BDNF contributes to the development of neuropathic pain by induction of spinal long-term potentiation via SHP2 associated GluN2B-containing NMDA receptors activation in rats with spinal nerve ligation

Neurobiology of Disease

Volumn 73, Issue , 2015, Pages 428-451

  Ding, Xu ^a,b   Cai, Jie ^a,b   Li, Song ^a,b   Liu, Xiao Dan ^a,b   Wan, You ^a,b   Xing, Guo Gang ^a,b,c  

^a PEKING UNIVERSITY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Brain derived neurotrophic factor; GluN2B containing NMDA receptor; Long term potentiation; Neuropathic pain; SHP2; Spinal dorsal horn

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN TYROSINE PHOSPHATASE SHP 2; NR2B NMDA RECEPTOR; NSC-87877; QUINOLINE DERIVATIVE;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ELECTROSTIMULATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HIGH FREQUENCY ELECTRICAL STIMULATION; LONG TERM POTENTIATION; MALE; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SCIATIC NERVE; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN; SYNAPSE; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; DISEASE MODEL; DRUG EFFECTS; HYPERALGESIA; INJURIES; METABOLISM; NEURALGIA; PHYSIOLOGY; SPINAL NERVE; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; DISEASE MODELS, ANIMAL; HYPERALGESIA; LONG-TERM POTENTIATION; MALE; NEURALGIA; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN; SPINAL NERVES;

EID: 84910020026     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2014.10.025     Document Type: Article

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