Clostridium difficile has a single sortase, SrtB, that can be inhibited by small-molecule inhibitors

BMC Microbiology

Volumn 14, Issue 1, 2014, Pages

  Donahue, Elizabeth H ^a   Dawson, Lisa F ^a   Valiente, Esmeralda ^a   Firth Clark, Stuart ^b   Major, Meriel R ^b   Littler, Eddy ^b   Perrior, Trevor R ^b   Wren, Brendan W ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b Domainex Ltd   (United Kingdom)

Author keywords

Clostridium difficile; Cysteine protease; Enzyme inhibitors; Enzyme kinetics; Fluorescence resonance energy transfer (FRET); Sortase

Indexed keywords

ALANINE; CELL MEMBRANE PROTEIN; CYSTEINE; CYSTEINE PROTEINASE; GLYCINE; SORTASE; THREONINE; ENZYME INHIBITOR; MEMBRANE PROTEIN; MUTANT PROTEIN; PEPTIDOGLYCAN; PEPTIDYLTRANSFERASE;

AMINO ACID SEQUENCE; ARTICLE; CELL WALL; CLOSTRIDIUM DIFFICILE; ENZYME ACTIVITY; ENZYME INHIBITION; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE MUTATION; IN VITRO STUDY; MASS SPECTROMETRY; NONHUMAN; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETICS; HYDROLYSIS; METABOLISM; MISSENSE MUTATION; PEPTOCLOSTRIDIUM DIFFICILE;

CLOSTRIDIUM DIFFICILE;

CATALYTIC DOMAIN; CELL WALL; CLOSTRIDIUM DIFFICILE; CYSTEINE; ENZYME INHIBITORS; HYDROLYSIS; MEMBRANE PROTEINS; MUTANT PROTEINS; MUTATION, MISSENSE; PEPTIDOGLYCAN; PEPTIDYL TRANSFERASES;

EID: 84906957812     PISSN: None     EISSN: 14712180     Source Type: Journal    
DOI: 10.1186/s12866-014-0219-1     Document Type: Article

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