Structure-activity relationship of butyrate analogues on apoptosis, proliferation and histone deacetylase activity in HCT-116 human colorectal cancer cells

Clinical and Experimental Pharmacology and Physiology

Volumn 37, Issue 9, 2010, Pages 905-911

  Ooi, Cheng Cheng ^a   Good, Norm M ^b   Williams, Desmond B ^a   Lewanowitsch, Tanya ^a   Cosgrove, Leah J ^a   Lockett, Trevor J ^a   Head, Richard J ^a  

^a UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^b CSIRO   (Australia)

Author keywords

apoptosis; butyrate analogues; cell proliferation; colorectal cancer; histone deacetylase activity; structure activity relationship

Indexed keywords

3 (4 FLUOROBENZOYL)PROPIONATE; 3 BENZOYLPROPIONATE; 4 (4 NITROPHENYL)BUTYRATE; 4 BENZOYLBUTYRATE; BUTYRIC ACID; BUTYRIC ACID DERIVATIVE; HISTONE DEACETYLASE; HYDROXYL GROUP; LACTATE DEHYDROGENASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; COLORECTAL CANCER; CONTROLLED STUDY; DISSOCIATION; DRUG CYTOTOXICITY; DRUG EFFECT; HUMAN; HUMAN CELL; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

APOPTOSIS; BUTYRATES; CELL PROLIFERATION; COLORECTAL NEOPLASMS; CYCLOHEXANES; HCT116 CELLS; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HT29 CELLS; HUMANS; L-LACTATE DEHYDROGENASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77956028590     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2010.05403.x     Document Type: Article

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