Theranostic unimolecular micelles based on brush-shaped amphiphilic block copolymers for tumor-targeted drug delivery and positron emission tomography imaging

ACS Applied Materials and Interfaces

Volumn 6, Issue 24, 2014, Pages 21769-21779

  Guo, Jintang ^a,b,c   Hong, Hao ^c   Chen, Guojun ^b,c   Shi, Sixiang ^b   Nayak, Tapas R ^c   Theuer, Charles P ^d   Barnhart, Todd E ^c   Cai, Weibo ^b,c   Gong, Shaoqin ^b,c  

^a TIANJIN UNIVERSITY   (China)

^b Wisconsin Electric Machines and Power Electronics Consortium   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d NONE   (United States)

Author keywords

64Cu; angiogenesis; brush polymer; brush shaped amphiphilic block copolymer; cancer; CD105; nanocarriers; positron emission tomography (PET); theranostics; unimolecular micelles

Indexed keywords

BLOCK COPOLYMERS; CONTROLLED DRUG DELIVERY; DENDRIMERS; DISEASES; ELECTRONS; ENDOTHELIAL CELLS; MAMMALS; MEDICAL IMAGING; MICELLES; MOLECULAR BIOLOGY; MONOCLONAL ANTIBODIES; PHEMA; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; POLYETHYLENE TEREPHTHALATES; POSITRON EMISSION TOMOGRAPHY; POSITRONS; THERANOSTICS; TUMORS;

AMPHIPHILIC BLOCK COPOLYMERS; ANGIOGENESIS; BRUSH POLYMERS; CANCER; CD105; NANO-CARRIERS; POSITRON EMISSION TOMOGRAPHY (PET); UNIMOLECULAR MICELLES; ^64CU;

TARGETED DRUG DELIVERY;

ANTINEOPLASTIC ANTIBIOTIC; DOXORUBICIN; DRUG CARRIER; LACTIC ACID DERIVATIVE; MACROGOL DERIVATIVE; MICELLE; POLY(LACTIC ACID-ETHYLENE GLYCOL); POLYMACON; POLYMER;

ANIMAL; BREAST NEOPLASMS; CHEMISTRY; DISEASE MODEL; FEMALE; HUMAN; MCF 7 CELL LINE; MICELLE; NEOPLASMS; POSITRON EMISSION TOMOGRAPHY; PREGNANCY; PROTON NUCLEAR MAGNETIC RESONANCE; TRANSMISSION ELECTRON MICROSCOPY; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BREAST NEOPLASMS; DISEASE MODELS, ANIMAL; DOXORUBICIN; DRUG CARRIERS; FEMALE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LACTATES; MCF-7 CELLS; MICELLES; MICROSCOPY, ELECTRON, TRANSMISSION; NEOPLASMS; POLYETHYLENE GLYCOLS; POLYHYDROXYETHYL METHACRYLATE; POLYMERS; POSITRON-EMISSION TOMOGRAPHY; PREGNANCY; PROTON MAGNETIC RESONANCE SPECTROSCOPY;

EID: 84908654048     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/am5002585     Document Type: Review

References (56)

1. Hainfeld, J. F.; Smilowitz, H. M.; OConnor, M. J.; Avraham, F. Dilmanian; Slatkin, D. N. Gold Nanoparticle Imaging and Radiotherapy of Brain Tumors in Mice Nanomedicine 2013, 8, 1601
2. Wang, L. S.; Chuang, M. C.; Ho, J. A. Nanotheranostics-a Review of Recent Publications Int. J. Nanomed. 2012, 7, 4679
3. Feng, X. L.; Lv, F. T.; Liu, L. B.; Tang, H. W.; Xing, C. F.; Yang, Q.; Wang, S. Conjugated Polymer Nanoparticles for Drug Delivery and Imaging ACS Appl. Mater. Interfaces 2010, 2, 2429-2435
4. Deng, D. W.; Qu, L. Z.; Zhang, J.; Ma, Y. X.; Gu, Y. Q. Quaternary Zn-Ag-In-Se Quantum Dots for Biomedical Optical Imaging of RGD-Modified Micelles ACS Appl. Mater. Interfaces 2013, 5, 10858-10865
5. Chen, X. S. One Year after a Successful Start of Theranostics Theranostics 2012, 2, 1
6. Yang, F.; Wang, Q.; Gu, Z. X.; Fang, K.; Marriott, G.; Gu, N. Silver Nanoparticle-Embedded Microbubble as a Dual-Mode Ultrasound and Optical Imaging Probe ACS Appl. Mater. Interfaces 2013, 5, 9217-9223
7. Xiao, Y.; Hong, H.; Javadi, A.; Engle, J. W.; Xu, W.; Yang, Y.; Zhang, Y.; Barnhart, T. E.; Cai, W.; Gong, S. Multifunctional Unimolecular Micelles for Cancer-Targeted Drug Delivery and Positron Emission Tomography Imaging Biomaterials 2012, 33, 3071
8. 64Cu-Labeled Superparamagnetic Iron Oxide Nanoparticles for Targeted Anticancer Drug Delivery and PET/MR Imaging Biomaterials 2011, 32, 4151
9. Gong, J.; Chen, M.; Zheng, Y.; Wang, S.; Wang, Y. Polymeric Micelles Drug Delivery System in Oncology J. Controlled Release 2012, 159, 312
10. Fu, Y. Z.; Su, Y. S.; Manthiram, A. Sulfur-Carbon Nanocomposite Cathodes Improved by an Amphiphilic Block Copolymer for High-Rate Lithium-Sulfur Batteries ACS Appl. Mater. Interfaces 2012, 4, 6046-6052
11. Kim, S.; Shi, Y.; Kim, J. Y.; Park, K.; Cheng, J. X. Overcoming the Barriers in Micellar Drug Delivery: Loading Efficiency, in Vivo Stability, and Micelle-Cell Interaction Expert Opin. Drug Deliv. 2010, 7, 49
12. Xu, W.; Burke, J. F.; Pilla, S.; Chen, H.; Jaskula-Sztul, R.; Gong, S. Octreotide-Functionalized and Resveratrol-Loaded Unimolecular Micelles for Targeted Neuroendocrine Cancer Therapy Nanoscale 2013, 5, 9924
13. Luo, S.; Ling, C.; Hu, X.; Liu, X.; Chen, S.; Han, M.; Xia, J. Thermoresponsive Unimolecular Micelles with a Hydrophobic Dendritic Core and a Double Hydrophilic Block Copolymer Shell J. Colloid Interface Sci. 2011, 353, 76
14. Kreutzer, G.; Ternat, C.; Nguyen, T. Q.; Plummer, C. J. G.; Månson, J.-A. E.; Castelletto, V.; Hamley, I. W.; Sun, F.; Sheiko, S. S.; Herrmann, A.; Ouali, L.; Sommer, H.; Fieber, W.; Velazco, M. I.; Klok, H.-A. Water-Soluble, Unimolecular Containers Based on Amphiphilic Multiarm Star Block Copolymers Macromolecules 2006, 39, 4507
15. Geng, Y.; Dalhaimer, P.; Cai, S.; Tsai, R.; Tewari, M.; Minko, T.; Discher, D. E. Shape Effects of Filaments Versus Spherical Particles in Flow and Drug Delivery Nat. Nanotechnol. 2007, 2, 249
16. Cai, S.; Vijayan, K.; Cheng, D.; Lima, E. M.; Discher, D. E. Micelles of Different Morphologies-Advantages of Worm-Like Filomicelles of PEO-PCL in Paclitaxel Delivery Pharm. Res. 2007, 24, 2099
17. Prabaharan, M.; Grailer, J. J.; Pilla, S.; Steeber, D. A.; Gong, S. Folate-Conjugated Amphiphilic Hyperbranched Block Copolymers based on Boltorn® H40, Poly(l -lactide) and Poly(ethylene glycol) for Tumor-Targeted drug Delivery Biomaterials 2009, 30, 3009
18. Aryal, S.; Prabaharan, M.; Pilla, S.; Gong, S. Biodegradable and Biocompatible Multi-Arm Star Amphiphilic Block Copolymer as a Carrier for Hydrophobic Drug Delivery Int. J Biol. Macromol. 2009, 44, 346
19. Zhi-Mei, M.; Si-Xue, C.; Xian-Zheng, Z.; Qing-Rong, W.; Zhuo, R.-X. Degradation and Drug Release Property of Star Poly(e-caprolactone)s with Dendritic Cores J.Biomed. Mater. Res. B: Appl. Biomater. 2006, 81B, 40
20. Prabaharan, M.; Grailer, J. J.; Pilla, S.; Steeber, D. A.; Gong, S. Amphiphilic Multi-Arm Block Copolymer based on Hyperbranched Polyester, Poly(l -lactide) and Poly(ethylene glycol) as a Drug Delivery Carrier Macromol. Biosci. 2009, 9, 515
21. Zhu, S.; Hong, M.; Zhang, L.; Tang, G.; Jiang, Y.; Pei, Y. PEGylated PAMAM Dendrimer-Doxorubicin Conjugates: in Vitro Evaluation and in Vivo Tumor Accumulation Pharm. Res. 2010, 27, 161
22. Si, C.; Xian-Zheng, Z.; Si-Xue, C.; Ren-Xi, Z.; Gu, Z.-W. Functionalized Amphiphilic Hyperbranched Polymers for Targeted Drug Delivery Biomacromolecules 2008, 9, 2578
23. Zhao, P.; Liu, L.; Feng, X.; Wang, C.; Shuai, X.; Chen, Y. Molecular Nanoworm with PCL Core and PEO Shell as a Non-Spherical Carrier for Drug Delivery Macromol. Rapid Commun. 2012, 33, 1351
24. Yan, Geng; Discher, D. E. Hydrolytic Degradation of Poly(ethylene oxide)-block-polycaprolactone Worm Micelles J. Am. Chem. Soc. 2005, 127, 12780
25. Dallas, N. A.; Samuel, S.; Xia, L.; Fan, F.; Gray, M. J.; Lim, S. J.; Ellis, L. M. Endoglin (CD105): A Marker of Tumor Vasculature and Potential Target for Therapy Clin. Cancer Res. 2008, 14, 1931
26. Seon, B. K.; Haba, A.; Matsuno, F.; Takahashi, N.; Tsujie, M.; She, X.; Harada, N.; Uneda, S.; Tsujie, T.; Toi, H.; Tsai, H.; Haruta, Y. Endoglin-Targeted Cancer Therapy Curr. Drug Delivery 2011, 8, 135
27. 66Ga-Labeled Monoclonal Antibody Mol. Pharm. 2012, 9, 1441
28. Hong, H.; Yang, K.; Zhang, Y.; Engle, J. W.; Feng, L.; Yang, Y.; Nayak, T. R.; Goel, S.; Bean, J.; Theuer, C. P.; Barnhart, T. E.; Liu, Z.; Cai, W. In Vivo Targeting and Imaging of Tumor Vasculature with Radiolabeled, Antibody-Conjugated Nanographene ACS Nano 2012, 6, 2361
29. 66Ga-Labeled Nano-Graphene Biomaterials 2012, 33, 4147
30. 64Cu-Labeled Monoclonal Antibody: NOTA is Superior to DOTA PLoS One 2011, 6, e28005
31. Guo, J.; Hong, H.; Chen, G.; Shi, S.; Zheng, Q.; Zhang, Y.; Theuer, C. P.; Barnhart, T. E.; Cai, W.; Gong, S. Image-Guided and Tumor-Targeted Drug Delivery with Radiolabeled Unimolecular Micelles Biomaterials 2013, 34, 8323
32. Hong, H.; Zhang, Y.; Severin, G. W.; Yang, Y.; Engle, J. W.; Niu, G.; Nickles, R. J.; Chen, X.; Leigh, B. R.; Barnhart, T. E.; Cai, W. Multimodality Imaging of Breast Cancer Experimental Lung Metastasis with Bioluminescence and a Monoclonal Antibody Dual-Labeled with (89)Zr and IRDye 800CW Mol. Pharm. 2012, 9, 2339
33. Rosen, L. S.; Hurwitz, H. I.; Wong, M. K.; Goldman, J.; Mendelson, D. S.; Figg, W. D.; Spencer, S.; Adams, B. J.; Alvarez, D.; Seon, B. K.; Theuer, C. P.; Leigh, B. R.; Gordon, M. S. A Phase I First-in-Human Study of TRC105 (Anti-Endoglin Antibody) in Patients with Advanced Cancer Clin. Cancer Res. 2012, 18, 4820
34. Hong, H.; Yang, Y.; Zhang, Y.; Engle, J. W.; Barnhart, T. E.; Nickles, R. J.; Leigh, B. R.; Cai, W. Positron Emission Tomography Imaging of CD105 Expression during Tumor Angiogenesis Eur. J. Nucl. Med. Mol. Imaging 2011, 38, 1335
35. 89Zr-Df-TRC105 Eur. J. Nucl. Med. Mol. Imaging 2012, 39, 138
36. Shi, S.; Yang, K.; Hong, H.; Valdovinos, H. F.; Nayak, T. R.; Zhang, Y.; Theuer, C. P.; Barnhart, T. E.; Liu, Z.; Cai, W. Tumor Vasculature Targeting and Imaging in Living Mice with Reduced Graphene Oxide Biomaterials 2013, 34, 3002
37. Zhang, Y.; Hong, H.; Engle, J. W.; Yang, Y.; Theuer, C. P.; Barnhart, T. E.; Cai, W. Positron Emission Tomography and Optical Imaging of Tumor CD105 Expression with a Dual-Labeled Monoclonal Antibody Mol. Pharm. 2012, 9, 645
38. Zhang, Y.; Hong, H.; Severin, G. W.; Engle, J. W.; Yang, Y.; Goel, S.; Nathanson, A. J.; Liu, G.; Nickles, R. J.; Leigh, B. R.; Barnhart, T. E.; Cai, W. ImmunoPET and Near-Infrared Fluorescence Imaging of CD105 Expression using a Monoclonal Antibody Dual-Labeled with (89)Zr and IRDye 800CW Am. J. Transl. Res. 2012, 4, 333
39. Zhang, Y.; Hong, H.; Engle, J. W.; Yang, Y.; Barnhart, T. E.; Cai, W. Positron Emission Tomography and Near-Infrared Fluorescence Imaging of Vascular Endothelial Growth Factor with Dual-Labeled Bevacizumab Eur. J. Nucl. Med. Mol. Imaging 2012, 2, 1
40. Hong, H.; Zhang, Y.; Severin, G. W.; Yang, Y.; Engle, J. W.; Niu, G.; Nickles, R. J.; Chen, X.; Leigh, B. R.; Barnhart, T. E.; Cai, W. Multimodality Imaging of Breast Cancer Experimental Lung Metastasis with Bioluminescence and a Monoclonal Antibody Dual-Labeled with (89)Zr and IRDye 800CW Mol. Pharm. 2012, 9, 2339
41. Wang, Y.; Grayson, S. M. Approaches for the Preparation of Non-Linear Amphiphilic Polymers and Their Applications to Drug Delivery Adv. Drug Delivery Rev. 2012, 64, 852
42. Li, J.; Li, J.; Xu, S.; Zhang, D.; Liu, D. Hydrophobic Oligopeptide-based Star-Block Copolymers as Unimolecular Nanocarriers for Poorly Water-Soluble Drugs Colloids Surf., B 2013, 110, 183
43. Nogueira, N.; Conde, O.; Minones, M.; Trillo, J. M.; Minones, J., Jr. Characterization of Poly(2-hydroxyethyl methacrylate) (PHEMA) Contact Lens using the Langmuir Monolayer Technique J. Colloid Interface Sci. 2012, 385, 202
44. Li, C.; Wang, B.; Liu, Y.; Cao, J.; Feng, T.; Chen, Y.; Luo, X. Synthesis and Evaluation of Star-shaped poly(-caprolactone)-poly(2-hydroxyethyl methacrylate) as Potential Anticancer Drug Delivery Carriers J. Biomater. Sci. Polym. Ed. 2013, 24, 741
45. Schramm, O. G.; Pavlov, G. M.; van Erp, H. P.; Meier, M. A. R.; Hoogenboom, R.; Schubert, U. S. A Versatile Approach to Unimolecular Water-Soluble Carriers: ATRP of PEGMA with Hydrophobic Star-Shaped Polymeric Core Molecules as an Alternative for PEGylation Macromolecules 2009, 42, 1808
46. Sheiko, S. S.; Borisov, O. V.; Prokhorova, S. A.; Moller, M. Cylindrical Molecular Brushes under Poor Solvent Conditions: Microscopic Observation and Scaling Analysis Eur. Phys. J. E. Soft Matter 2004, 13, 125
47. Han, D.; Tong, X.; Zhao, Y. One-Pot Synthesis of Brush Diblock Copolymers through Simultaneous ATRP and Click Coupling Macromolecules 2011, 44, 5531
48. Bareford, L. M.; Swaan, P. W. Endocytic Mechanisms for Targeted Drug Delivery Adv. Drug Delivery Rev. 2007, 59, 748
49. Soppimath, K. S.; Liu, L. H.; Seow, W. Y.; Liu, S. Q.; Powell, R.; Chan, P.; Yang, Y. Y. Multifunctional Core/Shell Nanoparticles Self-Assembled from pH-Induced Thermosensitive Polymers for Targeted Intracellular Anticancer Drug Delivery Adv. Funct. Mater. 2007, 17, 355
50. Zhang, Y.; Yang, Y.; Hong, H.; Cai, W. Multimodality Molecular Imaging of CD105 (Endoglin) Expression Int. J. Clin. Exp. Med 2011, 4, 32
51. 18F-based Radiotracers Am. J. Nucl. Med. Mol. Imaging 2012, 2, 55
52. 11C-acetate Am. J. Nucl. Med. Mol. Imaging 2012, 2, 33
53. Fakhri, G. E. Ready for Prime Time? Dual Tracer PET and SPECT Imaging Am. J. Nucl. Med. Mol. Imaging 2012, 2, 415
54. Nolting, D. D.; Nickels, M. L.; Guo, N.; Pham, W. Molecular Imaging Probe Development: a Chemistry Perspective Am. J. Nucl. Med. Mol. Imaging 2012, 2, 273
55. van Dongen, G. A.; Ussi, A. E.; de Man, F. H.; Migliaccio, G. EATRIS, a European Initiative to Boost Translational Biomedical Research Am. J. Nucl. Med. Mol. Imaging 2013, 3, 166
56. Ravetch, J. V.; Bolland, S. IgG Fc receptors Annu. Rev. Immunol. 2001, 19, 275