Diabetes impairs hematopoietic stem cell mobilization by altering niche function

Science Translational Medicine

Volumn 3, Issue 104, 2011, Pages

  Ferraro, Francesca ^a,b,c   Lymperi, Stefania ^a,b,c   Méndez Ferrer, Simón ^d   Saez, Borja ^a,b,c   Spencer, Joel A ^e,f   Yeap, Beow Y ^e   Masselli, Elena ^g   Graiani, Gallia ^g   Prezioso, Lucia ^g   Rizzini, Elisa Lodi ^g   Mangoni, Marcellina ^g   Rizzoli, Vittorio ^g   Sykes, Stephen M ^a,b,c   Lin, Charles P ^e   Frenette, Paul S ^h   Quaini, Federico ^g   Scadden, David T ^a,b,c  

^a MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^b HARVARD STEM CELL INSTITUTE   (United States)

^c Harvard University   (United States)

^d CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f Tufts University   (United States)

^g UNIVERSITY OF PARMA   (Italy)

^h ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; CXCL12 PROTEIN, MOUSE; GRANULOCYTE COLONY STIMULATING FACTOR; INTERMEDIATE FILAMENT PROTEIN; NERVE PROTEIN; NESTIN; PLERIXAFOR; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; STROMAL CELL DERIVED FACTOR 1;

ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA ADRENERGIC STIMULATION; BIOSYNTHESIS; BONE MARROW; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CD34 SELECTION; CELL ADHESION; CELL COUNT; CELL FUNCTION; CELL MOTION; CELL SEPARATION; CELL STRUCTURE; CELLULAR DISTRIBUTION; CHEMOTAXIS; CONTROLLED STUDY; CYTOLOGY; DIABETES MELLITUS; DISEASE ACTIVITY; DISEASE ASSOCIATION; DOWN REGULATION; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; MALE; METABOLISM; METHODOLOGY; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; RECEPTOR BLOCKING; RETROSPECTIVE STUDY; STEM CELL MOBILIZATION; STEM CELL NICHE; STEM CELL TRANSPLANTATION; STREPTOZOCIN DIABETES; SYMPATHETIC NERVE CELL; TREATMENT RESPONSE;

ANIMALS; ANTIGENS, CD34; BIOSYNTHESIS; BONE MARROW; BONE MARROW CELLS; CELL MOVEMENT; CELL SEPARATION; CHEMOKINE CXCL12; CYTOLOGY; FLOW CYTOMETRY; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELL MOBILIZATION; HEMATOPOIETIC STEM CELLS; HUMANS; INTERMEDIATE FILAMENT PROTEINS; MALE; METABOLISM; METHODS; MICE; NERVE TISSUE PROTEINS; STEM CELL TRANSPLANTATION;

EID: 80054035544     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3002191     Document Type: Article

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52. + cells and osteoblasts, analyzed the data, and edited the manuscript. B.S. performed the experiments and edited the manuscript. J.A.S. helped with in vivo imaging experiments. B.Y.Y. performed the statistical analysis on patient data. E.M., G.G., L.P., E.L.R., M.M., and V.R. performed the staining on human biopsies and analyzed the human data. S.M.S. performed the experiments and edited the manuscript. C.P.L. and P.S.F. contributed reagents and provided advice on the manuscript. F.Q. and D.T.S. supervised the experiments and the overall study, interpreted the data, and wrote the manuscript. Competing interests: D.T.S. is a consultant to Fate Therapeutics, Genzyme, Hospira, and Bone Therapeutics and a shareholder in Fate Therapeutics. P.S.F. is a paid consultant for Glycomimetics.