The structure of the Staphylococcus aureus sortase-substrate complex reveals how the universally conserved LPXTG sorting signal is recognized

Journal of Biological Chemistry

Volumn 284, Issue 36, 2009, Pages 24465-24477

  Suree, Nuttee ^a   Liew, Chu Kong ^a,b   Villareal, Valerie A ^a   Thieu, William ^a   Fadeev, Evgeny A ^a,c   Clemens, Jeremy J ^a,d   Jung, Michael E ^a   Clubb, Robert T ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d WYETH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ACTIVE SITE RESIDUES; BACTERIAL PATHOGENS; CATALYTIC INTERMEDIATES; CELL WALLS; CHEMICAL SHIFT MAPPING; COVALENT COMPLEX; ENZYME MIMICS; GRAM-POSITIVE BACTERIUM; MOLECULAR BASIS; POLYPEPTIDE SUBSTRATES; SOLUTION STRUCTURES; SORTASE; SORTING SIGNALS; STAPHYLOCOCCUS AUREUS; SUBSTRATE COMPLEXES; SURFACE PROTEINS; TRANSPEPTIDATION REACTIONS; TRIGLYCINE; UNIFIED MODEL;

BACTERIA; BACTERIOLOGY; BINDING ENERGY; BINDING SITES; CELL MEMBRANES; ENZYMES; SIGNAL PROCESSING; SUBSTRATES;

CRYSTAL STRUCTURE;

MEMBRANE PROTEIN; SORTASE; TRIGLYCINE;

ARTICLE; BINDING SITE; CATALYSIS; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN TARGETING; PROTON NUCLEAR MAGNETIC RESONANCE; STAPHYLOCOCCUS AUREUS;

AMINOACYLTRANSFERASES; BACTERIAL PROTEINS; CATALYTIC DOMAIN; CYSTEINE ENDOPEPTIDASES; MODELS, CHEMICAL; MODELS, MOLECULAR; PEPTIDE MAPPING; PROTEIN SORTING SIGNALS; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; STAPHYLOCOCCUS AUREUS;

BACTERIA (MICROORGANISMS); POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 69949151708     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.022624     Document Type: Article

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