In vitro antitumor activity of methotrexate via pH-sensitive chitosan nanoparticles

Biomaterials

Volumn 34, Issue 11, 2013, Pages 2758-2772

  Nogueira, Daniele Rubert ^a   Tavano, Lorena ^b,c   Mitjans, Montserrat ^a,d   Pérez, Lourdes ^b   Infante, M Rosa ^b   Vinardell, M Pilar ^a,d  

^a UNIVERSITY OF BARCELONA   (Spain)

^b INSTITUTE OF ADVANCED CHEMISTRY OF CATALONIA IQAC CSIC   (Spain)

^c UNIVERSITY OF CALABRIA   (Italy)

^d CSIC   (Spain)

Author keywords

Chitosan nanoparticles; Cytotoxicity; Intracellular drug delivery; Lysine based surfactant; Methotrexate; PH sensitivity

Indexed keywords

ACIDIC ENVIRONMENT; ACIDIC MEDIUMS; ANTI-TUMOR ACTIVITIES; APOPTOTIC EFFECTS; CANCER CELLS; CANCER THERAPY; CARRIER SYSTEMS; CELL-CYCLE ARREST; CHITOSAN NANOPARTICLES; COMPLEXATION PROCESS; COUNTERIONS; CYTOSOLIC; IN-VITRO; INTRACELLULAR DRUG DELIVERY; MCF-7 CELLS; METHOTREXATE; PH SENSITIVE; PH-DEPENDENT ACTIVITY; PH-SENSITIVITY; TUMOR EXTRACELLULAR PH;

AMINO ACIDS; BIOTECHNOLOGY; CELL CULTURE; CHEMOTHERAPY; CHITOSAN; CYTOTOXICITY; DRUG DELIVERY; ENZYME ACTIVITY; LITHIUM; NANOPARTICLES; SURFACE ACTIVE AGENTS; TUMORS;

PH EFFECTS;

CHITOSAN DERIVATIVE; CHITOSAN NANOPARTICLE; LITHIUM; METHOTREXATE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOSOL; ENDOCYTOSIS; FEASIBILITY STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; LYSOSOME MEMBRANE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL;

ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; CELL CYCLE; CELL SURVIVAL; CHITOSAN; DRUG DELIVERY SYSTEMS; FEASIBILITY STUDIES; FLUORESCEINS; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; LYSINE; MCF-7 CELLS; METHOTREXATE; MICROSCOPY, FLUORESCENCE; NANOPARTICLES; PHYSICOCHEMICAL PHENOMENA; SURFACE-ACTIVE AGENTS;

EID: 84873082360     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.01.005     Document Type: Article

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