메뉴 건너뛰기




Volumn 23, Issue 4, 2010, Pages 197-206

Aerosol gemcitabine: Preclinical safety and in vivo antitumor activity in osteosarcoma-bearing dogs

Author keywords

aerosol chemotherapy; dog model; gemcitabine; relapsed osteosarcoma

Indexed keywords

FAS ANTIGEN; GEMCITABINE;

EID: 77955449671     PISSN: 19412711     EISSN: 19412703     Source Type: Journal    
DOI: 10.1089/jamp.2009.0773     Document Type: Article
Times cited : (34)

References (57)
  • 2
    • 18044364798 scopus 로고    scopus 로고
    • Overview of sarcomas in the adolescent and young adult population
    • Herzog CE: Overview of sarcomas in the adolescent and young adult population. J Pediatr Hematol Oncol. 2005; 27:215 218.
    • (2005) J Pediatr Hematol Oncol , vol.27 , pp. 215-218
    • Herzog, C.E.1
  • 4
    • 33746607711 scopus 로고    scopus 로고
    • Osteosarcoma relapse: Expect the worst, but hope for the best
    • Anderson P: Osteosarcoma relapse: expect the worst, but hope for the best. Pediatr Blood Cancer. 2006;47:231.
    • (2006) Pediatr Blood Cancer , vol.47 , pp. 231
    • Anderson, P.1
  • 6
    • 0345707586 scopus 로고    scopus 로고
    • Pattern of disease recurrence and prognostic factors in patients with osteosarcoma treated with contemporary chemotherapy
    • Hawkins DS, Arndt CA: Pattern of disease recurrence and prognostic factors in patients with osteosarcoma treated with contemporary chemotherapy. Cancer. 2003;98:2447-2456.
    • (2003) Cancer , vol.98 , pp. 2447-2456
    • Hawkins, D.S.1    Arndt, C.A.2
  • 7
    • 0024102290 scopus 로고
    • Canine osteosarcoma. Treatment by amputation versus amputation and adjuvant chemotherapy using doxorubicin and cisplatin
    • Mauldin GN, Matus RE, Withrow SJ, Patnaik AK: Canine osteosarcoma. Treatment by amputation versus amputation and adjuvant chemotherapy using doxorubicin and cisplatin. J Vet Intern Med. 1988;2:177-180.
    • (1988) J Vet Intern Med , vol.2 , pp. 177-180
    • Mauldin, G.N.1    Matus, R.E.2    Withrow, S.J.3    Patnaik, A.K.4
  • 10
    • 0030022335 scopus 로고    scopus 로고
    • Canine osteosarcoma: Amputation and chemotherapy
    • Berg J: Canine osteosarcoma: amputation and chemotherapy. Vet Clin North Am Small Anim Pract. 1996;26:111-121.
    • (1996) Vet Clin North Am Small Anim Pract , vol.26 , pp. 111-121
    • Berg, J.1
  • 12
    • 0025946127 scopus 로고    scopus 로고
    • Osteogenic sarcoma and cisplatin chemotherapy in dogs: 16 cases (1986-1989)
    • Kraegel SA, Madewell BR, Simonson E, Gregory CR: Osteogenic sarcoma and cisplatin chemotherapy in dogs: 16 cases (1986-1989). J Am Vet Med Assoc. 1991;199:1057-1059.
    • J Am Vet Med Assoc. , vol.1991 , Issue.199 , pp. 1057-1059
    • Kraegel, S.A.1    Madewell, B.R.2    Simonson, E.3    Gregory, C.R.4
  • 13
    • 0017834317 scopus 로고
    • Amputation and doxorubicin for treatment of canine and feline osteogenic sarcoma
    • Madewell BR, Leighton RL, Theilen GH: Amputation and doxorubicin for treatment of canine and feline osteogenic sarcoma. Eur J Cancer. 1978;14:287-293.
    • (1978) Eur J Cancer , vol.14 , pp. 287-293
    • Madewell, B.R.1    Leighton, R.L.2    Theilen, G.H.3
  • 14
    • 0026575299 scopus 로고    scopus 로고
    • Evaluation of survival times after limb amputation, with and without subsequent administration of cisplatin, for treatment of appendicular osteosarcoma in dogs: 30 cases (1979-1990)
    • Thompson JP, Fugent MJ: Evaluation of survival times after limb amputation, with and without subsequent administration of cisplatin, for treatment of appendicular osteosarcoma in dogs: 30 cases (1979-1990). J Am Vet Med Assoc. 1992;200:531-533.
    • J Am Vet Med Assoc. , vol.1992 , Issue.200 , pp. 531-533
    • Thompson, J.P.1    Fugent, M.J.2
  • 15
    • 0029012086 scopus 로고
    • Results of surgery and doxorubicin chemotherapy in dogs with osteosarcoma
    • Berg J, Weinstein MJ, Springfield DS, Rand WM: Results of surgery and doxorubicin chemotherapy in dogs with osteosarcoma. J Am Vet Med Assoc. 1995;206:1555-1560.
    • (1995) J Am Vet Med Assoc , vol.206 , pp. 1555-1560
    • Berg, J.1    Weinstein, M.J.2    Springfield, D.S.3    Rand, W.M.4
  • 18
    • 0028033227 scopus 로고
    • Single-agent activity of weekly gemcitabine in advanced non-small-cell lung cancer: A phase II study
    • Anderson H, Lund B, Bach F, Thatcher N, Walling J, Hansen HH: Single-agent activity of weekly gemcitabine in advanced non-small-cell lung cancer: a phase II study. J Clin Oncol. 1994;12:1821-1826.
    • (1994) J Clin Oncol , vol.12 , pp. 1821-1826
    • Anderson, H.1    Lund, B.2    Bach, F.3    Thatcher, N.4    Walling, J.5    Hansen, H.H.6
  • 22
    • 0030915362 scopus 로고    scopus 로고
    • Gemcitabine: Future prospects of single-agent and combination studies
    • van Moorsel CJ, Peters GJ, Pinedo HM: Gemcitabine: Future prospects of single-agent and combination studies. Oncologist. 1997;2:127-134.
    • (1997) Oncologist , vol.2 , pp. 127-134
    • Van Moorsel, C.J.1    Peters, G.J.2    Pinedo, H.M.3
  • 25
    • 0036467995 scopus 로고    scopus 로고
    • Prolonged infusion of gemcitabine: Clinical and pharmacodynamic studies during a phase i trial in relapsed acute myelogenous leukemia
    • Gandhi V, Plunkett W, Du M, Ayres M, Estey EH: Prolonged infusion of gemcitabine: clinical and pharmacodynamic studies during a phase I trial in relapsed acute myelogenous leukemia. J Clin Oncol. 2002;20:665-673.
    • (2002) J Clin Oncol , vol.20 , pp. 665-673
    • Gandhi, V.1    Plunkett, W.2    Du, M.3    Ayres, M.4    Estey, E.H.5
  • 28
    • 0141731181 scopus 로고    scopus 로고
    • Gemcitabine as a radiosensitizer for nonresectable feline oral squamous cell carcinoma
    • Jones PD, de Lorimier LP, Kitchell BE, Losonsky JM: Gemcitabine as a radiosensitizer for nonresectable feline oral squamous cell carcinoma. J Am Anim Hosp Assoc. 2003;39: 463-467.
    • (2003) J Am Anim Hosp Assoc , vol.39 , pp. 463-467
    • Jones, P.D.1    De Lorimier, L.P.2    Kitchell, B.E.3    Losonsky, J.M.4
  • 29
    • 13544269471 scopus 로고    scopus 로고
    • Clinical evaluation of gemcitabine in dogs with spontaneously occurring malignancies
    • Kosarek CE, Kisseberth WC, Gallant SL, Couto CG: Clinical evaluation of gemcitabine in dogs with spontaneously occurring malignancies. J Vet Intern Med. 2005;19:81-86.
    • (2005) J Vet Intern Med , vol.19 , pp. 81-86
    • Kosarek, C.E.1    Kisseberth, W.C.2    Gallant, S.L.3    Couto, C.G.4
  • 30
    • 7244221409 scopus 로고    scopus 로고
    • Unexpected toxicity following use of gemcitabine as a radiosensitizer in head and neck carcinomas: A veterinary radiation therapy oncology group pilot study
    • LeBlanc AK, LaDue TA, Turrel JM, Klein MK: Unexpected toxicity following use of gemcitabine as a radiosensitizer in head and neck carcinomas: a veterinary radiation therapy oncology group pilot study. Vet Radiol Ultrasound. 2004;45:466-470.
    • (2004) Vet Radiol Ultrasound , vol.45 , pp. 466-470
    • Leblanc, A.K.1    Ladue, T.A.2    Turrel, J.M.3    Klein, M.K.4
  • 32
    • 33644681751 scopus 로고    scopus 로고
    • Pharmacokinetics of gemcitabine and its primary metabolite in dogs after intravenous infusion
    • Freise KJ, Martin-Jimenez T: Pharmacokinetics of gemcitabine and its primary metabolite in dogs after intravenous infusion. J Vet Pharmacol Ther. 2006;29:147-152.
    • (2006) J Vet Pharmacol Ther , vol.29 , pp. 147-152
    • Freise, K.J.1    Martin-Jimenez, T.2
  • 33
    • 33644663834 scopus 로고    scopus 로고
    • Pharmacokinetics of gemcitabine and its primary metabolite in dogs after intravenous bolus dosing and its in vitro pharmacodynamics
    • Freise KJ, Martin-Jimenez T: Pharmacokinetics of gemcitabine and its primary metabolite in dogs after intravenous bolus dosing and its in vitro pharmacodynamics. J Vet Pharmacol Ther. 2006;29:137-145.
    • (2006) J Vet Pharmacol Ther , vol.29 , pp. 137-145
    • Freise, K.J.1    Martin-Jimenez, T.2
  • 34
    • 21844479544 scopus 로고    scopus 로고
    • Gemcitabine inhibits viability, growth, and metastasis of osteosarcoma cell lines
    • Ando T, Ichikawa J, Okamoto A, Tasaka K, Nakao A, Hamada Y: Gemcitabine inhibits viability, growth, and metastasis of osteosarcoma cell lines. J Orthop Res. 2005;23: 964-969.
    • (2005) J Orthop Res , vol.23 , pp. 964-969
    • Ando, T.1    Ichikawa, J.2    Okamoto, A.3    Tasaka, K.4    Nakao, A.5    Hamada, Y.6
  • 36
    • 25844511183 scopus 로고    scopus 로고
    • Combination of gemcitabine and irinotecan for recurrent metastatic osteogenic sarcoma
    • 300-302
    • Zak D, Styler MJ, Rosenbluth JZ, Brodsky I: Combination of gemcitabine and irinotecan for recurrent metastatic osteogenic sarcoma. Clin Adv Hematol Oncol. 2005;3:297-299; discussion 300-302.
    • (2005) Clin Adv Hematol Oncol , vol.3 , pp. 297-299
    • Zak, D.1    Styler, M.J.2    Rosenbluth, J.Z.3    Brodsky, I.4
  • 38
    • 0032127135 scopus 로고    scopus 로고
    • Palliative effect of gemcitabine in osteosarcoma resistant to standard chemotherapy
    • Merimsky O, Meller I, Kollender Y, Inbar M: Palliative effect of gemcitabine in osteosarcoma resistant to standard chemotherapy. Eur J Cancer. 1998;34:1296-1297.
    • (1998) Eur J Cancer , vol.34 , pp. 1296-1297
    • Merimsky, O.1    Meller, I.2    Kollender, Y.3    Inbar, M.4
  • 40
    • 48249154929 scopus 로고    scopus 로고
    • Combination of gemcitabine and docetaxel in the treatment of children and young adults with refractory bone sarcoma
    • Navid F, Willert JR, McCarville MB, Furman W, Watkins A, Roberts W, Daw NC: Combination of gemcitabine and docetaxel in the treatment of children and young adults with refractory bone sarcoma. Cancer. 2008;113:419-425.
    • (2008) Cancer , vol.113 , pp. 419-425
    • Navid, F.1    Willert, J.R.2    McCarville, M.B.3    Furman, W.4    Watkins, A.5    Roberts, W.6    Daw, N.C.7
  • 41
    • 34547686124 scopus 로고    scopus 로고
    • Corruption of the Fas pathway delays the pulmonary clearance of murine osteosarcoma cells, enhances their metastatic potential, and reduces the effect of aerosol gemcitabine
    • Gordon N, Koshkina NV, Jia SF, Khanna C, Mendoza A, Worth LL, Kleinerman ES: Corruption of the Fas pathway delays the pulmonary clearance of murine osteosarcoma cells, enhances their metastatic potential, and reduces the effect of aerosol gemcitabine. Clin Cancer Res. 2007;13:4503-4510.
    • (2007) Clin Cancer Res , vol.13 , pp. 4503-4510
    • Gordon, N.1    Koshkina, N.V.2    Jia, S.F.3    Khanna, C.4    Mendoza, A.5    Worth, L.L.6    Kleinerman, E.S.7
  • 42
    • 22244439824 scopus 로고    scopus 로고
    • Aerosol gemcitabine inhibits the growth of primary osteosarcoma and osteosarcoma lung metastases
    • Koshkina NV, Kleinerman ES: Aerosol gemcitabine inhibits the growth of primary osteosarcoma and osteosarcoma lung metastases. Int J Cancer. 2005;116:458-463.
    • (2005) Int J Cancer , vol.116 , pp. 458-463
    • Koshkina, N.V.1    Kleinerman, E.S.2
  • 44
    • 0029912238 scopus 로고    scopus 로고
    • Aerosol delivery of interleukin 2 liposomes is nontoxic and biologically effective: Canine studies
    • Khanna C, Hasz DE, Klausner JS, Anderson PM: Aerosol delivery of interleukin 2 liposomes is nontoxic and biologically effective: canine studies. Clin Cancer Res. 1996;2:721-734.
    • (1996) Clin Cancer Res , vol.2 , pp. 721-734
    • Khanna, C.1    Hasz, D.E.2    Klausner, J.S.3    Anderson, P.M.4
  • 46
    • 0032853556 scopus 로고    scopus 로고
    • Inhalation chemotherapy for macroscopic primary or metastatic lung tumors: Proof of principle using dogs with spontaneously occurring tumors as a model
    • Hershey AE, Kurzman ID, Forrest LJ, Bohling CA, Stonerook M, Placke ME, Imondi AR, Vail DM: Inhalation chemotherapy for macroscopic primary or metastatic lung tumors: proof of principle using dogs with spontaneously occurring tumors as a model. Clin Cancer Res. 1999;5:2653-2659.
    • (1999) Clin Cancer Res , vol.5 , pp. 2653-2659
    • Hershey, A.E.1    Kurzman, I.D.2    Forrest, L.J.3    Bohling, C.A.4    Stonerook, M.5    Placke, M.E.6    Imondi, A.R.7    Vail, D.M.8
  • 47
    • 0034787791 scopus 로고    scopus 로고
    • Paclitaxel liposome aerosol treatment induces inhibition of pulmonary metastases in murine renal carcinoma model
    • Koshkina NV, Waldrep JC, Roberts LE, Golunski E, Melton S, Knight V: Paclitaxel liposome aerosol treatment induces inhibition of pulmonary metastases in murine renal carcinoma model. Clin Cancer Res. 2001;7:3258-3262.
    • (2001) Clin Cancer Res , vol.7 , pp. 3258-3262
    • Koshkina, N.V.1    Waldrep, J.C.2    Roberts, L.E.3    Golunski, E.4    Melton, S.5    Knight, V.6
  • 49
    • 35948951989 scopus 로고    scopus 로고
    • Fas-negative osteosarcoma tumor cells are selected during metastasis to the lungs: The role of the Fas pathway in the metastatic process of osteosarcoma
    • Koshkina NV, Khanna C, Mendoza A, Guan H, DeLauter L, Kleinerman ES: Fas-negative osteosarcoma tumor cells are selected during metastasis to the lungs: the role of the Fas pathway in the metastatic process of osteosarcoma. Mol Cancer Res. 2007;5:991-999.
    • (2007) Mol Cancer Res , vol.5 , pp. 991-999
    • Koshkina, N.V.1    Khanna, C.2    Mendoza, A.3    Guan, H.4    Delauter, L.5    Kleinerman, E.S.6
  • 51
    • 0036636786 scopus 로고    scopus 로고
    • Fas expression inversely correlates with metastatic potential in osteosarcoma cells
    • Worth LL, Lafleur EA, Jia SF, Kleinerman ES: Fas expression inversely correlates with metastatic potential in osteosarcoma cells. Oncol Rep. 2002;9:823-827.
    • (2002) Oncol Rep , vol.9 , pp. 823-827
    • Worth, L.L.1    Lafleur, E.A.2    Jia, S.F.3    Kleinerman, E.S.4
  • 52
    • 0041941097 scopus 로고    scopus 로고
    • Mechanisms for T-cell selective cytotoxicity of arabinosylguanine
    • Rodriguez CO, Jr., Stellrecht CM, Gandhi V: Mechanisms for T-cell selective cytotoxicity of arabinosylguanine. Blood. 2003;102:1842-1848.
    • (2003) Blood , vol.102 , pp. 1842-1848
    • Rodriguez Jr., C.O.1    Stellrecht, C.M.2    Gandhi, V.3
  • 53
    • 0032742205 scopus 로고    scopus 로고
    • Cytotoxic drugs and the CD95 pathway
    • Friesen C, Fulda S, Debatin KM: Cytotoxic drugs and the CD95 pathway. Leukemia. 1999;13:1854-11848
    • (1999) Leukemia , vol.13 , pp. 1854-11848
    • Friesen, C.1    Fulda, S.2    Debatin, K.M.3
  • 54
    • 0033062872 scopus 로고    scopus 로고
    • Induction of CD95 ligand and apoptosis by doxorubicin is modulated by the redox state in chemosensitive- and drug-resistant tumor cells
    • Friesen C, Fulda S, Debatin KM: Induction of CD95 ligand and apoptosis by doxorubicin is modulated by the redox state in chemosensitive- and drug-resistant tumor cells. Cell Death Differ. 1999;6:471-480.
    • (1999) Cell Death Differ , vol.6 , pp. 471-480
    • Friesen, C.1    Fulda, S.2    Debatin, K.M.3
  • 55
    • 0027347270 scopus 로고
    • Liposome-encapsulated muramyl tripeptide: A new biologic response modifier for the treatment of osteosarcoma
    • Kleinerman ES, Maeda M, Jaffe N: Liposome-encapsulated muramyl tripeptide: a new biologic response modifier for the treatment of osteosarcoma. Cancer Treat Res. 1993; 62:101-107.
    • (1993) Cancer Treat Res , vol.62 , pp. 101-107
    • Kleinerman, E.S.1    Maeda, M.2    Jaffe, N.3
  • 57
    • 33846305065 scopus 로고    scopus 로고
    • Monitoring response to anticancer therapy by targeting microbubbles to tumor vasculature
    • Korpanty G, Carbon JG, Grayburn PA, Fleming JB, Brekken RA: Monitoring response to anticancer therapy by targeting microbubbles to tumor vasculature. Clin Cancer Res. 2007;13:323-330.
    • (2007) Clin Cancer Res , vol.13 , pp. 323-330
    • Korpanty, G.1    Carbon, J.G.2    Grayburn, P.A.3    Fleming, J.B.4    Brekken, R.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.