Formation of inhalable rifampicin-poly(l-lactide) microparticles by supercritical anti-solvent process

AAPS PharmSciTech

Volumn 9, Issue 4, 2008, Pages 1119-1129

  Patomchaiviwat, Vipaluk ^a   Paeratakul, Ornlaksana ^b   Kulvanich, Poj ^a  

^a CHULALONGKORN UNIVERSITY   (Thailand)

^b SRINAKHARINWIROT UNIVERSITY   (Thailand)

Author keywords

Biodegradable; Inhalation; Microparticles; Poly(L lactide); Rifampicin; Supercritical anti solvent

Indexed keywords

CARBON DIOXIDE; DICHLOROMETHANE; POLYLACTIDE; RIFAMPICIN; MICROSPHERE; POLYESTER; SOLVENT;

AEROSOL; ARTICLE; DRUG RELEASE; DRY POWDER; PARTICLE SIZE; PRESSURE; PROCESS DESIGN; SUPERCRITICAL FLUID; TEMPERATURE; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INHALATIONAL DRUG ADMINISTRATION; SCANNING ELECTRON MICROSCOPY;

ADMINISTRATION, INHALATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; POLYESTERS; RIFAMPIN; SOLVENTS;

EID: 63649113410     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-008-9152-7     Document Type: Article

References (37)

1. L. Goodman, and A. Gillman. The pharmacological basis of pharmaceutics, Macmillan, New York, 1970, pp. 1208-1210.
2. P. Deol, G. K. Khuller, and K. Joshi. Therapeutic efficacies of isoniazid and rifampicin encapsulated in lung specific stealth liposomes against Mycobacterium tuberculosis infection induced in mice. Antimicrob. Agents Chemother. 41:1211-1214 (1997).
3. D. C. Quenelle, J. K. Staas, G. A. Winchester, E. L. Barrow, and W. W. Barrow. Efficacy of microencapsulated rifampin in Mycobacterium tuberculosis -infected mice. Antimicrob. Agents Chemother. 43:1144-1151 (1999).
4. E. Barrow, G. Winchester, J. Staas, D. Quenelle, and W. Barrow. Use of microsphere technology for targeted delivery of rifampin to Mycobacterium tuberculosis -infected macrophages. Antimicrob. Agents Chemother. 42:2682-2689 (1998).
5. A. Hickey, S. Suarez, M. Bhat, P. Hara, C. Lalor, K. Atkins, R. Hopfer, and D. McMurray. Efficacy of rifampicin-poly (lactide-co-glycolide) microspheres in treating tuberculosis. RDD IV 201-209 (1998).
6. P. O'Hara, and A. J. Hickey. Respirable PLGA microspheres containing rifampicin for the treatment of tuberculosis: Manufacture and characterization. Pharm. Res. 17: 955-961 (2000).
7. S. Suarez, P. O'Hara, M. Kazantseva, C. E. Newcomer, R. Hopfer, D. N. McMurray, and A. J. Hickey. Respirable PLGA microspheres containing rifampicin for the treatment of tuberculosis: Screening in an infectious disease model. Pharm. Res. 189:1315-1319 (2001).
8. I. Coowanitwong, V. Arya, P. Kulvanivh, and G. (2008). Hochhaus. Slow release formulation of inhaled rifampicin. AAPS J., published online. doi: 10.1028/s12248-008-9044-5.
9. D. L. Biggs, C. S. Lengsfeld, B. M. Hybertson, K.-Y. Ng, M. C. Manning, and T. W. Randolph. In vitro and in vivo evaluation of the effects of PLA microparticle crystallinity on cellular response. J. Control. Release. 92:147-161 (2003).
10. W. C. Hinds. Aerosol technology: Properties, behavior, and measurement of airborne particles, Wiley, New York, 1982, p. 424.
11. M. Bahrami, and S. Ranjbarian. Production of micro- and nano-composite particles by supercritical carbon dioxide. J. Supercritical Fluids. 40:263-283 (2007).
12. J. W. Tom, and P. G. Debenedetti. Particle formation with supercritical fluids - a review. J. Aerosol Sci. 22:555-584 (1991).
13. E. M. Philips, and V. J. Stella. Rapid expansion from supercritical solutions: Application to pharmaceutical processes. Int. J. Pharm. 94:1-10 (1993).
14. P. G. Debenedetti, J. W. Tom, S. D. Yeo, and G. B. Lim. Application of supercritical fluids for production of sustained delivery devices. J. Control. Release. 24:27-44 (1993).
15. J. W. Tom, G. B. Lim, P. G. Debenedetti, and R. K. Prud'homme. Applications of supercritical fluids in the controlled release of drugs. In E. Kiran, and J. F. Brennecke (eds.), Supercritical Fluid Engineering Science: Fundamentals and Applications ACS Symposium Series 514, American Chemical Society, Washington DC, 1993, pp. 238-257.
16. S. D. Yeo, G. B. Lim, and P. G. Debenedetti. Formation of microparticulate protein powders using a supercritical fluid anti-solvent. Biotechnol. Bioeng. 41:341-346 (1993).
17. F. Ruchatz, P. Kleinebudde, and B. W. Muller. Residual solvents in biodegradable microparticles: Influence of process parameters on the residual solvent in microparticles produced by the aerosol solvent extraction system (ASES) process. J. Pharm. Sci. 86:101-105 (1997).
18. I. Pasquali, R. Bettini, and F. Giordano. Supercritical fluid technologies: An innovative approach for manipulating the solid-state of pharmaceuticals. Adv. Drug Deliv. Rev. 60:399-410 (2008).
19. J. Bleich, B. W. Muller, and W. Wabrnus. Aerosol system extraction system - a new microparticle production technique. Int. J. Pharm. 97: 111-117 (1993).
20. T. W. Randolph, A. D. Randolph, M. Mebes, and S. Yeung. Sub-micrometer-sized biodegradable particles of poly (l-lactic acid) via the gas antisolvent spray precipitation process. Biotechnol. Prog. 9:429-435 (1993).
21. Y. M. Kim, Y. W. Lee, H.-S. Byun, and S. Lim Jong. Recrystallization of poly(L-lactic acid) into submicrometer particles in supercritical carbon dioxide. Ind. Eng. Chem. Res. 45: 3388-3392 (2006).
22. E. Reverchon, G. Della Porta, I. De Rosa, P. Subra, and D. Letourneur. Supercritical antisolvent micronization of some biopolymers. J. Supercrit. Fluids. 18: 239-245 (2000).
23. E. Reverchon, and G. Della Porta. Production of antibiotic micro- and nano-particles by supercritical antisolvent precipitation. Powder Technol. 106: 23-29 (1999).
24. E. Reverchon, and I. De Marco. Supercritical antisolvent precipitation of cephalosporins. Powder Technol. 164: 139-146 (2006).
25. E. Reverchon, I. De Marco, and G. Della Porta. Rifampicin microparticles production by supercritical antisolvent precipitation. Int. J. Pharm. 243: 83-91 (2002).
26. A. Tandya, R. Mammucaria, F. Dehghani, and N. R. Foster. Dense gas processing of polymeric controlled release formulations. Int. J. Pharm. 328: 1-11 (2007).
27. J. D. Meyer et al. Preparation and in vitro characterization of gentamicin-impregnated bio-degradable beads suitable for treatment of osteomyelitis. J. Pharm. Sci. 87: 1149-1154 (1998).
28. R. Ghaderi, P. Artursson, and J. Carlfors. A new method for preparing biodegradable microparticles and entrapment of hydrocortisone in DL-PLG microparticles using supercritical fluids. Eur. J. Pharm. Sci. 10:1-9 (2000).
29. C. Bitz, and E. Doelker. Influence of the preparation method on residual solvents in biodegradable microspheres. Int. J. Pharm. 131: 171-181 (1996).
30. H. Steckel, J. Thies, and B. W. Muller. Micronizing of steroids for pulmonary delivery by supercritical carbon dioxide. Int. J. Pharm. 152: 99-110 (1997).
31. E. Reverchon, and G. Della Porta. Terbutaline microparticles suitable for aerosol delivery produced by supercritical assisted atomization. Int. J. Pharm. 258: 1-9 (2003).
32. Y. H. Kim, and K. S. Shing. Supercritical fluid-micronized ipratropium bromide for pulmonary drug delivery. Powder Technol. 182: 25-32 (2008).
33. R. Panchagnula, A. Sood, N. Sharda, K. Kaur, and C. L. Kaul. Determination of rifampicin and its main metabolite in plasma and urine in presence of pyrazinamide and isoniazid by HPLC method. J. Pharm. Biomed. Anal. 18: 1013-1020 (1999).
34. L. Tu, F. Dehghani, and N. R. Foster. Micronisation and microencapsulation of pharmaceuticals using a carbon dioxide antisolvent. Powder Technol. 126:134-149 (2002).
35. R. Bodmeier, H. Wang, D. J. Dixon, S. Mawson, and K. P. Johnston. Polymeric microspheres prepared by spray into compressed carbon dioxide. Pharm. Res. 12: 1211-1217 (1995).
36. D. J. Dixon, K. P. Johnston, and R. A. Bodmeier. Polymeric materials formed by precipitation with a compressed fluid antisolvent. AIChE J. 391:127-139(1993).
37. J. Bleich, P. Kleinebudde, and B. W. Muller. Influence of gas density and pressure on microparticles produced with the ASES process. Int. J. Pharm. 106:77- 84 (1994).