Immunization by a bacterial aerosol

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 12, 2008, Pages 4656-4660

  Garcia Contreras, Lucila ^a   Wong, Yun Ling ^b   Muttil, Pavan ^a   Padilla, Danielle ^a   Sadoff, Jerry ^c   DeRousse, Jessica ^b   Germishuizen, Willem Andreas ^d   Goonesekera, Sunali ^e   Elbert, Katharina ^b   Bloom, Barry R ^e   Miller, Rich ^f   Fourie, P Bernard ^d   Hickey, Anthony ^a   Edwards, David ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b HARVARD UNIVERSITY   (United States)

^c Aeras Global TB Vaccine Foundation   (United States)

^d SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^e HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^f Manta   (United States)

Author keywords

Bacillus Calmette Gu rin; Inhaled particles; Live attenuated vaccines; Spray drying; Tuberculosis

Indexed keywords

BCG VACCINE; NANOPARTICLE; BACTERIAL VACCINE; LEUCINE; TUBERCULIN;

AEROSOL; AIRFLOW; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNIZATION; MALE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; SPRAY DRYING; TUBERCULOSIS; VIRULENCE; ANIMAL; DELAYED HYPERSENSITIVITY; DRUG ADMINISTRATION ROUTE; DRUG EFFECT; GUINEA PIG; HUMIDITY; IMMUNOLOGY; LUNG; METHODOLOGY; MICROBIAL VIABILITY; MICROBIOLOGY; MYCOBACTERIUM SMEGMATIS; PATHOLOGY; SPLEEN; ULTRASTRUCTURE;

ANIMALIA; BACTERIA (MICROORGANISMS); CAVIA; MYCOBACTERIUM BOVIS BCG; MYCOBACTERIUM TUBERCULOSIS;

AEROSOLS; ANIMALS; BACTERIAL VACCINES; BCG VACCINE; DRUG ADMINISTRATION ROUTES; GUINEA PIGS; HUMIDITY; HYPERSENSITIVITY, DELAYED; IMMUNIZATION; LEUCINE; LUNG; MALE; MICROBIAL VIABILITY; MYCOBACTERIUM SMEGMATIS; SPLEEN; TUBERCULIN;

EID: 42449127139     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0800043105     Document Type: Article

References (18)

1. Bivas-Benita M, Ottenhoff THM, Junginger HE, Borchard G (2005) Pulmonary DNA vaccination: Concepts, possibilities and perspectives. J Control Rel 107:1-29.
2. Lu D, Hickey AJ (2007) Pulmonary vaccine delivery. Exp Rev Vaccines 6:213-226.
3. Fuchs NA (1964) Size and shape of aerosol particles, in Mechanics of Aerosols (Pergamon, Oxford, UK), pp 1-20.
4. Bell JH, Hartley PS, Cox JSG (1971) Dry powder aerosols. I. A new powder inhalation device. J Pharm Sci 60:1559-1564.
5. Hickey AJ, Fults KA, Pillai RS (1992) Use of particle morphology to influence delivery of drugs from dry powder aerosols. J Biopharm Sci 3:107-113.
6. Edwards D (1997) Large porous particles for pulmonary drug delivery. Science 276:1868-1871.
7. Davies CN (1979) Particle fluid interactions. J Aerosol Sci 10:477-513.
8. Harris RL, Timbrell V (1977) The influence of fiber shape in lung deposition: Mathematical estimates. Inhaled Particles, ed Walton WH (Pergamon, Oxford, UK), Vol 4, pp 75-89.
9. Kottrappa P (1970) in Rochester Third International Conference on Environmental Toxicity, eds Mercer TT, Morrow PE, Stober W (CC Thomas, Springfield, IL), Vol 14, pp 249-289.
10. Chan HK, Gonda I (1989) Aerodynamic properties of elongated particles of cromoglycic acid. J Aerosol Sci 20:157.
11. Gonda I, El Khalik, AFA (1985) On the calculation of aerodynamic diameter of fibers. Aerosol Sci Tech 4:233-238.
12. Crowder TM, Rosati J, Shroeder J, Hickey AJ, Martonen TB (2002) Fundamental effects of particle morphology on lung delivery: Predictions of Stokes' law and the particular relevance to dry powder inhaler formulation and development. Pharm Res 19:239-245.
13. Concessio NM, Hickey AJ (1997) Descriptors of irregular particle morphology and powder properties. Adv Drug Del Rev 26:29-40.
14. Fults KA, Miller IF, Hickey AJ (1997) Effect of particle morphology on emitted dose of fatty acid-treated disodium cromoglycate powder aerosols. Pharm Dev Tech 2:67-79.
15. Wong Y-L, et al. (2007) Drying a tuberculosis vaccine without freezing. Proc Natl Acad Sci USA 104:2591-2595.
16. Flynn J (2004) Immunology of tuberculosis and implication in vaccine development. Tuberculosis 84:93-101.
17. Rosenthal SR, McEnery JT, Raisys N (1968) Aerogenic BCG vaccination against tuberculosis in animal and human subjects. J Asthma Res 5:309-323.
18. Lagranderie M, et al. (1993) BCG-induced protection in guinea pigs vaccinated and challenged via the respiratory route. Tubercle Lung Dis 74:38-46.