An electrostatic interaction at the tetrahelix bundle promotes phosphorylation-dependent cystic fibrosis transmembrane conductance regulator (CFTR) channel opening

Journal of Biological Chemistry

Volumn 289, Issue 44, 2014, Pages 30364-30378

  Wang, Wei ^a   Roessler, Bryan C ^a   Kirk, Kevin L ^a,b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHANNEL OPENING; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS;

ADENOSINE TRIPHOSPHATE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CFTR PROTEIN, HUMAN; GLUTAMIC ACID; LYSINE; PROTEIN BINDING;

ARTICLE; BINDING AFFINITY; BINDING SITE; CHANNEL GATING; CRYSTAL STRUCTURE; DIMERIZATION; GAIN OF FUNCTION MUTATION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN PHOSPHORYLATION; STATIC ELECTRICITY; CHEMISTRY; GENETICS; HEK293 CELL LINE; METABOLISM; MISSENSE MUTATION; PHOSPHORYLATION; PROTEIN DOMAIN; PROTEIN MULTIMERIZATION; PROTEIN PROCESSING; PROTEIN SECONDARY STRUCTURE;

ADENOSINE TRIPHOSPHATE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; GLUTAMIC ACID; HEK293 CELLS; HUMANS; ION CHANNEL GATING; LYSINE; MOLECULAR DYNAMICS SIMULATION; MUTATION, MISSENSE; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, SECONDARY;

EID: 84910093024     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.595710     Document Type: Article

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