Pulmonary immunization using antigen 85-b polymeric microparticles to boost tuberculosis immunity

AAPS Journal

Volumn 12, Issue 3, 2010, Pages 338-347

  Lu, Dongmei ^a,d   Garcia Contreras, Lucila ^a   Muttil, Pavan ^a   Padilla, Danielle ^a,e   Xu, Ding ^a   Liu, Jian ^a   Braunstein, Miriam ^b   McMurray, David N ^c   Hickey, Anthony James ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^d PFIZER INC   (United States)

^e U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

antigen 85B; BCG; boost immunization; microparticles; pulmonary delivery

Indexed keywords

BCG VACCINE; POLYGLACTIN; RECOMBINANT ANTIGEN; RECOMBINANT ANTIGEN 85B; UNCLASSIFIED DRUG; AEROSOL; BACTERIAL ANTIGEN; LACTIC ACID; MICROSPHERE; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; RECOMBINANT PROTEIN;

AERATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COUNT; COLONY FORMING UNIT; CONTROLLED STUDY; DRUG EFFICACY; DRUG FORMULATION; DRY POWDER; ESCHERICHIA COLI; GRANULOMA; GUINEA PIG; HETEROLOGOUS EXPRESSION; HISTOPATHOLOGY; IMMUNITY; IMMUNIZATION; LUNG PARENCHYMA; LUNG TUBERCULOSIS; MICROENCAPSULATION; MORPHOMETRICS; MULTIPLE DRUG DOSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTECTION; SINGLE DRUG DOSE; SPLEEN; AEROSOL; ANIMAL; DELAYED HYPERSENSITIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOLOGY; LUNG; TUBERCULOSIS;

AEROSOLS; ANIMALS; ANTIGENS, BACTERIAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GUINEA PIGS; HYPERSENSITIVITY, DELAYED; LACTIC ACID; LUNG; MICROSPHERES; MYCOBACTERIUM TUBERCULOSIS; POLYGLYCOLIC ACID; RECOMBINANT PROTEINS; TUBERCULOSIS;

EID: 77955937531     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-010-9193-1     Document Type: Article

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