Haloperidol metabolite II prodrug: Asymmetric synthesis and biological evaluation on rat C6 glioma cells

European Journal of Medicinal Chemistry

Volumn 90, Issue , 2015, Pages 1-9

  Sozio, Piera ^a   Fiorito, Jole ^b   Di Giacomo, Viviana ^a   Di Stefano, Antonio ^a   Marinelli, Lisa ^a   Cacciatore, Ivana ^a   Cataldi, Amelia ^a   Pacella, Stephanie ^a   Turkez, Hasan ^c   Parenti, Carmela ^d   Rescifina, Antonio ^d   Marrazzo, Agostino ^d  

^a UNIVERSITY OF CHIETI   (Italy)

^b NewYork Presbyterian Hospital   (United States)

^c ERZURUM TECHNICAL UNIVERSITY   (Turkey)

^d UNIVERSITY OF CATANIA   (Italy)

Author keywords

Glioma; HDAC; Inhibitors; Medicinal chemistry; Sigma receptors

Indexed keywords

4 (4 CHLOROPHENYL) 1 [4 (4 FLUOROPHENYL) 4 HYDROXYBUTYL]PIPERIDIN 4 OL; 4 CHLORO 1 (4 FLUOROPHENYL) BUTAN 1 OL; 4 [4 (4 CHLOROPHENYL) 4 HYDROXYPIPERIDIN 1 YL] 1 (4 FLUOROPHENYL)BUTYL 4 PHENYLBUTANOATE; ANTINEOPLASTIC AGENT; DRUG METABOLITE; HALOPERIDOL; HALOPERIDOL METABOLITE II PRODRUG; UNCLASSIFIED DRUG; PRODRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASYMMETRIC SYNTHESIS; BIOLOGICAL ACTIVITY; CANCER CHEMOTHERAPY; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DRUG SCREENING; ENZYME STABILITY; GLIOBLASTOMA; GLIOMA CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROLYSIS; IN VIVO STUDY; MEMBRANE PERMEABILITY; NONHUMAN; PHYSICAL CHEMISTRY; RAT; ANIMAL; CELL SURVIVAL; CHEMICAL STRUCTURE; DOSE RESPONSE; DRUG EFFECTS; GLIOMA; METABOLISM; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL CULTURE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; GLIOMA; HALOPERIDOL; MOLECULAR STRUCTURE; PRODRUGS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84909979844     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.11.012     Document Type: Article

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