Clostridium difficile sortase recognizes a (S/P)PXTG sequence motif and can accommodate diaminopimelic acid as a substrate for transpeptidation

FEBS Letters

Volumn 588, Issue 23, 2014, Pages 4325-4333

  Van Leeuwen, Hans C ^a   Klychnikov, Oleg I ^a   Menks, Mica A C ^a   Kuijper, Ed J ^a   Drijfhout, Jan W ^a   Hensbergen, Paul J ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Adhesion; Diaminopimelic acid; Mass spectrometry; Peptidoglycan; Transpeptidation; Virulence

Indexed keywords

DIAMINOPIMELIC ACID; SORTASE; AMINOACYLTRANSFERASE; BACTERIAL PROTEIN; CYSTEINE PROTEINASE; PEPTIDE; PROTEIN BINDING; RECOMBINANT PROTEIN; SORTASE A;

AMINO ACID SEQUENCE; ARTICLE; CLOSTRIDIUM DIFFICILE; CONTROLLED STUDY; COVALENT BOND; GENE ACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR RECOGNITION; NONHUMAN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SEQUENCE ALIGNMENT; SORTASE GENE; BIOLOGY; BIOSYNTHESIS; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; METABOLISM; MOLECULAR GENETICS; PEPTOCLOSTRIDIUM DIFFICILE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINOACYLTRANSFERASES; BACTERIAL PROTEINS; CLOSTRIDIUM DIFFICILE; COMPUTATIONAL BIOLOGY; CYSTEINE ENDOPEPTIDASES; DIAMINOPIMELIC ACID; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 84910664729     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2014.09.041     Document Type: Article

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