Poly(l-histidine) based triblock copolymers: PH induced reassembly of copolymer micelles and mechanism underlying endolysosomal escape for intracellular delivery

Biomacromolecules

Volumn 15, Issue 11, 2014, Pages 4032-4045

  Zhang, Xiaojun ^a   Chen, Dawei ^a   Ba, Shuang ^a   Zhu, Jia ^a   Zhang, Jie ^a   Hong, Wei ^b   Zhao, Xiuli ^a   Hu, Haiyang ^a   Qiao, Mingxi ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SHENYANG AGRICULTURAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; COPOLYMERS; DRUG DELIVERY; DYNAMIC LIGHT SCATTERING; HYDROPHILICITY; HYDROPHOBICITY; MEMBRANES; MICELLES; MOTION PICTURE EXPERTS GROUP STANDARDS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARTICLE SIZE; POLYETHYLENE OXIDES; POLYOLS; SELF ASSEMBLY; TRANSMISSION ELECTRON MICROSCOPY;

AMPHIPHILIC CO-POLYMERS; CONFOCAL LASER SCAN MICROSCOPIES; DEGREES OF POLYMERIZATIONS; FLUORESCENCE PROBE TECHNIQUE; INTRACELLULAR DELIVERY; INTRACELLULAR DRUG DELIVERY; POLIES (LHISTIDINE); POLY (D ,L-LACTIDE);

POLYETHYLENE GLYCOLS;

COPOLYMER; DOXORUBICIN; MACROGOL; POLY(DEXTRO LEVO ACTIDE); POLY(LEVO HISTIDINE); UNCLASSIFIED DRUG; HISTIDINE; MICELLE; POLYHISTIDINE; POLYMER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CRITICAL MICELLE CONCENTRATION; DRUG DELIVERY SYSTEM; DRUG RELEASE; ENDOSOME; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR DRUG DELIVERY; IONIC STRENGTH; LIGHT SCATTERING; LYSOSOME MEMBRANE; MALE; MCF 7 CELL LINE; MICELLE; NONHUMAN; PARTICLE SIZE; PH; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; RAT; SUSTAINED DRUG RELEASE; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; CHEMISTRY; DRUG EFFECTS; INTRACELLULAR FLUID; LYSOSOME; METABOLISM; PROCEDURES; SPRAGUE DAWLEY RAT;

ANIMALS; DRUG DELIVERY SYSTEMS; HISTIDINE; HUMANS; HYDROGEN-ION CONCENTRATION; INTRACELLULAR FLUID; LYSOSOMES; MALE; MCF-7 CELLS; MICELLES; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84910055538     PISSN: 15257797     EISSN: 15264602     Source Type: Journal    
DOI: 10.1021/bm5010756     Document Type: Article

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