Spinal SIRPα1-SHP2 interaction regulates spinal nerve ligation-induced neuropathic pain via PSD-95-dependent NR2B activation in rats

Pain

Volumn 153, Issue 5, 2012, Pages 1042-1053

  Peng, Hsien Yu ^a,b   Chen, Gin Den ^c   Lai, Cheng Yuang ^d,e   Hsieh, Ming Chun ^d,e   Lin, Tzer Bin ^b,d,f  

^a MACKAY MEDICAL COLLEGE   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^f NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

NMDA; NR2B; NSC 87877; PSD 95; SHP2; SIRP 1; Spinal nerve ligation

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; NEUTRALIZING ANTIBODY; NSC 87877; PROTEIN; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE SHP 2; SIGNAL REGULATORY PROTEIN ALPHA 1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; MALE; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN; SPINAL NERVE LIGATION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; HYPERALGESIA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; NEURALGIA; PAIN MEASUREMENT; PHOSPHORYLATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, IMMUNOLOGIC; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL NERVES;

EID: 84862825174     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2012.02.006     Document Type: Article

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