Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N- hydroxybenzamide with high selectivity for the HDAC6 isoform

Journal of Medicinal Chemistry

Volumn 56, Issue 18, 2013, Pages 7201-7211

  Blackburn, Christopher ^a   Barrett, Cynthia ^a   Chin, Janice ^a   Garcia, Kris ^a   Gigstad, Kenneth ^a   Gould, Alexandra ^a   Gutierrez, Juan ^a   Harrison, Sean ^a   Hoar, Kara ^a   Lynch, Chrissie ^a   Rowland, R Scott ^a   Tsu, Chris ^a   Ringeling, John ^a   Xu, He ^a  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOHYDROXAMIC ACID; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE INHIBITOR; TRICHOSTATIN A; TUBACIN; VORINOSTAT;

ARTICLE; CAPPING PHENOMENON; CONTROLLED STUDY; DRUG DESIGN; DRUG INHIBITION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; FEMALE; HELA CELL; HUMAN; HUMAN CELL; HYDROPHOBICITY; IC 50;

BENZAMIDES; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; SUBSTRATE SPECIFICITY;

EID: 84885006253     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400385r     Document Type: Article

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