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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 168-171

Discovery of potent small molecule inhibitors of DYRK1A by structure-based virtual screening and bioassay

(7) Wang, Di a Wang, Fei b Tan, Yexiong a Dong, Liwei a Chen, Lei a Zhu, Weiliang b Wang, Hongyang a

a SECOND MILITARY MEDICAL UNIVERSITY (China)

b SHANGHAI INSTITUTE OF MATERIA MEDICA (China)

Author keywords

Bioassay; Down syndrome; DYRK1A; Virtual screening

Indexed keywords

DUAL SPECIFICITY TYROSINE PHOSPHORYLATION REGULATED KINASE 1A INHIBITOR; HARMINE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; PURVALANOL; ROSCOVITINE; TG 003; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOASSAY; CONTROLLED STUDY; DOWN SYNDROME; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; FEMALE; FETUS; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; NONHUMAN; PROTEIN PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; BIOCHEMISTRY; BIOLOGICAL ASSAY; CHEMISTRY, PHARMACEUTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN SYNDROME; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MICE, TRANSGENIC; MODELS, CHEMICAL; NEURODEGENERATIVE DISEASES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES;

EID: 84655169783 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.11.043 Document Type: Article

Times cited : (24)

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