Lactate: Link between glycolytic and oxidative metabolism

Sports Medicine

Volumn 37, Issue 4-5, 2007, Pages 341-343

  Brooks, George A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LACTIC ACID;

AEROBIC METABOLISM; ANOXIA; ASTROCYTE; CONFERENCE PAPER; ENERGY TRANSFER; GLUCONEOGENESIS; GLYCOGENOLYSIS; GLYCOLYSIS; HEART MUSCLE; MARATHON RUNNER; MUSCLE CONTRACTION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

EID: 34247862319     PISSN: 01121642     EISSN: None     Source Type: Journal    
DOI: 10.2165/00007256-200737040-00017     Document Type: Conference Paper

References (11)

1. Fletcher WM, Hopkins FG. Lactic acid in amphibian muscle. J Physiol 1907; 35: 247-309
2. Brooks GA. Lactate: glycolytic end product and oxidative substrate during sustained exercise in mammals. The 'Lactate Shuttle'. In Gilles R, editor. Circulation, respiration, and metabolism: current comparative approaches. Berlin: Springer-Verlag, 1985: 208-18
3. Brooks GA, Dubouchaud H, Brown M, et al. Role of mitochondrial lactic dehydrogenase and lactate oxidation in the 'intracellular lactate shuttle. Proc Natl Acad Sci U S A 1999; 96: 1129-34
4. Pellerin L, Pellegri G, Bittar PG, et al. Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle. Dev Neurosci 1998; 20: 291-9
5. Donovan CM, Brooks GA. Endurance training affects lactate clearance, not lactate production. Am J Physiol 1983; 244: E83-92
6. Bergman BC, Wolfel EE, Butterfield GE, et al. Active muscle and whole body lactate kinetics after endurance training in men. J Appl Physiol 1999; 87: 1684-96
7. Dubouchaud H, Butterfield GE, Wolfel EE, et al. Endurance training, expression and physiology of LDH, MCT1 and MCT4 in human skeletal muscle. Am J Physiol 2000; 278: E571-9
8. Hashimoto T, Hussien R, Brooks GA. Colocalization of MCT1, CD147 and LDH in mitochondrial inner membrane of L6 cells: evidence of a mitochondrial lactate oxidation complex. Am J Physiol Endocrinol Metab 2006; 290: 1237-44
9. Hashimoto T, Masuda S, Taguchi S, et al. Immunohistochemical analysis of MCT1, MCT2 and MCT4 expression in rat plantaris muscle. J Physiol 2005; 567: 121-9
10. Roth DA, Brooks GA. Lactate and pyruvate transport is dominated using a pH gradient-sensitive carrier in rat skeletal muscle sarcolemmal vesicles. Arch Biochem Biophys 1990; 279: 386-94
11. O'Brien MJ, Viguie CA, Mazzeo RS, et al. Carbohydrate depen-dence during marathon running. Med Sci Sports Exerc 1993; 25: 1009-17