoylanilide hydroxamic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing nuclear factor-kappaB activation. J Biol Chem 2006;281:5612-22. (Pubitemid 43847658)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.9 , pp. 5612-5622
    • Takada, Y.1    Gillenwater, A.2    Ichikawa, H.3    Aggarwal, B.B.4
  • 27
    • 0141955061 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells
    • Bharti AC, Donato N, Aggarwal BB. Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells. J Immunol 2003;171:3863-71. (Pubitemid 37254592)
    • (2003) Journal of Immunology , vol.171 , Issue.7 , pp. 3863-3871
    • Bharti, A.C.1    Donato, N.2    Aggarwal, B.B.3
  • 28
    • 0029069540 scopus 로고
    • Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein
    • Yu CL, Meyer DJ, Campbell GS, Larner AC, Carter-Su C, Schwartz J, et al. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science 1995;269:81-3.
    • (1995) Science , vol.269 , pp. 81-83
    • Yu, C.L.1    Meyer, D.J.2    Campbell, G.S.3    Larner, A.C.4    Carter-Su, C.5    Schwartz, J.6
  • 29
    • 0035652459 scopus 로고    scopus 로고
    • The IL-7 receptor controls the accessibility of the TCRgamma locus by Stat5 and histone acetylation
    • DOI 10.1016/S1074-7613(01)00230-8
    • Ye SK, Agata Y, Lee HC, Kurooka H, Kitamura T, Shimizu A, et al. The IL-7 receptor controls the accessibility of the TCRgamma locus by Stat5 and histone acetylation. Immunity 2001;15:813-23. (Pubitemid 34008508)
    • (2001) Immunity , vol.15 , Issue.5 , pp. 813-823
    • Ye, S.-K.1    Agata, Y.2    Lee, H.-C.3    Kurooka, H.4    Kitamura, T.5    Shimizu, A.6    Honjo, T.7    Ikuta, K.8
  • 30
    • 77950234271 scopus 로고    scopus 로고
    • Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway
    • Pang X, Yi Z, Zhang J, Lu B, Sung B, Qu W, et al. Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway. Cancer Res 2010;70:1951-9.
    • (2010) Cancer Res , vol.70 , pp. 1951-1959
    • Pang, X.1    Yi, Z.2    Zhang, J.3    Lu, B.4    Sung, B.5    Qu, W.6
  • 32
    • 63849095654 scopus 로고    scopus 로고
    • STAT3 as a prognostic marker in human gastric cancer
    • Jackson CB, Giraud AS. STAT3 as a prognostic marker in human gastric cancer. J Gastroenterol Hepatol 2009;24:505-7.
    • (2009) J Gastroenterol Hepatol , vol.24 , pp. 505-507
    • Jackson, C.B.1    Giraud, A.S.2
  • 34
    • 79958227890 scopus 로고    scopus 로고
    • Oral administration of Penta-O-galloyl-{beta}-D-glucose Suppresses Triple-negative Breast Cancer Xenograft Growth and Metastasis in Strong Association with JAK1-STAT3 Inhibition
    • Lee HJ, Seo NJ, Jeong SJ, Park Y, Jung DB, Koh W, et al. Oral administration of Penta-O-galloyl-{beta}-D-glucose Suppresses Triple-negative Breast Cancer Xenograft Growth and Metastasis in Strong Association with JAK1-STAT3 Inhibition. Carcinogenesis 2011;32:804-11.
    • (2011) Carcinogenesis , vol.32 , pp. 804-811
    • Lee, H.J.1    Seo, N.J.2    Jeong, S.J.3    Park, Y.4    Jung, D.B.5    Koh, W.6
  • 35
    • 77953690135 scopus 로고    scopus 로고
    • Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells
    • Pandey MK, Sung B, Aggarwal BB. Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells. Int J Cancer 2010;127:282-92.
    • (2010) Int J Cancer , vol.127 , pp. 282-292
    • Pandey, M.K.1    Sung, B.2    Aggarwal, B.B.3
  • 36
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • DOI 10.1056/NEJMra0706596
    • Kerbel RS. Tumor angiogenesis. N Engl J Med 2008;358:2039-49. (Pubitemid 351656458)
    • (2008) New England Journal of Medicine , vol.358 , Issue.19 , pp. 2039-2049
    • Kerbel, R.S.1
  • 37
    • 43149102244 scopus 로고    scopus 로고
    • Drug Insight: Antiangiogenic therapies for gastrointestinal cancers - Focus on monoclonal antibodies
    • DOI 10.1038/ncpgasthep1097, PII NCPGASTHEP1097
    • Reinacher-Schick A, Pohl M, Schmiegel W. Drug insight: antiangiogenic therapies for gastrointestinal cancers-focus on monoclonal antibodies. Nat Clin Pract Gastroenterol Hepatol 2008;5:250-67. (Pubitemid 351637911)
    • (2008) Nature Clinical Practice Gastroenterology and Hepatology , vol.5 , Issue.5 , pp. 250-267
    • Reinacher-Schick, A.1    Pohl, M.2    Schmiegel, W.3
  • 38
    • 79957870537 scopus 로고    scopus 로고
    • (-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via Stat3 in gastric cancer
    • Zhu BH, Chen HY, Zhan WH, Wang CY, Cai SR, Wang Z, et al. (-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via Stat3 in gastric cancer. World J Gastroenterol 2011;17:2315-25.
    • (2011) World J Gastroenterol , vol.17 , pp. 2315-2325
    • Zhu, B.H.1    Chen, H.Y.2    Zhan, W.H.3    Wang, C.Y.4    Cai, S.R.5    Wang, Z.6
  • 40
    • 39549102220 scopus 로고    scopus 로고
    • STAT3: A critical transcription activator in angiogenesis
    • DOI 10.1002/med.20101
    • Chen Z, Han ZC. STAT3: a critical transcription activator in angiogenesis. Med Res Rev 2008;28:185-200. (Pubitemid 351281185)
    • (2008) Medicinal Research Reviews , vol.28 , Issue.2 , pp. 185-200
    • Chen, Z.1    Zhong, C.H.2
  • 41
    • 51049106854 scopus 로고    scopus 로고
    • Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa
    • Meng Y, Tang W, Dai Y, Wu X, Liu M, Ji Q, et al. Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa. Mol Cancer Ther 2008;7:2192-202.
    • (2008) Mol Cancer Ther , vol.7 , pp. 2192-2202
    • Meng, Y.1    Tang, W.2    Dai, Y.3    Wu, X.4    Liu, M.5    Ji, Q.6
  • 42
    • 0037064121 scopus 로고    scopus 로고
    • ErbB-2 activates Stat3alpha in a Src- and JAK2-dependent manner
    • DOI 10.1074/jbc.M112438200
    • Ren Z, Schaefer TS. ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner. J Biol Chem 2002;277:38486-93. (Pubitemid 35154707)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.41 , pp. 38486-38493
    • Ren, Z.1    Schaefer, T.S.2
  • 43
    • 0037160057 scopus 로고    scopus 로고
    • Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain
    • DOI 10.1074/jbc.M204255200
    • Schreiner SJ, Schiavone AP, Smithgall TE. Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain. J Biol Chem 2002;277:45680-7. (Pubitemid 36159180)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.47 , pp. 45680-45687
    • Schreiner, S.J.1    Schiavone, A.P.2    Smithgall, T.E.3
  • 44
    • 80052962987 scopus 로고    scopus 로고
    • Indirubin inhibits tumor growth by anti-tumor angiogenesis through blocking VEGFR2 mediated JAK/STAT3 signaling in endothelial cell
    • Zhang X, Song Y, Wu Y, Dong Y, Lai L, Zhang J, et al. Indirubin inhibits tumor growth by anti-tumor angiogenesis through blocking VEGFR2 mediated JAK/STAT3 signaling in endothelial cell. Int J Cancer 2011;129:2502-11.
    • (2011) Int J Cancer , vol.129 , pp. 2502-2511
    • Zhang, X.1    Song, Y.2    Wu, Y.3    Dong, Y.4    Lai, L.5    Zhang, J.6
  • 45
    • 78649763564 scopus 로고    scopus 로고
    • Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2-STAT3 signaling pathway
    • Dong Y, Lu B, Zhang X, Zhang J, Lai L, Li D, et al. Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2-STAT3 signaling pathway. Carcinogenesis 2010;31:2097-104.
    • (2010) Carcinogenesis , vol.31 , pp. 2097-2104
    • Dong, Y.1    Lu, B.2    Zhang, X.3    Zhang, J.4    Lai, L.5    Li, D.6
  • 46
    • 0036782706 scopus 로고    scopus 로고
    • Transcription factors as targets for cancer therapy
    • Darnell JE Jr. Transcription factors as targets for cancer therapy. Nat Rev Cancer 2002;2:740-9.
    • (2002) Nat Rev Cancer , vol.2 , pp. 740-749
    • Darnell Jr., J.E.1
  • 47
    • 0033593230 scopus 로고    scopus 로고
    • Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL
    • Finucane DM, Bossy-Wetzel E, Waterhouse NJ, Cotter TG, Green DR. Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL. J Biol Chem 1999;274:2225-33.
    • (1999) J Biol Chem , vol.274 , pp. 2225-2233
    • Finucane, D.M.1    Bossy-Wetzel, E.2    Waterhouse, N.J.3    Cotter, T.G.4    Green, D.R.5
  • 49
    • 77953926671 scopus 로고    scopus 로고
    • Downregulation of Bcl-xL and Mcl-1 is sufficient to induce cell death in mesothelioma cells highly refractory to conventional chemotherapy
    • Varin E, Denoyelle C, Brotin E, Meryet-Figuiere M, Giffard F, Abeilard E, et al. Downregulation of Bcl-xL and Mcl-1 is sufficient to induce cell death in mesothelioma cells highly refractory to conventional chemotherapy. Carcinogenesis 2010;31:984-93.
    • (2010) Carcinogenesis , vol.31 , pp. 984-993
    • Varin, E.1    Denoyelle, C.2    Brotin, E.3    Meryet-Figuiere, M.4    Giffard, F.5    Abeilard, E.6
  • 50
    • 74049125626 scopus 로고    scopus 로고
    • Bcl-XL and MCL-1 constitute pertinent targets in ovarian carcinoma and their concomitant inhibition is sufficient to induce apoptosis
    • Brotin E, Meryet-Figuiere M, Simonin K, Duval RE, Villedieu M, Leroy-Dudal J, et al. Bcl-XL and MCL-1 constitute pertinent targets in ovarian carcinoma and their concomitant inhibition is sufficient to induce apoptosis. Int J Cancer 2010;126:885-95.
    • (2010) Int J Cancer , vol.126 , pp. 885-895
    • Brotin, E.1    Meryet-Figuiere, M.2    Simonin, K.3    Duval, R.E.4    Villedieu, M.5    Leroy-Dudal, J.6


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