Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk)

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 23, 2009, Pages 6700-6705

  Mott, Bryan T ^a   Tanega, Cordelle ^a,b   Shen, Min ^a   Maloney, David J ^a   Shinn, Paul ^a   Leister, William ^a   Marugan, Juan J ^a   Inglese, James ^a   Austin, Christopher P ^a   Misteli, Tom ^b   Auld, Douglas S ^a   Thomas, Craig J ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Clk; Dyrk1A; Kinase inhibition; Pre mRNA splicing

Indexed keywords

6 ARYLQUINAZOLIN 4 AMINE DERIVATIVE; ADENOSINE TRIPHOSPHATE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG INHIBITION; DRUG POTENCY; DRUG SCREENING; ENZYME BINDING; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION;

AMINES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 71749110422     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.09.121     Document Type: Article

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