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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 23, 2014, Pages 5450-5454

Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform

(15) Blackburn, Christopher a Barrett, Cynthia a Brunson, Mable a Chin, Janice a England, Dylan a Garcia, Kris a Gigstad, Kenneth a Gould, Alexandra a Gutierrez, Juan a Hoar, Kara a Rowland, R Scott a Tsu, Christopher a Ringeling, John a Wager, Krista a Xu, He a

a TAKEDA PHARMACEUTICAL COMPANY LIMITED (Japan)

Author keywords

Acetyl tubulin; HDAC6 selective; Histone deacetylase; Hydroxamic acid

Indexed keywords

1,2,3,4 TETRAHYDROPYRROLO[1,2 A]PYRAZINE; 1,2,3,4 TETRAHYDROPYRROLO[1,2 A]PYRAZINE HYDROXAMIC ACID; HETEROCYCLIC COMPOUND; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE 7; HISTONE DEACETYLASE 8; HISTONE DEACETYLASE INHIBITOR; PYRAZINE DERIVATIVE; TUBACIN; TUBASTATIN; UNCLASSIFIED DRUG; VORINOSTAT; HYDROXAMIC ACID; ISOPROTEIN;

APOPTOSIS; ARTICLE; CATALYST; CONTROLLED STUDY; CYCLOADDITION; DEACYLATION; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HELA CELL LINE; HISTONE ACETYLATION; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; ISOMERISM; PROTEIN DEGRADATION;

HISTONE DEACETYLASE INHIBITORS; HYDROXAMIC ACIDS; PROTEIN ISOFORMS; PYRAZINES;

EID: 84910120360 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.10.022 Document Type: Article

Times cited : (15)

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