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Volumn 9, Issue 5, 2014, Pages 236-243

Drug/polymer nanoparticles prepared using unique spray nozzles and recent progress of inhaled formulation

Author keywords

Inhalation; Lung diseases; One step preparation of nanocomposite particles; Pulmonary drug delivery; Spray drying

Indexed keywords

DRUG; NANOCOMPOSITE; POLYMER; SMALL INTERFERING RNA; VACCINE;

EID: 84910029979     PISSN: 18180876     EISSN: 2221285X     Source Type: Journal    
DOI: 10.1016/j.ajps.2014.06.005     Document Type: Review
Times cited : (23)

References (52)
  • 1
    • 36749080982 scopus 로고    scopus 로고
    • The nanoscale in pulmonary delivery. Part 2: formulation platforms
    • Rogueda P.G., Traini D. The nanoscale in pulmonary delivery. Part 2: formulation platforms. Expert Opin Drug Deliv 2007, 4:607-620.
    • (2007) Expert Opin Drug Deliv , vol.4 , pp. 607-620
    • Rogueda, P.G.1    Traini, D.2
  • 2
    • 36649016656 scopus 로고    scopus 로고
    • The nanoscale in pulmonary delivery. Part 1: deposition, fate, toxicology and effects
    • Rogueda P.G., Traini D. The nanoscale in pulmonary delivery. Part 1: deposition, fate, toxicology and effects. Expert Opin Drug Deliv 2007, 4:595-606.
    • (2007) Expert Opin Drug Deliv , vol.4 , pp. 595-606
    • Rogueda, P.G.1    Traini, D.2
  • 3
    • 52049118554 scopus 로고    scopus 로고
    • What is the role of particle morphology in pharmaceutical powder aerosols?
    • Chan H.K. What is the role of particle morphology in pharmaceutical powder aerosols?. Expert Opin Drug Deliv 2008, 5:909-914.
    • (2008) Expert Opin Drug Deliv , vol.5 , pp. 909-914
    • Chan, H.K.1
  • 4
    • 25844477518 scopus 로고    scopus 로고
    • Preparation of two-drug composite microparticles to improve the dissolution of insoluble drug in water for use with a 4-fluid nozzle spray drier
    • Ozeki T., Beppu S., Mizoe T., et al. Preparation of two-drug composite microparticles to improve the dissolution of insoluble drug in water for use with a 4-fluid nozzle spray drier. J Control Release 2005, 107:387-394.
    • (2005) J Control Release , vol.107 , pp. 387-394
    • Ozeki, T.1    Beppu, S.2    Mizoe, T.3
  • 5
    • 32244438800 scopus 로고    scopus 로고
    • Preparation of polymeric submicron particle-containing microparticles using a 4-fluid nozzle spray drier
    • Ozeki T., Beppu S., Mizoe T., et al. Preparation of polymeric submicron particle-containing microparticles using a 4-fluid nozzle spray drier. Pharm Res 2006, 23:177-183.
    • (2006) Pharm Res , vol.23 , pp. 177-183
    • Ozeki, T.1    Beppu, S.2    Mizoe, T.3
  • 6
    • 57149143764 scopus 로고    scopus 로고
    • Application of a four-fluid nozzle spray drier to prepare inhalable rifampicin-containing mannitol microparticles
    • Mizoe T., Ozeki T., Okada H. Application of a four-fluid nozzle spray drier to prepare inhalable rifampicin-containing mannitol microparticles. AAPS Pharm Sci Tech 2008, 9:755-761.
    • (2008) AAPS Pharm Sci Tech , vol.9 , pp. 755-761
    • Mizoe, T.1    Ozeki, T.2    Okada, H.3
  • 7
    • 61649118970 scopus 로고    scopus 로고
    • One-step preparation of rifampicin/poly(lactic-co-glycolic acid) nanoparticle-containing mannitol microspheres using a four-fluid nozzle spray drier for inhalation therapy of tuberculosis
    • Ohashi K., Kabasawa T., Ozeki T., et al. One-step preparation of rifampicin/poly(lactic-co-glycolic acid) nanoparticle-containing mannitol microspheres using a four-fluid nozzle spray drier for inhalation therapy of tuberculosis. J Control Release 2009, 135:19-24.
    • (2009) J Control Release , vol.135 , pp. 19-24
    • Ohashi, K.1    Kabasawa, T.2    Ozeki, T.3
  • 8
    • 84869214168 scopus 로고    scopus 로고
    • Development of a novel and customizable two-solution mixing type spray nozzle for one-step preparation of nanoparticle-containing microparticles
    • Ozeki T., Akiyama Y., Takahashi N., et al. Development of a novel and customizable two-solution mixing type spray nozzle for one-step preparation of nanoparticle-containing microparticles. Biol Pharm Bull 2012, 35:1926-1931.
    • (2012) Biol Pharm Bull , vol.35 , pp. 1926-1931
    • Ozeki, T.1    Akiyama, Y.2    Takahashi, N.3
  • 9
    • 84866387096 scopus 로고    scopus 로고
    • Improved intestinal absorption of a poorly water-soluble oral drug using mannitol microparticles containing a nanosolid drug dispersion
    • Nishino Y., Kubota A., Kanazawa T., et al. Improved intestinal absorption of a poorly water-soluble oral drug using mannitol microparticles containing a nanosolid drug dispersion. J Pharm Sci 2012, 101:4191-4200.
    • (2012) J Pharm Sci , vol.101 , pp. 4191-4200
    • Nishino, Y.1    Kubota, A.2    Kanazawa, T.3
  • 11
    • 70350228508 scopus 로고    scopus 로고
    • Inhaled drug delivery for tuberculosis therapy
    • Muttil P., Wang C., Hickey A.J. Inhaled drug delivery for tuberculosis therapy. Pharm Res 2009, 26:2401-2416.
    • (2009) Pharm Res , vol.26 , pp. 2401-2416
    • Muttil, P.1    Wang, C.2    Hickey, A.J.3
  • 12
    • 84886513932 scopus 로고    scopus 로고
    • Pharmaceutical aerosols for the treatment and prevention of tuberculosis
    • Hanif S.N., Garcia-Contreras L. Pharmaceutical aerosols for the treatment and prevention of tuberculosis. Front Cell Infect Microbiol 2012, 2:118.
    • (2012) Front Cell Infect Microbiol , vol.2 , pp. 118
    • Hanif, S.N.1    Garcia-Contreras, L.2
  • 13
    • 79551498057 scopus 로고    scopus 로고
    • Inhaled drug therapy for treatment of tuberculosis
    • Misra A., Hickey A.J., Rossi C., et al. Inhaled drug therapy for treatment of tuberculosis. Tuberculosis (Edinb) 2011, 91:71-81.
    • (2011) Tuberculosis (Edinb) , vol.91 , pp. 71-81
    • Misra, A.1    Hickey, A.J.2    Rossi, C.3
  • 15
    • 77950101234 scopus 로고    scopus 로고
    • Dry powder PA-824 aerosols for treatment of tuberculosis in guinea pigs
    • Garcia-Contreras L., Sung J.C., Muttil P., et al. Dry powder PA-824 aerosols for treatment of tuberculosis in guinea pigs. Antimicrob Agents Chemother 2010, 54:1436-1442.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 1436-1442
    • Garcia-Contreras, L.1    Sung, J.C.2    Muttil, P.3
  • 16
    • 84864719781 scopus 로고    scopus 로고
    • Engineered PLGA nano- and micro-carriers for pulmonary delivery: challenges and promises
    • Ungaro F., d'Angelo I., Miro A., et al. Engineered PLGA nano- and micro-carriers for pulmonary delivery: challenges and promises. J Pharm Pharmacol 2012, 64:1217-1235.
    • (2012) J Pharm Pharmacol , vol.64 , pp. 1217-1235
    • Ungaro, F.1    d'Angelo, I.2    Miro, A.3
  • 17
    • 63649113410 scopus 로고    scopus 로고
    • Formation of inhalable rifampicin-poly(L-lactide) microparticles by supercritical anti-solvent process
    • Patomchaiviwat V., Paeratakul O., Kulvanich P. Formation of inhalable rifampicin-poly(L-lactide) microparticles by supercritical anti-solvent process. AAPS Pharm Sci Tech 2008, 9:1119-1129.
    • (2008) AAPS Pharm Sci Tech , vol.9 , pp. 1119-1129
    • Patomchaiviwat, V.1    Paeratakul, O.2    Kulvanich, P.3
  • 18
    • 0036260972 scopus 로고    scopus 로고
    • Multidrug resistance related molecules in human and murine lung
    • Scheffer G.L., Pijnenborg A.C., Smit E.F., et al. Multidrug resistance related molecules in human and murine lung. J Clin Pathol 2002, 55:332-339.
    • (2002) J Clin Pathol , vol.55 , pp. 332-339
    • Scheffer, G.L.1    Pijnenborg, A.C.2    Smit, E.F.3
  • 19
    • 67349255031 scopus 로고    scopus 로고
    • The use of biotinylated-EGF-modified gelatin nanoparticle carrier to enhance cisplatin accumulation in cancerous lungs via inhalation
    • Tseng C.L., Su W.Y., Yen K.C., et al. The use of biotinylated-EGF-modified gelatin nanoparticle carrier to enhance cisplatin accumulation in cancerous lungs via inhalation. Biomaterials 2009, 30:3476-3485.
    • (2009) Biomaterials , vol.30 , pp. 3476-3485
    • Tseng, C.L.1    Su, W.Y.2    Yen, K.C.3
  • 20
    • 82955207116 scopus 로고    scopus 로고
    • Aerosolized gemcitabine in patients with carcinoma of the lung: feasibility and safety study
    • Lemarie E., Vecellio L., Hureaux J., et al. Aerosolized gemcitabine in patients with carcinoma of the lung: feasibility and safety study. J Aerosol Med Pulm Drug Deliv 2011, 24:261-270.
    • (2011) J Aerosol Med Pulm Drug Deliv , vol.24 , pp. 261-270
    • Lemarie, E.1    Vecellio, L.2    Hureaux, J.3
  • 21
    • 43949144185 scopus 로고    scopus 로고
    • Pulmonary gemcitabine delivery for treating lung cancer: pharmacokinetics and acute lung injury aspects in animals
    • Min R., Li T., Du J., et al. Pulmonary gemcitabine delivery for treating lung cancer: pharmacokinetics and acute lung injury aspects in animals. Can J Physiol Pharmacol 2008, 86:288-298.
    • (2008) Can J Physiol Pharmacol , vol.86 , pp. 288-298
    • Min, R.1    Li, T.2    Du, J.3
  • 22
    • 77955449671 scopus 로고    scopus 로고
    • Aerosol gemcitabine: preclinical safety and invivo antitumor activity in osteosarcoma-bearing dogs
    • Rodriguez C.O., Crabbs T.A., Wilson D.W., et al. Aerosol gemcitabine: preclinical safety and invivo antitumor activity in osteosarcoma-bearing dogs. J Aerosol Med Pulm Drug Deliv 2010, 23:197-206.
    • (2010) J Aerosol Med Pulm Drug Deliv , vol.23 , pp. 197-206
    • Rodriguez, C.O.1    Crabbs, T.A.2    Wilson, D.W.3
  • 23
    • 84872944335 scopus 로고    scopus 로고
    • Design, physicochemical characterization, and optimization of organic solution advanced spray-dried inhalable dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylethanolamine poly(ethylene glycol) (DPPE-PEG) microparticles and nanoparticles for targeted respiratory nanomedicine delivery as dry powder inhalation aerosols
    • Meenach S.A., Vogt F.G., Anderson K.W., et al. Design, physicochemical characterization, and optimization of organic solution advanced spray-dried inhalable dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylethanolamine poly(ethylene glycol) (DPPE-PEG) microparticles and nanoparticles for targeted respiratory nanomedicine delivery as dry powder inhalation aerosols. Int J Nanomed 2013, 8:275-293.
    • (2013) Int J Nanomed , vol.8 , pp. 275-293
    • Meenach, S.A.1    Vogt, F.G.2    Anderson, K.W.3
  • 24
    • 84879470777 scopus 로고    scopus 로고
    • Characterization and aerosol dispersion performance of advanced spray-dried chemotherapeutic PEGylated phospholipid particles for dry powder inhalation delivery in lung cancer
    • Meenach S.A., Anderson K.W., Hilt J.Z., et al. Characterization and aerosol dispersion performance of advanced spray-dried chemotherapeutic PEGylated phospholipid particles for dry powder inhalation delivery in lung cancer. Eur J Pharm Sci 2013, 49:699-711.
    • (2013) Eur J Pharm Sci , vol.49 , pp. 699-711
    • Meenach, S.A.1    Anderson, K.W.2    Hilt, J.Z.3
  • 25
    • 79951942271 scopus 로고    scopus 로고
    • Inhalable nanoparticles, a non-invasive approach to treat lung cancer in a mouse model
    • Roa W.H., Azarmi S., Al-Hallak M.H., et al. Inhalable nanoparticles, a non-invasive approach to treat lung cancer in a mouse model. J Control Release 2011, 150:49-55.
    • (2011) J Control Release , vol.150 , pp. 49-55
    • Roa, W.H.1    Azarmi, S.2    Al-Hallak, M.H.3
  • 26
    • 84861834609 scopus 로고    scopus 로고
    • Distribution of effervescent inhalable nanoparticles after pulmonary delivery: an invivo study
    • Al-Hallak M.H., Sarfraz M.K., Azarmi S., et al. Distribution of effervescent inhalable nanoparticles after pulmonary delivery: an invivo study. Ther Deliv 2012, 3:725-734.
    • (2012) Ther Deliv , vol.3 , pp. 725-734
    • Al-Hallak, M.H.1    Sarfraz, M.K.2    Azarmi, S.3
  • 27
    • 77951011298 scopus 로고    scopus 로고
    • Phase I/II study of inhaled doxorubicin combined with platinum-based therapy for advanced non-small cell lung cancer
    • Otterson G.A., Villalona-Calero M.A., Hicks W. Phase I/II study of inhaled doxorubicin combined with platinum-based therapy for advanced non-small cell lung cancer. Clin Cancer Res 2010, 16:2466-2473.
    • (2010) Clin Cancer Res , vol.16 , pp. 2466-2473
    • Otterson, G.A.1    Villalona-Calero, M.A.2    Hicks, W.3
  • 28
    • 33947212925 scopus 로고    scopus 로고
    • Phase I study of inhaled doxorubicin for patients with metastatic tumors to the lungs
    • Otterson G.A., Villalona-Calero M.A., Sharma S., et al. Phase I study of inhaled doxorubicin for patients with metastatic tumors to the lungs. Clin Cancer Res 2007, 13:1246-1252.
    • (2007) Clin Cancer Res , vol.13 , pp. 1246-1252
    • Otterson, G.A.1    Villalona-Calero, M.A.2    Sharma, S.3
  • 29
    • 77953766334 scopus 로고    scopus 로고
    • Inhibition of lung tumor growth by complex pulmonary delivery of drugs with oligonucleotides as suppressors of cellular resistance
    • Garbuzenko O.B., Saad M., Pozharov V.P., et al. Inhibition of lung tumor growth by complex pulmonary delivery of drugs with oligonucleotides as suppressors of cellular resistance. Proc Natl Acad Sci U. S. a 2010, 107:10737-10742.
    • (2010) Proc Natl Acad Sci U. S. a , vol.107 , pp. 10737-10742
    • Garbuzenko, O.B.1    Saad, M.2    Pozharov, V.P.3
  • 30
    • 84865760040 scopus 로고    scopus 로고
    • Inhaled chemotherapy in lung cancer: future concept of nanomedicine
    • Zarogoulidis P., Chatzaki E., Porpodis K., et al. Inhaled chemotherapy in lung cancer: future concept of nanomedicine. Int J Nanomedicine 2012, 7:1551-1572.
    • (2012) Int J Nanomedicine , vol.7 , pp. 1551-1572
    • Zarogoulidis, P.1    Chatzaki, E.2    Porpodis, K.3
  • 31
    • 84877041363 scopus 로고    scopus 로고
    • Supercritical fluid technology based large porous celecoxib-PLGA microparticles do not induce pulmonary fibrosis and sustain drug delivery and efficacy for several weeks following a single dose
    • Dhanda D.S., Tyagi P., Mirvish S.S., et al. Supercritical fluid technology based large porous celecoxib-PLGA microparticles do not induce pulmonary fibrosis and sustain drug delivery and efficacy for several weeks following a single dose. J Control Release 2013, 168:239-250.
    • (2013) J Control Release , vol.168 , pp. 239-250
    • Dhanda, D.S.1    Tyagi, P.2    Mirvish, S.S.3
  • 33
    • 84877920804 scopus 로고    scopus 로고
    • New co-spray-dried tobramycin nanoparticles-clarithromycin inhaled powder systems for lung infection therapy in cystic fibrosis patients
    • Pilcer G., Rosiere R., Traina K., et al. New co-spray-dried tobramycin nanoparticles-clarithromycin inhaled powder systems for lung infection therapy in cystic fibrosis patients. J Pharm Sci 2013, 102:1836-1846.
    • (2013) J Pharm Sci , vol.102 , pp. 1836-1846
    • Pilcer, G.1    Rosiere, R.2    Traina, K.3
  • 34
    • 84875965687 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drug for pulmonary administration: design and investigation of ketoprofen lysinate fine dry powders
    • Stigliani M., Aquino R.P., Del Gaudio P., et al. Non-steroidal anti-inflammatory drug for pulmonary administration: design and investigation of ketoprofen lysinate fine dry powders. Int J Pharm 2013, 448:198-204.
    • (2013) Int J Pharm , vol.448 , pp. 198-204
    • Stigliani, M.1    Aquino, R.P.2    Del Gaudio, P.3
  • 35
    • 84881369362 scopus 로고    scopus 로고
    • Effect of polymers for aerolization properties of mannitol-based microcomposites containing meloxicam
    • Pomazi A., Buttini F., Ambrus R., et al. Effect of polymers for aerolization properties of mannitol-based microcomposites containing meloxicam. Eur Polym J 2013, 49:2518-2527.
    • (2013) Eur Polym J , vol.49 , pp. 2518-2527
    • Pomazi, A.1    Buttini, F.2    Ambrus, R.3
  • 36
    • 79957483467 scopus 로고    scopus 로고
    • Leucine enhances aerosol performance of naringin dry powder and its activity on cystic fibrosis airway epithelial cells
    • Prota L., Santoro A., Bifulco M., et al. Leucine enhances aerosol performance of naringin dry powder and its activity on cystic fibrosis airway epithelial cells. Int J Pharm 2011, 412:8-19.
    • (2011) Int J Pharm , vol.412 , pp. 8-19
    • Prota, L.1    Santoro, A.2    Bifulco, M.3
  • 37
    • 84872293534 scopus 로고    scopus 로고
    • Gentamicin and leucine inhalable powder: what about antipseudomonal activity and permeation through cystic fibrosis mucus?
    • Russo P., Stigliani M., Prota L., et al. Gentamicin and leucine inhalable powder: what about antipseudomonal activity and permeation through cystic fibrosis mucus?. Int J Pharm 2013, 440:250-255.
    • (2013) Int J Pharm , vol.440 , pp. 250-255
    • Russo, P.1    Stigliani, M.2    Prota, L.3
  • 38
    • 81255137213 scopus 로고    scopus 로고
    • Dry powders based on PLGA nanoparticles for pulmonary delivery of antibiotics: modulation of encapsulation efficiency, release rate and lung deposition pattern by hydrophilic polymers
    • Ungaro F., d'Angelo I., Coletta C., et al. Dry powders based on PLGA nanoparticles for pulmonary delivery of antibiotics: modulation of encapsulation efficiency, release rate and lung deposition pattern by hydrophilic polymers. J Control Release 2012, 157:149-159.
    • (2012) J Control Release , vol.157 , pp. 149-159
    • Ungaro, F.1    d'Angelo, I.2    Coletta, C.3
  • 39
    • 84873449341 scopus 로고    scopus 로고
    • Development of a dry, stable and inhalable acyl-homoserine-lactone-acylase powder formulation for the treatment of pulmonary Pseudomonas aeruginosa infections
    • Wahjudi M., Murugappan S., van Merkerk R., et al. Development of a dry, stable and inhalable acyl-homoserine-lactone-acylase powder formulation for the treatment of pulmonary Pseudomonas aeruginosa infections. Eur J Pharm Sci 2013, 48:637-643.
    • (2013) Eur J Pharm Sci , vol.48 , pp. 637-643
    • Wahjudi, M.1    Murugappan, S.2    van Merkerk, R.3
  • 40
    • 84870316205 scopus 로고    scopus 로고
    • New inhalation-optimized itraconazole nanoparticle-based dry powders for the treatment of invasive pulmonary aspergillosis
    • Duret C., Wauthoz N., Sebti T., et al. New inhalation-optimized itraconazole nanoparticle-based dry powders for the treatment of invasive pulmonary aspergillosis. Int J Nanomedicine 2012, 7:5475-5489.
    • (2012) Int J Nanomedicine , vol.7 , pp. 5475-5489
    • Duret, C.1    Wauthoz, N.2    Sebti, T.3
  • 41
    • 84859432248 scopus 로고    scopus 로고
    • Solid dispersions of itraconazole for inhalation with enhanced dissolution, solubility and dispersion properties
    • Duret C., Wauthoz N., Sebti T., et al. Solid dispersions of itraconazole for inhalation with enhanced dissolution, solubility and dispersion properties. Int J Pharm 2012, 428:103-113.
    • (2012) Int J Pharm , vol.428 , pp. 103-113
    • Duret, C.1    Wauthoz, N.2    Sebti, T.3
  • 42
    • 84865317556 scopus 로고    scopus 로고
    • Lipid-based carriers: manufacturing and applications for pulmonary route
    • Jaafar-Maalej C., Elaissari A., Fessi H. Lipid-based carriers: manufacturing and applications for pulmonary route. Expert Opin Drug Deliv 2012, 9:1111-1127.
    • (2012) Expert Opin Drug Deliv , vol.9 , pp. 1111-1127
    • Jaafar-Maalej, C.1    Elaissari, A.2    Fessi, H.3
  • 43
    • 85009520370 scopus 로고    scopus 로고
    • Pulmonary disposition of vancomycin nebulized as lipid vesicles in rats
    • de Jesus valle M.J., Garavis Gozalez J., Lopez F.G., et al. Pulmonary disposition of vancomycin nebulized as lipid vesicles in rats. J Antibiot 2013, 1-5.
    • (2013) J Antibiot , pp. 1-5
    • de Jesus valle, M.J.1    Garavis Gozalez, J.2    Lopez, F.G.3
  • 44
    • 34247205938 scopus 로고    scopus 로고
    • Pulmonary vaccine delivery
    • Lu D., Hickey A.J. Pulmonary vaccine delivery. Expert Rev Vaccines 2007, 6:213-226.
    • (2007) Expert Rev Vaccines , vol.6 , pp. 213-226
    • Lu, D.1    Hickey, A.J.2
  • 45
    • 84891484003 scopus 로고    scopus 로고
    • Inhaled vaccines for the prevention of tuberculosis
    • an open access journal
    • Garcia-Contreras L., Awashthi S., Hanif S.N.M., et al. Inhaled vaccines for the prevention of tuberculosis. J Mycobac Dis 2012, an open access journal (ISSN: 2161-1068). 10.4172/2161-1068.S1-002.
    • (2012) J Mycobac Dis
    • Garcia-Contreras, L.1    Awashthi, S.2    Hanif, S.N.M.3
  • 47
    • 77953028098 scopus 로고    scopus 로고
    • Influenza virus-like particles as an antigen-carrier platform for the ESAT-6 epitope of Mycobacterium tuberculosis
    • Krammer F., Schinko T., Messner P., et al. Influenza virus-like particles as an antigen-carrier platform for the ESAT-6 epitope of Mycobacterium tuberculosis. J Virol Methods 2010, 167:17-22.
    • (2010) J Virol Methods , vol.167 , pp. 17-22
    • Krammer, F.1    Schinko, T.2    Messner, P.3
  • 48
    • 84879121471 scopus 로고    scopus 로고
    • Feasibility of spray drying bacteriophages into respirable powders to combat pulmonary bacterial infections
    • Vandenheuvel D., Singh A., Vandersteegen K., et al. Feasibility of spray drying bacteriophages into respirable powders to combat pulmonary bacterial infections. Eur J Pharm Biopharm 2013, 84:578-582.
    • (2013) Eur J Pharm Biopharm , vol.84 , pp. 578-582
    • Vandenheuvel, D.1    Singh, A.2    Vandersteegen, K.3
  • 50
    • 77955937531 scopus 로고    scopus 로고
    • Pulmonary immunization using antigen 85-B polymeric microparticles to boost tuberculosis immunity
    • Lu D., Garcia-Contreras L., Muttil P., et al. Pulmonary immunization using antigen 85-B polymeric microparticles to boost tuberculosis immunity. Aaps J 2010, 12:338-347.
    • (2010) Aaps J , vol.12 , pp. 338-347
    • Lu, D.1    Garcia-Contreras, L.2    Muttil, P.3
  • 51
    • 67349275745 scopus 로고    scopus 로고
    • Pulmonary delivery of DNA encoding Mycobacterium tuberculosis latency antigen Rv1733c associated to PLGA-PEI nanoparticles enhances T cell responses in a DNA prime/protein boost vaccination regimen in mice
    • Bivas-Benita M., Lin M.Y., Bal S.M., et al. Pulmonary delivery of DNA encoding Mycobacterium tuberculosis latency antigen Rv1733c associated to PLGA-PEI nanoparticles enhances T cell responses in a DNA prime/protein boost vaccination regimen in mice. Vaccine 2009, 27:4010-4017.
    • (2009) Vaccine , vol.27 , pp. 4010-4017
    • Bivas-Benita, M.1    Lin, M.Y.2    Bal, S.M.3
  • 52


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