-
1
-
-
77955857970
-
Clinical features and pathogenesis of Alzheimer's disease: Involvement of mitochondria and mitochondrial DNA
-
PubMed: 20687493
-
Mancuso M, Orsucci D, LoGerfo A, Calsolaro V, Siciliano G (2010) Clinical features and pathogenesis of Alzheimer's disease: Involvement of mitochondria and mitochondrial DNA. Adv Exp Med Biol 685: 34-44. PubMed: 20687493.
-
(2010)
Adv Exp Med Biol
, vol.685
, pp. 34-44
-
-
Mancuso, M.1
Orsucci, D.2
LoGerfo, A.3
Calsolaro, V.4
Siciliano, G.5
-
2
-
-
17344385275
-
Clinical features of Alzheimer's disease
-
PubMed: 10653284
-
Förstl H, Kurz A (1999) Clinical features of Alzheimer's disease. Eur Arch Psychiatry Clin Neurosci 249: 288-290. PubMed: 10653284.
-
(1999)
Eur Arch Psychiatry Clin Neurosci
, vol.249
, pp. 288-290
-
-
Förstl, H.1
Kurz, A.2
-
3
-
-
78149479582
-
Dementia and stroke: The present and future epidemic
-
PubMed: 21050400
-
Cumming T, Brodtmann A (2010) Dementia and stroke: The present and future epidemic. Int J Stroke 5: 453-454. doi: 10.1111/j.1747-4949.2010.00527.x. PubMed: 21050400.
-
(2010)
Int J Stroke
, vol.5
, pp. 453-454
-
-
Cumming, T.1
Brodtmann, A.2
-
4
-
-
63849213473
-
Nicotinic acetylcholine receptor signalling: Roles in Alzheimer's disease and amyloid neuroprotection
-
PubMed: 19293145
-
Buckingham SD, Jones AK, Brown LA, Sattelle DB (2009) Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. Pharmacol Rev 61: 39-61. doi: 10.1124/pr.108.000562. PubMed: 19293145.
-
(2009)
Pharmacol Rev
, vol.61
, pp. 39-61
-
-
Buckingham, S.D.1
Jones, A.K.2
Brown, L.A.3
Sattelle, D.B.4
-
5
-
-
75649135280
-
Neuropathology of Alzheimer's disease
-
PubMed: 20101720
-
Perl DE (2010) Neuropathology of Alzheimer's disease. Mt Sinai J Med 77: 32-42. doi: 10.1002/msj.20157. PubMed: 20101720.
-
(2010)
Mt Sinai J Med
, vol.77
, pp. 32-42
-
-
Perl, D.E.1
-
6
-
-
84863337843
-
Alzheimer mechanisms and therapeutic strategies
-
PubMed: 22424230
-
Huang Y, Mucke L (2012) Alzheimer mechanisms and therapeutic strategies. Cell 148: 1204-1222. doi: 10.1016/j.cell.2012.02.040. PubMed: 22424230.
-
(2012)
Cell
, vol.148
, pp. 1204-1222
-
-
Huang, Y.1
Mucke, L.2
-
7
-
-
0033613129
-
Cellular mechanisms of beta-amyloid production and secretion
-
PubMed: 10500121
-
Sinha S, Lieberburg I (1999) Cellular mechanisms of beta-amyloid production and secretion. Proc Natl Acad Sci USA 96: 11049-11053. PubMed: 10500121.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 11049-11053
-
-
Sinha, S.1
Lieberburg, I.2
-
8
-
-
75149136696
-
Alzheimer's disease and the amyloid-beta peptide
-
PubMed: 20061647
-
Murphy MP, LeVine H 3rd (2010) Alzheimer's disease and the amyloid-beta peptide. J Alzheimers Dis 19: 311-23. doi: 10.3233/JAD-2010-1221. PubMed: 20061647.
-
(2010)
J Alzheimers Dis
, vol.19
, pp. 311-323
-
-
Murphy, M.P.1
LeVine 3rd, H.2
-
9
-
-
58849097554
-
A comparative study of beta-amyloid peptides Abeta1-42 and Abeta25-35 toxicity in organotypic hippocampal slice cultures
-
PubMed: 18686032
-
Frozza RL, Horn AP, Hoppe JB, Simão F, Gerhardt D et al. (2009) A comparative study of beta-amyloid peptides Abeta1-42 and Abeta25-35 toxicity in organotypic hippocampal slice cultures. Neurochem Res 34: 295-303. doi: 10.1007/s11064-008-9776-8. PubMed: 18686032.
-
(2009)
Neurochem Res
, vol.34
, pp. 295-303
-
-
Frozza, R.L.1
Horn, A.P.2
Hoppe, J.B.3
Simão, F.4
Gerhardt, D.5
-
10
-
-
0028123071
-
Alzheimer's disease: A central role for amyloid
-
PubMed: 8083687
-
Selkoe DJ (1994) Alzheimer's disease: a central role for amyloid. J Neuropathol Exp Neurol 53: 438-447. PubMed: 8083687.
-
(1994)
J Neuropathol Exp Neurol
, vol.53
, pp. 438-447
-
-
Selkoe, D.J.1
-
11
-
-
77950994646
-
Autophagy: Cellular and molecular mechanisms
-
PubMed: 20225336
-
Glick D, Barth S, Macleod KF (2010) Autophagy: cellular and molecular mechanisms. J Pathol 221: 3-12. doi: 10.1002/path.2697. PubMed: 20225336.
-
(2010)
J Pathol
, vol.221
, pp. 3-12
-
-
Glick, D.1
Barth, S.2
Macleod, K.F.3
-
12
-
-
35448981935
-
Autophagy: From phenomenology to molecular understanding in less than a decade
-
PubMed: 17712358
-
Klionsky DJ (2007) Autophagy: from phenomenology to molecular understanding in less than a decade. Nat. Rev. Mol. Cell Biol 8: 931-937. PubMed: 17712358.
-
(2007)
Nat. Rev. Mol. Cell Biol
, vol.8
, pp. 931-937
-
-
Klionsky, D.J.1
-
13
-
-
74949090299
-
An overview of the molecular mechanism of autophagy
-
PubMed: 19802558
-
Yang Z, Klionsky DJ (2009) An overview of the molecular mechanism of autophagy. Curr Top Microbiol Immunol 335:1-32. doi: 10.1007/978-3-642-00302-8-1. PubMed: 19802558.
-
(2009)
Curr Top Microbiol Immunol
, vol.335
, pp. 1-32
-
-
Yang, Z.1
Klionsky, D.J.2
-
14
-
-
79551598347
-
AMPKand mTOR regulate autophagy through direct phosphorylation of Ulk1
-
PubMed: 21258367
-
Kim J, Kundu M, Viollet B, Guan KL (2011) AMPKand mTOR regulate autophagy through direct phosphorylation of Ulk1. Nature cell biology 13(2):132-41. doi: 10.1038/ncb2152. PubMed: 21258367.
-
(2011)
Nature Cell Biology
, vol.13
, Issue.2
, pp. 132-141
-
-
Kim, J.1
Kundu, M.2
Viollet, B.3
Guan, K.L.4
-
15
-
-
14844303381
-
Extensive involvement of autophagy in Alzheimer disease: An immuno-electron microscopy study
-
PubMed: 15751225
-
Nixon RA, Wegiel J, Kumar A, Yu WH, Peterhoff C et al. (2005) Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J Neuropathol Exp Neurol 64: 113-122. PubMed: 15751225.
-
(2005)
J Neuropathol Exp Neurol
, vol.64
, pp. 113-122
-
-
Nixon, R.A.1
Wegiel, J.2
Kumar, A.3
Yu, W.H.4
Peterhoff, C.5
-
16
-
-
38449091923
-
The autophagy-lysosomal degradation pathway: Role in neurodegenerative disease and therapy
-
PubMed: 17981582
-
Shacka JJ, Roth KA, Zhang J (2008) The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy. Front Biosci 13: 718-736. PubMed: 17981582.
-
(2008)
Front Biosci
, vol.13
, pp. 718-736
-
-
Shacka, J.J.1
Roth, K.A.2
Zhang, J.3
-
17
-
-
79451471809
-
Brain aging and Aβ1-42 neurotoxicity converge via deterioration in autophagy-lysosomal system: A conditional Drosophila model linking Alzheimer's neurodegeneration with aging
-
PubMed: 21076961
-
Ling D, Salvaterra PM (2011) Brain aging and Aβ1-42 neurotoxicity converge via deterioration in autophagy-lysosomal system: a conditional Drosophila model linking Alzheimer's neurodegeneration with aging. Acta Neuropathol 121: 183-191. doi: 10.1007/s00401-010-0772-0. PubMed: 21076961.
-
(2011)
Acta Neuropathol
, vol.121
, pp. 183-191
-
-
Ling, D.1
Salvaterra, P.M.2
-
18
-
-
0033964077
-
Neuronal nicotinic receptors in the human brain
-
PubMed: 10759066
-
Paterson D, Nordberg A (2000) Neuronal nicotinic receptors in the human brain. Prog Neurobiol 61: 75-111. PubMed: 10759066.
-
(2000)
Prog Neurobiol
, vol.61
, pp. 75-111
-
-
Paterson, D.1
Nordberg, A.2
-
19
-
-
0035251677
-
Nicotinic receptor abnormalities of Alzheimer's disease: Therapeutic implications
-
PubMed: 11230871
-
Nordberg A (2001) Nicotinic receptor abnormalities of Alzheimer's disease: therapeutic implications. Biol Psychiatry 49: 200-210. PubMed: 11230871.
-
(2001)
Biol Psychiatry
, vol.49
, pp. 200-210
-
-
Nordberg, A.1
-
20
-
-
77957747343
-
Granulocyte colony-stimulating factor attenuates chronic neuroinflammation in the brain of amyloid precursor protein transgenic mice: An Alzheimer's disease mouse model
-
PubMed: 20926003
-
Jiang H, Liu CX, Feng JB, Wang P, Zhao CP et al. (2010) Granulocyte colony-stimulating factor attenuates chronic neuroinflammation in the brain of amyloid precursor protein transgenic mice: an Alzheimer's disease mouse model. J Int Med Res 38: 1305-1312. PubMed: 20926003.
-
(2010)
J Int Med Res
, vol.38
, pp. 1305-1312
-
-
Jiang, H.1
Liu, C.X.2
Feng, J.B.3
Wang, P.4
Zhao, C.P.5
-
21
-
-
0034006944
-
beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology
-
PubMed: 10681545
-
Wang HY, Lee DH, D'Andrea MR, Peterson PA, Shank RP et al. (2000) beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology. J Biol Chem 275: 5626-5632. PubMed: 10681545.
-
(2000)
J Biol Chem
, vol.275
, pp. 5626-5632
-
-
Wang, H.Y.1
Lee, D.H.2
D'Andrea, M.R.3
Peterson, P.A.4
Shank, R.P.5
-
22
-
-
0027054591
-
Blockade of nicotinic currents in hippocampal neurons defines methyllycaconitine as a potent and specific receptor antagonist
-
PubMed: 1569927
-
Alkondon M, Pereira EF, Wonnacott S, Albuquerque EX (1992) Blockade of nicotinic currents in hippocampal neurons defines methyllycaconitine as a potent and specific receptor antagonist. Mol Pharmacol 41: 802-808. PubMed: 1569927.
-
(1992)
Mol Pharmacol
, vol.41
, pp. 802-808
-
-
Alkondon, M.1
Pereira, E.F.2
Wonnacott, S.3
Albuquerque, E.X.4
-
23
-
-
84865645594
-
The a 7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia
-
PubMed: 22884467
-
Thomsen MS, Mikkelsen JD (2012) The a 7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia. J Neuroimmunol 251: 65-72. doi: 10.1016/j.jneuroim.2012.07.006. PubMed: 22884467.
-
(2012)
J Neuroimmunol
, vol.251
, pp. 65-72
-
-
Thomsen, M.S.1
Mikkelsen, J.D.2
-
24
-
-
27144473613
-
Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations
-
PubMed: 16193063
-
Hansen SB, Sulzenbacher G, Huxford T, Marchot P, Taylor P et al. (2005) Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations. EMBO J 24: 3635-3646. PubMed: 16193063.
-
(2005)
EMBO J
, vol.24
, pp. 3635-3646
-
-
Hansen, S.B.1
Sulzenbacher, G.2
Huxford, T.3
Marchot, P.4
Taylor, P.5
-
25
-
-
67651152791
-
Liquiritigenin inhibits Abeta(25-35)-induced neurotoxicity and secretion of Abeta(1-40) in rat hippocampal neurons
-
Liu RT1, Zou LB, Lü QJ (2009) Liquiritigenin inhibits Abeta(25-35)-induced neurotoxicity and secretion of Abeta(1-40) in rat hippocampal neurons. Acta Pharmacol Sin 30(7):899-906. doi: 10.1038/aps.2009.74.
-
(2009)
Acta Pharmacol Sin
, vol.30
, Issue.7
, pp. 899-906
-
-
Liu, R.T.1
Zou, L.B.2
Lü, Q.J.3
-
26
-
-
84871413462
-
Genistein inhibits Aβ25 - 35-Induced neurotoxicity in PC12 cells via PKC signaling pathway
-
PubMed: 22949092
-
Luo S, Lan T, Liao W, Zhao M, Yang H (2012) Genistein inhibits Aβ25 - 35-induced neurotoxicity in PC12 cells via PKC signaling pathway. Neurochem Res 37: 2787-2794. doi: 10.1007/s11064-012-0872-4. PubMed: 22949092.
-
(2012)
Neurochem Res
, vol.37
, pp. 2787-2794
-
-
Luo, S.1
Lan, T.2
Liao, W.3
Zhao, M.4
Yang, H.5
-
27
-
-
68849129707
-
RAGE regulates BACE1 and Abeta generation via NFAT1 activation in Alzheimer's disease animal model
-
PubMed: 19332646
-
Cho HJ, Son SM, Jin SM, Hong HS, Shin DH et al. (2009) RAGE regulates BACE1 and Abeta generation via NFAT1 activation in Alzheimer's disease animal model. FASEB J 23: 2639-2649. doi: 10.1096/fj.08-126383. PubMed: 19332646.
-
(2009)
FASEB J
, vol.23
, pp. 2639-2649
-
-
Cho, H.J.1
Son, S.M.2
Jin, S.M.3
Hong, H.S.4
Shin, D.H.5
-
28
-
-
0029670228
-
Inhibition of age-induced beta-amyloid neurotoxicity in rat hippocampal cells
-
PubMed: 8593898
-
Puttfarcken PS, Manelli AM, Neilly J, Frail DE (1996) Inhibition of age-induced beta-amyloid neurotoxicity in rat hippocampal cells. Exp Neurol 138: 73-81. PubMed: 8593898.
-
(1996)
Exp Neurol
, vol.138
, pp. 73-81
-
-
Puttfarcken, P.S.1
Manelli, A.M.2
Neilly, J.3
Frail, D.E.4
-
29
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-termpotentiation in vivo
-
PubMed: 11932745
-
Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R et al. (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-termpotentiation in vivo. Nature 416: 535-539. PubMed: 11932745.
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Cullen, W.K.4
Anwyl, R.5
-
30
-
-
49149124343
-
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
-
PubMed: 18568035
-
Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE et al. (2008) Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med 14: 837-842. doi: 10.1038/nm1782. PubMed: 18568035.
-
(2008)
Nat Med
, vol.14
, pp. 837-842
-
-
Shankar, G.M.1
Li, S.2
Mehta, T.H.3
Garcia-Munoz, A.4
Shepardson, N.E.5
-
31
-
-
84858336588
-
Aβ-induced formation of autophagosomes is mediated by RAGE-CaMKK β-AMPK signaling
-
PubMed: 22048125
-
Son SM, Jung ES, Shin HJ, Byun J, Mook-Jung I (2012) Aβ-induced formation of autophagosomes is mediated by RAGE-CaMKK β-AMPK signaling. Neurobiology of Aging 33: 1006.e11-e23. doi: 10.1016/j.neurobiolaging.2011.09.039. PubMed: 22048125.
-
(2012)
Neurobiology of Aging
, vol.33
, pp. 1006.e11-1006.e23
-
-
Son, S.M.1
Jung, E.S.2
Shin, H.J.3
Byun, J.4
Mook-Jung, I.5
-
32
-
-
4344712684
-
Methods for monitoring autophagy
-
PubMed: 15325587
-
Mizushima N (2004) Methods for monitoring autophagy. Int J Biochem Cell Biol 36: 2491-502. PubMed: 15325587.
-
(2004)
Int J Biochem Cell Biol
, vol.36
, pp. 2491-2502
-
-
Mizushima, N.1
-
33
-
-
0012510759
-
Amyloid plaque core protein in Alzheimer disease and Down syndrome
-
PubMed: 3159021
-
Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL et al. (1985) Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci USA 82: 4245-4249. PubMed: 3159021.
-
(1985)
Proc Natl Acad Sci USA
, vol.82
, pp. 4245-4249
-
-
Masters, C.L.1
Simms, G.2
Weinman, N.A.3
Multhaup, G.4
McDonald, B.L.5
-
34
-
-
0032590054
-
Soluble pool of Ab amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
-
PubMed: 10589538
-
McLean CA, Cherny RA, Fraser FW, Fuller SJ, Smith MJ et al. (1999) Soluble pool of Ab amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann Neurol 46: 860-866. PubMed: 10589538.
-
(1999)
Ann Neurol
, vol.46
, pp. 860-866
-
-
McLean, C.A.1
Cherny, R.A.2
Fraser, F.W.3
Fuller, S.J.4
Smith, M.J.5
-
35
-
-
0032590054
-
Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
-
PubMed: 10589538
-
McLean CA, Cherny RA, Fraser FW, Fuller SJ, Smith MJ et al. (1999) Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann Neurol 46: 860-866. PubMed: 10589538.
-
(1999)
Ann Neurol
, vol.46
, pp. 860-866
-
-
McLean, C.A.1
Cherny, R.A.2
Fraser, F.W.3
Fuller, S.J.4
Smith, M.J.5
-
36
-
-
4344580888
-
Strategies for disease modification in Alzheimer's disease
-
PubMed: 15322526
-
Citron M (2004) Strategies for disease modification in Alzheimer's disease. Nat Rev Neurosci 5: 677-85. PubMed: 15322526.
-
(2004)
Nat Rev Neurosci
, vol.5
, pp. 677-685
-
-
Citron, M.1
-
37
-
-
0034719376
-
Synthesis and pharmacological characterization of [125I] iodomethyllycaconitine ([125I] Iodo-MLA). A new ligand for the α7 nicotinic acetylcholine receptor
-
PubMed: 10649969
-
Navarro HA, Zhong D, Abraham P, Xu H, Carroll FI (2000) Synthesis and pharmacological characterization of [125I] iodomethyllycaconitine ([125I] Iodo-MLA). A new ligand for the α7 nicotinic acetylcholine receptor. Journal of medicinal chemistry 43, 142-145. PubMed: 10649969.
-
(2000)
Journal of Medicinal Chemistry
, vol.43
, pp. 142-145
-
-
Navarro, H.A.1
Zhong, D.2
Abraham, P.3
Xu, H.4
Carroll, F.I.5
-
38
-
-
21344449291
-
Chronic nicotine exposure alters blood-brain barrier permeability and diminishes brain uptake of methyllycaconitine
-
2005 Jul; PubMed: 15953347
-
Lockman PR, Van der Schyf CJ, Abbruscato TJ, Allen DD (2005) Chronic nicotine exposure alters blood-brain barrier permeability and diminishes brain uptake of methyllycaconitine. J Neurochem 2005 Jul;94(1):37-44. DOI: 10.1111/j.1471-4159.2005.03162.x. PubMed: 15953347.
-
(2005)
J Neurochem
, vol.94
, Issue.1
, pp. 37-44
-
-
Lockman, P.R.1
Van Der Schyf, C.J.2
Abbruscato, T.J.3
Allen, D.D.4
-
39
-
-
75649105739
-
Cell "self-eating" (autophagy) mechanism in Alzheimer's disease
-
PubMed: 20101724
-
Funderburk SF, Marcellino BK, Yue Z (2010) Cell "self-eating" (autophagy) mechanism in Alzheimer's disease. MtSinai J Med 77: 59-68. doi: 10.1002/msj.20161. PubMed: 20101724.
-
(2010)
MtSinai J Med
, vol.77
, pp. 59-68
-
-
Funderburk, S.F.1
Marcellino, B.K.2
Yue, Z.3
-
40
-
-
84863011390
-
Butyrolactone derivative 3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)-one protects against amyloid-β peptides-induced cytotoxicity in PC12 cells
-
PubMed: 21988929
-
Yang S, Wang S, Peng N, Xie Z, Wang P et al. (2012) Butyrolactone derivative 3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)-one protects against amyloid-β peptides-induced cytotoxicity in PC12 cells. J Alzheimers Dis 28: 345-356. doi: 10.3233/JAD-2011-110863. PubMed: 21988929.
-
(2012)
J Alzheimers Dis
, vol.28
, pp. 345-356
-
-
Yang, S.1
Wang, S.2
Peng, N.3
Xie, Z.4
Wang, P.5
-
41
-
-
79960822419
-
Autophagy in aging and Alzheimer's disease: Pathologic or protective?
-
PubMed: 21422527
-
Barnett A, Brewer GJ (2011) Autophagy in aging and Alzheimer's disease: pathologic or protective? J Alzheimers Dis 25: 85-94. doi: 10.3233/JAD-2011-101989. PubMed: 21422527.
-
(2011)
J Alzheimers Dis
, vol.25
, pp. 85-94
-
-
Barnett, A.1
Brewer, G.J.2
-
42
-
-
45749114895
-
The autophagy-related protein beclin1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice
-
PubMed: 18497889
-
Pickford F, Masliah E, Britschgi M, Lucin K, Narasimhan R et al. (2008) The autophagy-related protein beclin1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest 118: 2190-2199. doi: 10.1172/JCI33585. PubMed: 18497889.
-
(2008)
J Clin Invest
, vol.118
, pp. 2190-2199
-
-
Pickford, F.1
Masliah, E.2
Britschgi, M.3
Lucin, K.4
Narasimhan, R.5
-
43
-
-
77956305343
-
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease
-
PubMed: 20376313
-
Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O et al. (2010) Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One 5: e9979. doi: 10.1371/journal.pone.0009979. PubMed: 20376313.
-
(2010)
PLoS One
, vol.5
, pp. e9979
-
-
Spilman, P.1
Podlutskaya, N.2
Hart, M.J.3
Debnath, J.4
Gorostiza, O.5
-
44
-
-
77957335213
-
Amyloid-beta1 - 42 Induces reactive oxygen species-mediated autophagic cell death in U87 and SH-SY5Y cells
-
PubMed: 20571221
-
Wang H, Ma J, Tan Y, Wang Z, Sheng C et al. (2010) Amyloid-beta1 - 42 induces reactive oxygen species-mediated autophagic cell death in U87 and SH-SY5Y cells. J Alzheimers Dis 21: 597-610. doi: 10.3233/JAD-2010-091207. PubMed: 20571221.
-
(2010)
J Alzheimers Dis
, vol.21
, pp. 597-610
-
-
Wang, H.1
Ma, J.2
Tan, Y.3
Wang, Z.4
Sheng, C.5
-
45
-
-
73949152463
-
Apoptosis and autophagy in rat cerebellar granule neuron death: Role of reactive oxygen species
-
PubMed: 19598251
-
Maycotte P, Guemez-Gamboa A, Moran J (2010) Apoptosis and autophagy in rat cerebellar granule neuron death: Role of reactive oxygen species. J Neurosci Res 88: 73-85. doi: 10.1002/jnr.22168. PubMed: 19598251.
-
(2010)
J Neurosci Res
, vol.88
, pp. 73-85
-
-
Maycotte, P.1
Guemez-Gamboa, A.2
Moran, J.3
-
46
-
-
58449101589
-
Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila
-
PubMed: 19145255
-
Ling D, Song HJ, Garza D, Neufeld TP, Salvaterra PM (2009) Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila. PLoS One 4: e4201. doi: 10.1371/journal.pone.0004201. PubMed: 19145255.
-
(2009)
PLoS One
, vol.4
, pp. e4201
-
-
Ling, D.1
Song, H.J.2
Garza, D.3
Neufeld, T.P.4
Salvaterra, P.M.5
-
47
-
-
26444587508
-
Macroautophagy - A novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease
-
PubMed: 16203860
-
Yu WH, Cuervo AM, Kumar A, Peterhoff CM, Schmidt SD et al. (2005) Macroautophagy - a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J Cell Biol 171: 87-98. PubMed: 16203860.
-
(2005)
J Cell Biol
, vol.171
, pp. 87-98
-
-
Yu, W.H.1
Cuervo, A.M.2
Kumar, A.3
Peterhoff, C.M.4
Schmidt, S.D.5
-
48
-
-
77956274584
-
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
-
PubMed: 20660724
-
Lipinski MM, Zheng B, Lu T, Yan Z, Py BF et al. (2010) Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc Natl Acad Sci USA 107: 14164-14169. doi: 10.1073/pnas.1009485107. PubMed: 20660724.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 14164-14169
-
-
Lipinski, M.M.1
Zheng, B.2
Lu, T.3
Yan, Z.4
Py, B.F.5
|