Potent inhibitors of CDK5 derived from roscovitine: Synthesis, biological evaluation and molecular modelling

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 1, 2013, Pages 125-131

  Demange, Luc ^a   Abdellah, Fatma Nait ^a   Lozach, Olivier ^b   Ferandin, Yoan ^b   Gresh, Nohad ^a   Meijer, Laurent ^b,c   Galons, Hervé ^c,d  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b CNRS   (France)

^c Centre de Perharidy   (France)

^d Laboratoire de Pharmacochimie   (France)

Author keywords

Buchwald Hartwig amination; CDK5; Kinase; Roscovitine

Indexed keywords

2,6,9 TRISUBSTITUTED PURINE DERIVATIVE; ADENOSINE TRIPHOSPHATE; CENTRAL NERVOUS SYSTEM AGENTS; CYCLIN B; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 5; CYCLIN DEPENDENT KINASE INHIBITOR; DRF 53; LYSINE; PROTEIN P25; PROTEIN SERINE THREONINE KINASE INHIBITOR; PURVALANOL; ROSCOVITINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; BINDING SITE; CATALYSIS; CELL DEATH; CLINICAL TRIAL (TOPIC); CONTROLLED STUDY; DOWN SYNDROME; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; MOLECULAR DOCKING;

BINDING SITES; CATALYTIC DOMAIN; CELL LINE, TUMOR; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE 5; HUMANS; HYDROGEN BONDING; MOLECULAR DOCKING SIMULATION; PROTEIN KINASE INHIBITORS; PURINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84871004657     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.10.141     Document Type: Article

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