Non-steroidal anti-inflammatory drug for pulmonary administration: Design and investigation of ketoprofen lysinate fine dry powders

International Journal of Pharmaceutics

Volumn 448, Issue 1, 2013, Pages 198-204

  Stigliani, Mariateresa ^a   Aquino, Rita P ^a   Del Gaudio, Pasquale ^a   Mencherini, Teresa ^a   Sansone, Francesca ^a   Russo, Paola ^a  

^a UNIVERSITY OF SALERNO   (Italy)

Author keywords

CF artificial mucus; Cystic fibrosis; Dry powder inhaler; Ketoprofen lysine salt; l Leucine; NSAIDs

Indexed keywords

KETOPROFEN LYSINE; LEUCINE;

AEROSOL; ARTICLE; CELL PROLIFERATION; CYSTIC FIBROSIS; CYTOTOXICITY; DRUG SOLUBILITY; DRY POWDER; EPITHELIUM CELL; HUMAN; LUNG FLUID; MORPHOLOGY; PARTICLE SIZE; PRIORITY JOURNAL; SPRAY DRYING;

ADMINISTRATION, INHALATION; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CALORIMETRY, DIFFERENTIAL SCANNING; CELL LINE; CELL PROLIFERATION; CYSTIC FIBROSIS; DRUG COMPOUNDING; DRUG DESIGN; DRY POWDER INHALERS; HUMANS; KETOPROFEN; LEUCINE; LYSINE; MICROSCOPY, ELECTRON, SCANNING; MUCUS; PARTICLE SIZE; POWDERS;

EID: 84875965687     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.03.030     Document Type: Article

References (27)

1. R.P. Aquino, L. Prota, G. Auriemma, A. Santoro, T. Mencherini, G. Colombo, and P. Russo Dry powder inhalers of gentamicin and leucine: formulation parameters, aerosol performance and in vitro toxicity on CuFi1 cells Int. J. Pharm. 426 2012 100 107
2. D.S. Armstrong, S.M. Hook, K.M. Jamsen, G.M. Nixon, R. Carzino, J.B. Carlin, C.F. Robertson, and K. Grimwood Lower airway inflammation in infants with cystic fibrosis detected by newborn screening Pediatr. Pulmonol. 40 2005 500 510 (Pubitemid 41720706)
3. I.M. Balfour-Lynn, N.J. Klein, and R. Dinwiddie Randomised controlled trial of inhaled corticosteroids (fluticasone propionate) in cystic fibrosis Arch. Dis. Child. 77 1997 124 130 (Pubitemid 27398214)
4. K. Balough, M. McCubbin, M. Weinberger, W. Smits, R. Ahrens, and R. Fick The relationship between infection and inflammation in the early stages of lung disease from cystic fibrosis Pediatr. Pulmonol. 20 1995 63 70
5. J.F. Chmiel, and P.B. Davis State of the art: why do the lungs of patients with cystic fibrosis become infected and why cannot they clear the infection? Respir. Res. 4 8 2003
6. A.H.L. Chow, H.H.Y. Tong, P. Chattopadhyay, and B.Y. Shekunov Particle engineering for pulmonary drug delivery Pharm. Res. 24 2007 411 437 (Pubitemid 46295160)
7. G. Colombo, C. Parlati, and P. Russo Pharmaceutical development studies for inhalation products Inhalation Drug Delivery - Techniques and Products 2013 Wiley Blackwell Chichester, UK pp. 145-168
8. P.B. Davis, M. Drumm, and M.W. Konstan Cystic fibrosis Am. J. Respir. Crit. Care Med. 154 1996 1229 1256 (Pubitemid 26391164)
9. E. DiMango, H.J. Zar, R. Bryan, and A. Prince Diverse Pseudomonas aeruginosa gene products stimulate respiratory epithelial cells to produce interleukin-8 J. Clin. Invest. 96 1995 2204 2210
10. R.F. Donnelly, P.A. McCarron, C.M. Cassidy, J.S. Elborn, and M.M. Tunney Delivery of photosensitisers and light through mucus: investigations into the potential use of photodynamic therapy for treatment of Pseudomonas aeruginosa cystic fibrosis pulmonary infection J. Control. Release 117 2007 217 226 (Pubitemid 46161880)
11. M.W. Konstan, J.E. Krenicky, M.R. Finney, H.L. Kirchner, K.A. Hilliard, J.B. Hilliard, P.B. Davis, and C.L. Hoppel Effect of ibuprofen on neutrophil migration in vivo in cystic fibrosis and healthy subjects J. Pharmacol. Exp. Ther. 306 2003 1086 1091 (Pubitemid 37025317)
12. M.W. Konstan, M.D. Schluchter, W. Xue, and P.B. Davis Clinical use of Ibuprofen is associated with slower FEV1 decline in children with cystic fibrosis Am. J. Respir. Crit. Care Med. 176 2007 1084 1089 (Pubitemid 350223754)
13. M.S. Muhlebach, W. Reed, and T.L. Noah Quantitative cytokine gene expression in CF airway Pediatr. Pulmonol. 37 2004 393 399 (Pubitemid 38620060)
14. G. Pilcer, and K. Amighi Formulation strategy and use of excipients in pulmonary drug delivery Int. J. Pharm. 392 2010 1 19
15. L. Prota, A. Santoro, M. Bifulco, R.P. Aquino, T. Mencherini, and P. Russo Leucine enhances aerosol performance of naringin dry powder and its activity on cystic fibrosis airway epithelial cells Int. J. Pharm. 412 2011 8 19
16. M. Rosenfeld, R.L. Gibson, S. McNamara, J. Emerson, J.L. Burns, R. Castile, P. Hiatt, K. McCoy, C.B. Wilson, A. Inglis, A. Smith, T.R. Martin, and B.W. Ramsey Early pulmonary infection. inflammation, and clinical outcomes in infants with cystic fibrosis Pediatr. Pulmonol. 32 2001 356 366 (Pubitemid 33015652)
17. P. Russo, A. Santoro, L. Prota, M. Stigliani, and R.P. Aquino Development and investigation of dry powder inhalers for cystic fibrosis A.D. Sezer, Recent Advances in Novel Drug Carrier Systems 2012 Rijeka Croatia
18. P. Russo, M. Stigliani, L. Prota, G. Auriemma, C. Crescenzi, A. Porta, and R.P. Aquino Gentamicin and leucine inhalable powder: what about antipseudomonal activity and permeation through cystic fibrosis mucus? Int. J. Pharm. 440 2013 250 255
19. S.D. Sagel, J.F. Chmiel, and M.W. Konstan Sputum biomarkers of inflammation in cystic fibrosis lung disease Proc. Am. Thorac. Soc. 4 2007 406 417 (Pubitemid 47330878)
20. F. Sansone, R.P. Aquino, P. Del Gaudio, P. Colombo, and P. Russo Physical characteristics and aerosol performance of naringin dry powders for pulmonary delivery prepared by spray-drying Eur. J. Pharm. Biopharm. 72 2009 206 213
21. P.O. Schiotz, M. Jorgensen, E.W. Flensborg, O. Faero, S. Husby, N. Hoiby, S.V. Jacobsen, H. Nielsen, and S.E. Svehag Chronic Pseudomonas aeruginosa lung infection in cystic fibrosis, A longitudinal study of immune complex activity and inflammatory response in sputum sol-phase of cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infections: influence of local steroid treatment Acta Paediatr. Scand. 72 1983 283 287 (Pubitemid 13147553)
22. M.L. Stewart, and J.L. Slavin Particle size and fraction of wheat bran influence short-chain fatty acid production in vitro Br. J. Nutr. 102 2009 1404 1407
23. M.J. Telko, and A.J. Hickey Dry powder inhaler formulation Respir. Care 50 2005 1209 1227 (Pubitemid 46187575)
24. A. Venkatakrishnan, A.A. Stecenko, G. King, T.R. Blackwell, K.L. Brigham, J.W. Christman, and T.S. Blackwell Exaggerated activation of nuclear factor-kappaB and altered IkappaB-beta processing in cystic fibrosis bronchial epithelial cells Am. J. Respir. Cell Mol. Biol. 23 2000 396 403
25. - channel function Am. J. Physiol. Lung Cell Mol. Physiol. 281 2001 L71 L78
26. Y. Yang, M.D. Tsifansky, S. Shin, Q. Lin, and Y. Yeo Mannitol-guided delivery of Ciprofloxacin in artificial cystic fibrosis mucus model Biotechnol. Bioeng. 108 2011 1441 1449
27. E.T. Zemanick, B.D. Wagner, J.K. Harris, J.S. Wagener, F.J. Accurso, and S.D. Sagel Pulmonary exacerbations in cystic fibrosis with negative bacterial cultures Pediatr. Pulmonol. 45 2010 569 577