Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning

Blood

Volumn 124, Issue 19, 2014, Pages 2937-2947

  Saez, Borja ^a,b,c   Ferraro, Francesca ^a,b,c   Yusuf, Rushdia Z ^a,b,c   Cook, Colleen M ^a,b,c   Yu, Vionnie W C ^a,b,c   Pardo Saganta, Ana ^b,c   Sykes, Stephen M ^d   Palchaudhuri, Rahul ^a,b,c   Schajnovitz, Amir ^a,b,c   Lotinun, Sutada ^e,k   Lymperi, Stefania ^a,b,c   Mendez Ferrer, Simon ^f   Del Toro, Raquel ^f   Day, Robyn ^a   Vasic, Radovan ^a   Acharya, Sanket S ^a   Baron, Roland ^e   Lin, Charles P ^c,g   Yamaguchi, Yu ^h   Wagers, Amy J ^a,c,i,j   Scadden, David T ^a,b,c   more..

^a HARVARD UNIVERSITY   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^c HARVARD STEM CELL INSTITUTE   (United States)

^d FOX CHASE CANCER CENTER   (United States)

^e HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

^f CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^g MASSACHUSETTS GENERAL HOSPITAL   (United States)

^h BURNHAM INSTITUTE   (United States)

ⁱ JOSLIN DIABETES CENTER   (United States)

^j HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^k CHULALONGKORN UNIVERSITY   (Thailand)

more..

Author keywords

[No Author keywords available]

Indexed keywords

HEPARAN SULFATE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; VASCULAR CELL ADHESION MOLECULE 1; ANTICOAGULANT AGENT; EXOSTOSIN-1; GRANULOCYTE COLONY STIMULATING FACTOR; GREEN FLUORESCENT PROTEIN; HEPARIN; N ACETYLGLUCOSAMINYLTRANSFERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CELLULAR DISTRIBUTION; CONDITIONING; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE MODEL; EXT1 GENE; GENE; GENE DELETION; GLYCOSAMINOGLYCAN METABOLISM; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEPARAN SULFATE SYNTHESIS; HOST; INTRACELLULAR SIGNALING; MOUSE; MOUSE MODEL; NONHUMAN; REDUCTION; SPLEEN; STEM CELL MOBILIZATION; STEM CELL NICHE; STROMA CELL; ANIMAL; BINDING COMPETITION; BIOSYNTHESIS; C57BL MOUSE; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; GENETICS; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; MALE; METABOLISM; PROCEDURES; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; ANTICOAGULANTS; BINDING, COMPETITIVE; DIABETES MELLITUS, EXPERIMENTAL; GRANULOCYTE COLONY-STIMULATING FACTOR; GREEN FLUORESCENT PROTEINS; HEMATOPOIETIC STEM CELL MOBILIZATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEPARIN; HEPARITIN SULFATE; MALE; MICE, INBRED C57BL; MICE, TRANSGENIC; N-ACETYLGLUCOSAMINYLTRANSFERASES; SIGNAL TRANSDUCTION; STROMAL CELLS; TRANSPLANTATION CONDITIONING; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84909608192     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-08-593426     Document Type: Article

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