Balancing glycolysis and mitochondrial OXPHOS: Lessons from the hematopoietic system and exercising muscles

Mitochondrion

Volumn 19, Issue Part A, 2014, Pages 3-7

  Haran, Michal ^a   Gross, Atan ^b  

^a KAPLAN MEDICAL CENTER   (Israel)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Exercise; Glycolysis; Hematopoiesis; Oxidative phosphorylation (OXPHOS)

Indexed keywords

LACTIC ACID;

ARTICLE; CELL MOTILITY; CYTOSOL; ENERGY; ENZYME MECHANISM; GLYCOLYSIS; HEMATOPOIESIS; HOMEOSTASIS; METABOLIC REGULATION; METABOLISM; MITOCHONDRION; MUSCLE EXERCISE; NUTRIENT; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; ANIMAL; ENERGY METABOLISM; HEMATOPOIETIC SYSTEM; PHYSIOLOGY; SKELETAL MUSCLE;

ANIMALS; ENERGY METABOLISM; GLYCOLYSIS; HEMATOPOIETIC SYSTEM; MITOCHONDRIA; MUSCLE, SKELETAL; OXIDATIVE PHOSPHORYLATION;

EID: 84911372506     PISSN: 15677249     EISSN: 18728278     Source Type: Journal    
DOI: 10.1016/j.mito.2014.09.007     Document Type: Article

References (54)

1. Ameln H., Gustafsson T., Sundberg C.J., Okamoto K., Jansson E., Poellinger L., Makino Y. Physiological activation of hypoxia inducible factor-1 in human skeletal muscle. FASEB J. 2005, 19:1009-1011.
2. Andres R., Cader G., Zierler K.L. The quantitatively minor role of carbohydrate in oxidative metabolism by skeletal muscle in the basal state. Measurements of oxygen and glucose uptake and carbon dioxide and lactate production in the forearm. J. Clin. Invest. 1956, 671-682.
3. Balaban R.S., Nemoto S., Finkel T. Mitochondria, oxidants, and aging. Cell 2005, 120:483-495.
4. Bélanger M., Allaman I., Magistretti P.J. Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. Cell Metab. 2011, 14:724-738.
5. Breslav I.S., Segizbaeva M.O., Isaev G.G. Does the respiratory system limit the aerobic working capacity of humans?. Hum. Physiol. 2000, 26:481-487.
6. Bricker D.K., Taylor E.B., Schell J.C., Orsak T., Boutron A., Chen Y.-C., Cox J.E., Cardon C.M., Van Vranken J.G., Dephoure N., Redin C., Boudina S., Gygi S.P., Brivet M., Thummel C.S., Rutter J. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science 2012, 337:96-100.
7. Brooks G.A. Lactate shuttles in nature. Biochem. Soc. Trans. 2002, 30:258-264.
8. Brooks G.a. Lactate: link between glycolytic and oxidative metabolism. Sports Med. 2007, 37:341-343.
9. Brooks G.a Cell-cell and intracellular lactate shuttles. J. Physiol. 2009, 587:5591-5600.
10. Brooks G., Dubouchaud H., Brown M., Sicurello James P., Butz C.Eric. Role of mitochondrial lactate dehydrogenase and lactate oxidation in the intracellular lactate shuttle. PNAS 1999, 96:1129-1134.
11. Brunelle J.K., Bell E.L., Quesada N.M., Vercauteren K., Tiranti V., Zeviani M., Scarpulla R.C. Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation. Cell Metab. 2005, 1:409-414.
12. Cantley L.C. The phosphoinositide 3-kinase pathway. Science 2002, 296:1655-1657.
13. Choi H.B., Gordon G.R.J., Zhou N., Tai C., Rungta R.L., Martinez J., Milner T.A., Ryu J.K., McLarnon J.G., Tresguerres M., Levin L.R., Buck J., MacVicar B.A. Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase. Neuron 2012, 75:1094-1104.
14. Conley K.E., Kemper W.F., Crowther G.J. Limits to sustainable muscle performance: interaction between glycolysis and oxidative phosphorylation. J. Exp. Biol. 2001, 3194:3189-3194.
15. Dan L., Klimenkova O., Klimiankou M., Klusman J.-H., van den Heuvel-Eibrink M.M., Reinhardt D., Welte K., Skokowa J. The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells. Haematologica 2012, 97:551-559.
16. Delp M.D., Laghlin M.H. Regulation of skeletal muscle perfusion during exercise. Acta Physiol. Scand. 1998, 162:411-419.
17. Folmes C.D.L., Nelson T.J., Dzeja P.P., Terzic A. Energy metabolism plasticity enables stemness programs. Ann. N. Y. Acad. Sci. 2013, 1254:82-89.
18. Gladden L.B. Lactate metabolism: a new paradigm for the third millennium. J. Physiol. 2004, 558:5-30.
19. Gomes A.P., Price N.L., Ling A.J.Y., Moslehi J.J., Montgomery M.K., Rajman L., White J.P., Teodoro J.S., Wrann C.D., Hubbard B.P., Mercken E.M., Palmeira C.M., de Cabo R., Rolo A.P., Turner N., Bell E.L., Sinclair D. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell 2013, 155:1624-1638.
20. Haller R., Visig J. Spontaneous "second wind" and glucose-induced "second wind" in McArdle disease. Arch. Neurol. 2002, 59:1395-1402.
21. Herzig S., Raemy E., Montessuit S., Veuthey J.-L., Zamboni N., Westermann B., Kunji E.R.S., Martinou J. Identification and functional expression of the mitochondrial pyruvate carrier. Science 2012, 337:93-96.
22. Ito K., Suda T. Metabolic requirements for the maintenance of self-renewing stem cells. Nat. Rev. Mol. Cell Biol. 2014, 15:243-256.
23. Ito K, Carracedo A., Weiss D., Arai F., Ala U., Avigan D.E., Schafer Z.T., Evans R.M., Suda T., Lee C., Pandolfi P.P. A PML-PPAR- δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nat. Med. 2012, 18:1350-1358.
24. Jeppesen J., Kiens B. Regulation and limitations to fatty acid oxidation during exercise. J. Physiol. 2012, 590:1059-1068.
25. Karpatkin S., Helmreich E., Carl F. Regulation of glycolysis in muscle: II. Effect of stimulation and epinepherine in isolated frog sartorius muscle. J. Biol. Chem. 1964, 1004:3130-3145.
26. Kawamata H., Tiranti V., Magrané J., Chinopoulos C., Manfredi G. adPEO mutations in ANT1 impair ADP-ATP translocation in muscle mitochondria. Hum. Mol. Genet. 2011, 20:2964-2974.
27. Larsson C.A., Cote G., Quintas-Cardama A. The changing mutational landscape of acute myeloid leukemia and myelodysplastic syndrome. Mol. Cancer Res. 2013, 11.
28. Maryanovich M., Oberkovitz G., Niv H., Vorobiyov L., Zaltsman Y., Brenner O., Lapidot T., Jung S., Gross A. The ATM-BID pathway regulates quiescence and survival of haematopoietic stem cells. Nat. Cell Biol. 2012, 14:535-541.
29. Mason S.D., Howlett R.a, Kim M.J., Olfert I.M., Hogan M.C., McNulty W., Hickey R.P., Wagner P.D., Kahn C.R., Giordano F.J., Johnson R.S. Loss of skeletal muscle HIF-1alpha results in altered exercise endurance. PLoS Biol. 2004, 2:e288.
30. Meléndez A., Neufeld T.P. The cell biology of autophagy in metazoans: a developing story. Development 2008, 135:2347-2360.
31. Milovanova T.N., Bhopale V.M., Sorokina E.M., Moore J.S., Hunt T.K., Hauer-Jensen M., Velazquez O.C., Thom S.R. Lactate stimulates vasculogenic stem cells via the thioredoxin system and engages an autocrine activation loop involving hypoxia-inducible factor 1. Mol. Cell. Biol. 2008, 28:6248-6261.
32. Nombela-Arrieta C., Pivarnik G., Winkel B., Canty K.J., Harley B., Mahoney J.E., Park S.-Y., Lu J., Protopopov A., Silberstein L.E. Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment. Nat. Cell Biol. 2013, 15:533-543.
33. Ochocki J.D., Simon M.C. Nutrient-sensing pathways and metabolic regulation in stem cells. J. Cell Biol. 2013, 203:23-33.
34. Ogawa M. Differentiation and proliferation of hematopoietic stem cells. Blood 1993, 81:2844-2853.
35. Park S., Chapuis N., Tamburini J., Bardet V., Cornillet-lefebvre P., Willems L., Green A., Mayeux P., Lacombe C., Bouscary D. Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia. Haematologica 2009, 95:819-828.
36. Philp A., Macdonald A.L., Watt P.W. Lactate-a signal coordinating cell and systemic function. J. Exp. Biol. 2005, 208:4561-4575.
37. Puzio-Kuter A.M. The role of p53 in metabolic regulation. Genes Cancer 2011, 2:385-391.
38. Rozier M.D., Zata V.J., Ellsworth M.L. Lactate interferes with ATP release from red blood cells. Am. J. Physiol. Heart Circ. Physiol. 2007, 292:H3038-H3042.
39. Ryu J.M., Han H.J. L-threonine regulates G1/S phase transition of mouse embryonic stem cells via PI3K/Akt, MAPKs, and mTORC pathways. J. Biol. Chem. 2011, 286:23667-23678.
40. Seita J., Weissman I.L. Hematopoietic stem cell: self-renewal versus differentiation. Wiley Interdiscip. Rev. Syst. Biol. Med. 2010, 2:640-653.
41. Shiloh Y., Ziv Y. The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nat. Rev. Mol. Cell Biol. 2013, 14:197-210.
42. Simsek T., Kocabas F., Zheng J., Deberardinis R.J., Mahmoud A.I., Olson E.N., Schneider J.W., Zhang C.C., Sadek H.A. The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. Stem Cell 2010, 7:380-390.
43. Stefano N.D.E., Argov Z., Matthews P.M. Impairment of mitochondrial oxidative metabolism in McArdle's disease. Muscle Nerve 1996, 19:764-769.
44. Suda T., Takubo K., Semenza G.L. Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell Stem Cell 2011, 9:298-310.
45. Takebe K., Takahashi-Iwanaga H., Iwanaga T. Intensified expressions of a monocarboxylate transporter in consistently renewing tissues of the mouse. Biomed. Res. 2011, 32:293-301.
46. Takubo K., Goda N., Yamada W., Iriuchishima H., Ikeda E., Kubota Y., Shima H., Johnson R.S., Hirao A., Suematsu M., Suda T. Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell Stem Cell 2010, 7:391-402.
47. Takubo K., Nagamatsu G., Kobayashi C.I., Nakamura-Ishizu A., Kobayashi H., Ikeda E., Goda N., Rahimi Y., Johnson R.S., Soga T., Hirao A., Suematsu M., Suda T. Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. Cell Stem Cell 2013, 12:49-61.
48. Tannahill G.M., Curtis A.M., Adamik J., Palsson-McDermott E.M., McGettrick A.F., Goel G., Frezza C., Bernard N.J., Kelly B., Foley N.H., Zheng L., Gardet A., Tong Z., Jany S.S., Corr S.C., Haneklaus M., Caffrey B.E., Pierce K., Walmsley S., Beasley F.C., Cummins E., Nizet V., Whyte M., Taylor C.T., Lin H., Masters S.L., Gottlieb E., Kelly V.P., Clish C., Auron P.E., Xavier R.J., O'Neill L.A. Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature 2013, 496:238-242.
49. Vander Heiden M.G., Cantley L.C., Thompson C.B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009, 324:1029-1033.
50. Vozza A., Parisi G., De Leonardis F., Lasorsa F.M., Castegna A., Amorese D., Marmo R., Calcagnile V.M., Palmieri L., Ricquier D., Paradies E., Scarcia P., Palmieri F., Bouillaud F., Fiermonte G. UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation. Proc. Natl. Acad. Sci. U. S. A. 2014, 111:960-965.
51. Wasserman K., Beaver W.L., Davis J.A., Pu J.Z., Heber D., Whipp B.J. Lactate, pyruvate and lactate-to-pyruvate ratio during exercise and recovery 1985, 59:935-940.
52. Wellmann S., Guschmann M., Griethe W., Eckert C., von Stackelberg a., Lottaz C., Moderegger E., Einsiedel H.G., Eckardt K.-U., Henze G., Seeger K., Stackelberg A. Activation of the HIF pathway in childhood ALL, prognostic implications of VEGF. Leukemia 2004, 18:926-933.
53. Yu W.-M., Shen J., Jovanovic O., Pohl E.E., Gerson S.L., Finkel T., Broxmeyer H.E., Qu C.-K. Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation. Cell Stem Cell 2013, 12:62-74.
54. Zieker D., Schäfer R., Glatzle J., Nieselt K., Coerper S., Kluba T., Northoff H., Königsrainer A., Hunt T.K., Beckert S. Lactate modulates gene expression in human mesenchymal stem cells. Langenbecks Arch. Surg. 2008, 393:297-301.