Structural and computational studies of the Staphylococcus aureus sortase B-substrate complex reveal a substrate-stabilized oxyanion hole

Journal of Biological Chemistry

Volumn 289, Issue 13, 2014, Pages 8891-8902

  Jacobitz, Alex W ^a   Wereszczynski, Jeff ^b   Yi, Sung Wook ^a   Amer, Brendan R ^a   Huang, Grace L ^a   Nguyen, Angelyn V ^a   Sawaya, Michael R ^a   Jung, Michael E ^a   McCammon, J Andrew ^b   Clubb, Robert T ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDES; AMINO ACIDS; BACTERIA; CELL MEMBRANES; COMPUTATIONAL CHEMISTRY; CRYSTAL STRUCTURE; ENZYMES; HYDROGEN BONDS; POSITIVE IONS; STAPHYLOCOCCUS AUREUS;

CATALYTIC INTERMEDIATES; CATALYTIC MECHANISMS; COMPUTATIONAL STUDIES; ENZYME SUPERFAMILIES; GRAM-POSITIVE BACTERIUM; MOLECULAR DYNAMICS SIMULATIONS; SUBSTRATE COMPLEXES; SUBSTRATE RECOGNITION;

MOLECULAR DYNAMICS;

ARGININE; CARRIER PROTEIN; GLUTAMIC ACID; PROTEIN ISDC; SORTASE; SORTASE B; THREONINE; UNCLASSIFIED DRUG; AMINOACYLTRANSFERASE; BACTERIAL PROTEIN; CYSTEINE PROTEINASE; OXYGEN; SIGNAL PEPTIDE;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; MOLECULAR DYNAMICS; MUTAGENESIS; OXYANION HOLE; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; BIOCATALYSIS; CHEMISTRY; CYTOLOGY; ENZYME STABILITY; ENZYMOLOGY; FIMBRIA; METABOLISM; X RAY CRYSTALLOGRAPHY;

AMINOACYLTRANSFERASES; ARGININE; BACTERIAL PROTEINS; BIOCATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYSTEINE ENDOPEPTIDASES; ENZYME STABILITY; FIMBRIAE, BACTERIAL; HYDROGEN BONDING; MOLECULAR DYNAMICS SIMULATION; OXYGEN; PROTEIN SORTING SIGNALS; STAPHYLOCOCCUS AUREUS;

EID: 84897469604     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.509273     Document Type: Article

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