Regulation of Stem Cells by Intersecting Gradients of Long-Range Niche Signals

Developmental Cell

Volumn 23, Issue 4, 2012, Pages 836-848

  Vied, Cynthia ^a,b   Reilein, Amy ^a   Field, Natania S ^a   Kalderon, Daniel ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b FLORIDA STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; JANUS KINASE; STAT PROTEIN; UVOMORULIN; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CONTACT; CELL FUNCTION; CELL STRUCTURE; CONTROLLED STUDY; DROSOPHILA; EPISTASIS; FEMALE; INSECT; NONHUMAN; OVARY FOLLICLE; PRIORITY JOURNAL; PROTEIN FUNCTION; STEM CELL;

ANIMALS; DROSOPHILA MELANOGASTER; FEMALE; OVARIAN FOLLICLE; SIGNAL TRANSDUCTION; STEM CELL NICHE; STEM CELLS;

EID: 84867672673     PISSN: 15345807     EISSN: 18781551     Source Type: Journal    
DOI: 10.1016/j.devcel.2012.09.010     Document Type: Article

References (34)

1. Arbouzova N.I., Zeidler M.P. JAK/STAT signalling in Drosophila: insights into conserved regulatory and cellular functions. Development 2006, 133:2605-2616.
2. Assa-Kunik E., Torres I.L., Schejter E.D., Johnston D.S., Shilo B.Z. Drosophila follicle cells are patterned by multiple levels of Notch signaling and antagonism between the Notch and JAK/STAT pathways. Development 2007, 134:1161-1169.
3. Bach E.A., Ekas L.A., Ayala-Camargo A., Flaherty M.S., Lee H., Perrimon N., Baeg G.H. GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo. Gene Expr. Patterns 2007, 7:323-331.
4. Chen S., Wang S., Xie T. Restricting self-renewal signals within the stem cell niche: multiple levels of control. Curr. Opin. Genet. Dev. 2011, 21:684-689.
5. de Cuevas M., Matunis E.L. The stem cell niche: lessons from the Drosophila testis. Development 2011, 138:2861-2869.
6. Decotto E., Spradling A.C. The Drosophila ovarian and testis stem cell niches: similar somatic stem cells and signals. Dev. Cell 2005, 9:501-510.
7. Dobens L.L., Raftery L.A. Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells. Dev. Dyn. 2000, 218:80-93.
8. Forbes A.J., Lin H., Ingham P.W., Spradling A.C. hedgehog is required for the proliferation and specification of ovarian somatic cells prior to egg chamber formation in Drosophila. Development 1996, 122:1125-1135.
9. Forbes A.J., Spradling A.C., Ingham P.W., Lin H. The role of segment polarity genes during early oogenesis in Drosophila. Development 1996, 122:3283-3294.
10. Hartman T.R., Zinshteyn D., Schofield H.K., Nicolas E., Okada A., O'Reilly A.M. Drosophila Boi limits Hedgehog levels to suppress follicle stem cell proliferation. J. Cell Biol. 2010, 191:943-952.
11. Jiang J., Hui C.C. Hedgehog signaling in development and cancer. Dev. Cell 2008, 15:801-812.
12. King F.J., Szakmary A., Cox D.N., Lin H. Yb modulates the divisions of both germline and somatic stem cells through piwi- and hh-mediated mechanisms in the Drosophila ovary. Mol. Cell 2001, 7:497-508.
13. Kirilly D., Spana E.P., Perrimon N., Padgett R.W., Xie T. BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary. Dev. Cell 2005, 9:651-662.
14. Kirilly D., Wang S., Xie T. Self-maintained escort cells form a germline stem cell differentiation niche. Development 2011, 138:5087-5097.
15. Lee T., Luo L. Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development. Trends Neurosci. 2001, 24:251-254.
16. López-Onieva L., Fernández-Miñán A., González-Reyes A. Jak/Stat signalling in niche support cells regulates dpp transcription to control germline stem cell maintenance in the Drosophila ovary. Development 2008, 135:533-540.
17. Losick V.P., Morris L.X., Fox D.T., Spradling A. Drosophila stem cell niches: a decade of discovery suggests a unified view of stem cell regulation. Dev. Cell 2011, 21:159-171.
18. Margolis J., Spradling A. Identification and behavior of epithelial stem cells in the Drosophila ovary. Development 1995, 121:3797-3807.
19. McGregor J.R., Xi R., Harrison D.A. JAK signaling is somatically required for follicle cell differentiation in Drosophila. Development 2002, 129:705-717.
20. Nystul T., Spradling A. An epithelial niche in the Drosophila ovary undergoes long-range stem cell replacement. Cell Stem Cell 2007, 1:277-285.
21. Nystul T., Spradling A. Regulation of epithelial stem cell replacement and follicle formation in the Drosophila ovary. Genetics 2010, 184:503-515.
22. O'Reilly A.M., Lee H.H., Simon M.A. Integrins control the positioning and proliferation of follicle stem cells in the Drosophila ovary. J. Cell Biol. 2008, 182:801-815.
23. Smelkinson M.G., Zhou Q., Kalderon D. Regulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation. Dev. Cell 2007, 13:481-495.
24. Song X., Xie T. DE-cadherin-mediated cell adhesion is essential for maintaining somatic stem cells in the Drosophila ovary. Proc. Natl. Acad. Sci. USA 2002, 99:14813-14818.
25. Song X., Xie T. Wingless signaling regulates the maintenance of ovarian somatic stem cells in Drosophila. Development 2003, 130:3259-3268.
26. Vied C., Kalderon D. Hedgehog-stimulated stem cells depend on non-canonical activity of the Notch co-activator Mastermind. Development 2009, 136:2177-2186.
27. Visvader J.E. Cells of origin in cancer. Nature 2011, 469:314-322.
28. Wang Z.A., Huang J., Kalderon D. Drosophila follicle stem cells are regulated by proliferation and niche adhesion as well as mitochondria and ROS. Nat. Commun. 2012, 3:769.
29. Wang Z.A., Kalderon D. Cyclin E-dependent protein kinase activity regulates niche retention of Drosophila ovarian follicle stem cells. Proc. Natl. Acad. Sci. USA 2009, 106:21701-21706.
30. Xi R., McGregor J.R., Harrison D.A. A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium. Dev. Cell 2003, 4:167-177.
31. Zhang Y., Kalderon D. Regulation of cell proliferation and patterning in Drosophila oogenesis by Hedgehog signaling. Development 2000, 127:2165-2176.
32. Zhang Y., Kalderon D. Hedgehog acts as a somatic stem cell factor in the Drosophila ovary. Nature 2001, 410:599-604.
33. Zhou Q., Kalderon D. Hedgehog activates fused through phosphorylation to elicit a full spectrum of pathway responses. Dev. Cell 2011, 20:802-814.
34. Zhou Q., Apionishev S., Kalderon D. The contributions of protein kinase A and smoothened phosphorylation to hedgehog signal transduction in Drosophila melanogaster. Genetics 2006, 173:2049-2062.