Oats and bowel disease: A systematic literature review

British Journal of Nutrition

Volumn 112, Issue , 2014, Pages S31-S43

  Thies, Frank ^a   Masson, Lindsey F ^b,c   Boffetta, Paolo ^d,e   Kris Etherton, Penny ^f  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

^c ROBERT GORDON UNIVERSITY   (United Kingdom)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^e INTERNATIONAL PREVENTION RESEARCH INSTITUTE   (France)

^f PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Bowel cancer; Bowel disease; Coeliac disease; Inflammatory bowel disease; Oats

Indexed keywords

CANCER INCIDENCE; CANCER RISK; CELIAC DISEASE; CEREAL; COCHRANE LIBRARY; COLORECTAL ADENOMA; COLORECTAL CANCER; CONSTIPATION; DIETARY COMPLIANCE; DIETARY INTAKE; EMBASE; ENTEROPATHY; FECES; FOOD INTAKE; GLUTEN FREE DIET; GRAIN; HUMAN; INFLAMMATORY BOWEL DISEASE; INFORMATION RETRIEVAL; INTESTINE FUNCTION; MEDLINE; OAT; OAT BRAN; REVIEW; RISK FACTOR; SYSTEMATIC REVIEW; ULCERATIVE COLITIS; COLONIC DISEASES; COLORECTAL NEOPLASMS; DIET; DIET THERAPY; DIETARY FIBER; THERAPEUTIC USE;

GLUTEN;

AVENA SATIVA; CELIAC DISEASE; CEREALS; COLITIS, ULCERATIVE; COLONIC DISEASES; COLORECTAL NEOPLASMS; CONSTIPATION; DIET; DIET, GLUTEN-FREE; DIETARY FIBER; GLUTENS; HUMANS;

EID: 84910627548     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114514002293     Document Type: Review

References (81)

1. World Cancer Research Fund/American Institute for Cancer Research (2007) Food, Nutrition, Physical Activity and the Prevention of Cancer: A Global Perspective. AICR Washington, DC.
2. Cancer Research UK (2012) Bowel cancer incidence statistics. http://www.cancerresearchuk.org/cancer-info/cancerstats/ types/bowel/incidence/uk-bowel-cancer-incidence-statistics #geog (accessed May 2013).
3. Aune D, Chan SM, Lau R, et al. (2011) Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response meta-analysis of prospective studies. BMJ 343, d6617.
4. Slavin JL, Martini MC, Jacobs DRJ, et al. (1999) Plausible mechanisms for the protectiveness of whole grains. Am J Clin Nutr 70, S459-S463.
5. Molodecky NA, Soon IS, Rabi DM, et al. (2012) Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology 142, 46-54.
6. Vernia P (2007) Butyrate in the treatment of ulcerative colitis. Dig Liver Dis Suppl 1, 27-30.
7. Di Sabatino A, Cazzola P, Ciccocioppo R, et al. (2007) Efficacy of butyrate in the treatment of mild to moderate Crohn's disease. Dig Liver Dis Suppl 1, 31-35.
8. Reilly NR & Green PHR (2012) Epidemiology and clinical presentations of celiac disease. Semin Immunopathol 34, 473-478.
9. Verdu EF, Armstrong DA & Murray JA (2009) Between celiac disease and irritable bowel syndrome: the "no man's land" of gluten sensitivity. Am J Gastroenterol 104, 1587-1594.
10. The Coeliac Society, United Kingdom (2011) Guidelines on coeliac disease and oats. http://www.coeliac.org.uk/healthcare- professionals/healthcare-professional-newsletters/october- hcp-exg/oats-in-the-gluten-free (accessed May 2013).
11. Ciclitira PJ, Dewar DH, McLaughlin SD, et al. (2010) The Management of Adults with Coeliac Disease. British Society of Gastroenterology, High Wycombe.
12. Hoffenberg EJ, Haas J, Drescher A, et al. (2002) A trial of oats in children with newly diagnosed celiac disease. J Pediatr 137, 361-366.
13. Janatuinen EK, Kemppainen TA, Julkunen RJ, et al. (2002) No harm from five year ingestion of oats in coeliac disease. Gut 50, 332-335.
14. Halpern SH & Douglas MJ (editors) (2005, 2007) Appendix: Jadad scale for reporting randomized controlled trials. pp. 237-238 (2005, 2007) Evidence-Based Obstetric Anesthesia. Blackwell Publishing Limited, Oxford.
15. Kashtan H, Stern HS, Jenkins DJ, et al. (1992) Colonic fermentation and markers of colorectal-cancer risk. Am J Clin Nutr 55, 723-728.
16. Macrae FA, Kilias D, Selbie L, et al. (1997) Effect of cereal fibre source and processing on rectal epithelial cell proliferation. Gut 41, 239-244.
17. Hallert C, Bjorck I, Nyman M, et al. (2003) Increasing fecal butyrate in ulcerative colitis patients by diet: controlled pilot study. Inflamm Bowel Dis 9, 116-121.
18. Zhang JX, Hallmans G, Andersson H, et al. (1992) Effect of oat bran on plasma cholesterol and bile acid excretion in nine subjects with ileostomies. Am J Clin Nutr 56, 99-105.
19. Baker PG & Read AE (1976) Oats and barley toxicity in coeliac patients. Postgrad Med J 52, 264-268.
20. Dissanayake AS, Truelove SC & Whitehead R (1974) Lack of harmful effect of oats on small-intestinal mucosa in coeliac disease. Br Med J 4, 189-191.
21. Kemppainen TA, Heikkinen MT, Ristikankare MK, et al. (2008) Unkilned and large amounts of oats in the coeliac disease diet: a randomized, controlled study. Scand J Gastroenterol 43, 1094-1101.
22. Kemppainen T, Heikkinen M, Ristikankare M, et al. (2009) Effect of unkilned and large amounts of oats on nutritional state of celiac patients in remission. e-SPEN 4, e30-e34.
23. Kemppainen TA, Heikkinen MT, Ristikankare MK, et al. (2010) Nutrient intakes during diets including unkilned and large amounts of oats in celiac disease. Eur J Clin Nutr 64, 62-67.
24. Lundin KEA, Nilsen EM, Scott HG, et al. (2003) Oats induced villous atrophy in coeliac disease. Gut 52, 1649-1652.
25. Reunala T, Collin P, Holm K, et al. (1998) Tolerance to oats in dermatitis herpetiformis. Gut 43, 490-493.
26. Hardman CM, Garioch JJ, Leonard JN, et al. (1997) Absence of toxicity of oats in patients with dermatitis herpetiformis. N Engl J Med 337, 1884-1887.
27. Janatuinen EK, Pikkarainen PH, Kemppainen TA, et al. (1995) A comparison of diets with and without oats in adults with celiac disease. N Engl J Med 333, 1033-1037.
28. Janatuinen EK, Kemppainen TA, Pikkarainen PH, et al. (2000) Lack of cellular and humoral immunological responses to oats in adults with coeliac disease. Gut 46, 327-331.
29. Kemppainen T, Janatuinen E, Holm K, et al. (2007) No observed local immunological response at cell level after five years of oats in adult coeliac disease. Scand J Gastroenterol 42, 54-59.
30. Peraaho M, Kaukinen K, Mustalahti K, et al. (2004) Effect of an oats-containing gluten-free diet on symptoms and quality of life in coeliac disease. A randomized study. Scand J Gastroenterol 39, 27-31.
31. Srinivasan U, Leonard N, Jones E, et al. (1996) Absence of oats toxicity in adult coeliac disease. BMJ 313, 1300-1301.
32. Feighery C, Srinivasan U & Carolan J (1998) Oats challenge in vivo does not activate coeliac disease as determined by immunohistological markers. In Changing Features of Coeliac Disease, pp. 103-108 [S Lohiniemi, editor]. Tampere: The Finnish Coeliac Society.
33. Størsrud S, Olsson M, Arvidsson Lenner R, et al. (2003) Adult coeliac patients do tolerate large amounts of oats. Eur J Clin Nutr 57, 163-169.
34. Størsrud S, Hulthen LR & Lenner RA (2003) Beneficial effects of oats in the gluten-free diet of adults with special reference to nutrient status, symptoms and subjective experiences. Br J Nutr 90, 101-107.
35. Abrahamsson L, Goranzon H, Karlstrom B, et al. (1994) Metabolic effects of oat bran and wheat bran in healthy women. Scand J Nutr Naringsforsk 38, 5-10.
36. Anderson JW, Story L, Sieling B, et al. (1984) Hypocholesterolemic effects of oat-bran or bean intake for hypercholesterolemic men. Am J Clin Nutr 40, 1146-1155.
37. Hosig KB, Shinnick FL, Johnson MD, et al. (1996) Comparison of large bowel function and calcium balance during soft wheat bran and oat bran consumption. Cereal Chem 73, 392-398.
38. Judd PA & Truswell S (1981) The effect of rolled oats on blood lipids and fecal steroid excretion in man. Am J Clin Nutr 34, 2061-2067.
39. Kirby RW, Anderson JW, Sieling B, et al. (1981) Oat-bran intake selectively lowers serum low-density lipoprotein cholesterol concentrations of hypercholesterolemic men. Am J Clin Nutr 34, 824-829.
40. Kretsch MJ, Crawford L & Calloway DH (1979) Some aspects of bile acid and urobilinogen excretion and fecal elimination in men given a rural Guatemalan diet and egg formulas with and without added oat bran. Am J Clin Nutr 32, 1492-1496.
41. Calloway DH & Kretsch MJ (1978) Protein and energy utilization in men given a rural Guatemalan diet and egg formulas with and without added oat bran. Am J Clin Nutr 31, 1118-1126.
42. Kristensen M & Bugel S (2011) A diet rich in oat bran improves blood lipids and hemostatic factors, and reduces apparent energy digestibility in young healthy volunteers. Eur J Clin Nutr 65, 1053-1058.
43. Marlett JA, Hosig KB, Vollendorf NW, et al. (1994) Mechanism of serum cholesterol reduction by oat bran. Hepatology 20, 1450-1457.
44. Noakes M, Clifton PM, Nestel PJ, et al. (1996) Effect of highamylose starch and oat bran on metabolic variables and bowel function in subjects with hypertriglyceridemia. Am J Clin Nutr 64, 944-951.
45. Sturtzel B & Elmadfa I (2008) Intervention with dietary fiber to treat constipation and reduce laxative use in residents of nursing homes. Ann Nutr Metab 52, Suppl. 1, 54-56.
46. Sturtzel B, Mikulits C, Gisinger C, et al. (2009) Use of fiber instead of laxative treatment in a geriatric hospital to improve the wellbeing of seniors. J Nutr Health Aging 13, 136-139.
47. Sturtzel B, Dietrich A, Wagner KH, et al. (2010) The status of vitamins B6, B12, folate, and of homocysteine in geriatric home residents receiving laxatives or dietary fiber. J Nutr Health Aging 14, 219-223.
48. Valle-Jones JC (1985) An open study of oat bran meal biscuits ('Lejfibre') in the treatment of constipation in the elderly. Curr Med Res Opin 9, 716-720.
49. Arffmann S, Hojgaard L, Giese B, et al. (1983) Effect of oat bran on lithogenic index of bile and bile acid metabolism. Digestion 28, 197-200.
50. Kestin M, Moss R, Clifton PM, et al. (1990) Comparative effects of three cereal brans on plasma lipids, blood pressure, and glucose metabolism in mildly hypercholesterolemic men. Am J Clin Nutr 52, 661-666.
51. Payler DK, Pomare EW, Heaton KW, et al. (1975) The effect of wheat bran on intestinal transit. Gut 16, 209-213.
52. Burkitt DP (1973) Some diseases characteristic of modern Western civilization. BMJ 1, 274-278.
53. Lipkin M, Reddy B, Newmark H, et al. (1999) Dietary factors in human colorectal cancer. Annu Rev Nutr 19, 545-586.
54. Schatzkin A, Mouw T, Park Y, et al. (2007) Dietary fiber and whole-grain consumption in relation to colorectal cancer in the NIH-AARP Diet and Health Study. Am J Clin Nutr 85, 1353-1360.
55. MacDonald TT (1995) Breakdown of tolerance to the intestinal bacterial flora in inflammatory bowel disease (IBD). Clin Exp Immunol 102, 445-447.
56. Prantera C (2008) What roles do antibiotics have in the treatment of IBD? Nat Clin Pract Gastroenterol Hepatol 5, 670-671.
57. Parkes M, Barrett JC, Prescott NJ, et al. (2007) Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet 39, 830-832.
58. Strober W & Fuss IJ (2011) Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology 140, 1756-1767.
59. Fuss IJ, Heller F, Boirivant M, et al. (2004) Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J Clin Invest 113, 1490-1497.
60. Heller F, Florian P, Bojarski C, et al. (2005) Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology 129, 550-564.
61. Kruis W, Fric P, Pokrotnieks J, et al. (2004) Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine. Gut 53, 1617-1623.
62. Tursi A, Brandimarte G, Papa A, et al. (2010) Treatment of relapsing mild-to-moderate ulcerative colitis with the probiotic VSL#3 as adjunctive to a standard pharmaceutical treatment: a double-blind, randomized, placebo-controlled study. Am J Gastroenterol 105, 2218-2227.
63. Vivas S, Ruiz de Morales JM, Fernandez M, et al. (2008) Agerelated clinical, serological, and histopathological features of celiac disease. Am J Gastroenterol 103, 2360-2365.
64. Ludvigsson JF, Ansved P, Fälth-Magnusson K, et al. (2004) Symptoms and signs have changed in Swedish children with coeliac disease. J Pediatr Gastroenterol Nutr 38, 181-186.
65. Rampertab SD, Pooran N, Brar P, et al. (2006) Trends in the presentation of celiac disease. Am J Med 119, 355.e9-355.e14.
66. Bergamaschi G, Markopoulos K, Albertini R, et al. (2008) Anemia of chronic disease and defective erythropoietin production in patients with celiac disease. Haematologica 93, 1785-1791.
67. Meyer D, Stavropolous S, Diamond B, et al. (2001) Osteoporosis in a North American adult population with celiac disease. Am J Gastroenterol 96, 112-119.
68. Chin RL, Latov N, Green PH, et al. (2004) Neurologic complications of celiac disease. J Clin Neuromuscul Dis 5, 129-137.
69. Thompson T (2003) Oats and the gluten-free diet. J Am Diet Assoc 103, 376-379.
70. Haboubi NY, Taylor S & Jones S (2006) Coeliac disease and oats: a systematic review. Postgrad Med J 82, 672-678.
71. Arentz-Hansen H, Fleckenstein B, Molberg O, et al. (2004) The molecular basis for oat intolerance in patients with celiac disease. PLoS Med 1, e1.
72. Thompson WG, Longstreth GF, Drossman DA, et al. (1999) Functional bowel disease and functional abdominal pain. Gut 45, 1143-1147.
73. Kojima M, Wakai K, Tokudome S, et al. (2004) Bowel movement frequency and risk of colorectal cancer in a large cohort study of Japanese men and women. Br J Cancer 90, 1397-1401.
74. Watanabe T, Nakaya N, Kurashima K, et al. (2004) Constipation, laxative use and risk of colorectal cancer: the Miyagi Cohort Study. Eur J Cancer 40, 2109-2115.
75. Park JY, Mitrou PN, Luben R, et al. (2009) Is bowel habit linked to colorectal cancer? - results from the EPIC-Norfolk study. Eur J Cancer 45, 139-145.
76. Simons CCJM, Schouten LJ, Weijenberg MP, et al. (2010) Bowel movement and constipation frequencies and the risk of colorectal cancer among men in the Netherlands Cohort Study on Diet and Cancer. Am J Epidemiol 172, 1404-1414.
77. Sengupta S, Muir JG & Gibson PR (2006) Does butyrate protect from colorectal cancer? J Gastroenterol Hepatol 21, 209-218.
78. Lupton JR (2004) Microbial degradation products influence colon cancer risk: the butyrate controversy. J Nutr 134, 479-482.
79. McBain JA, Eastman A, Nobel CS, et al. (1997) Apoptotic death in adenocarcinoma cell lines induced by butyrate and other histone deacetylase inhibitors. Biochem Pharmacol 53, 1357-1368.
80. Rouet-Benzineb P, Aparicio T, Guilmeau S, et al. (2004) Leptin counteracts sodium butyrate-induced apoptosis in human colon cancer HT-29 cells via NF-kappaB signaling. J Biol Chem 279, 495-502.
81. Andoh A, Tsujikawa T & Fujiyama Y (2003) Role of dietary fiber and short-chain fatty acids in the colon. Curr Pharm Des 9, 347-358.